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US5114932A
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Hyperosmolar oxyreplete hemosubstitute
Assignee: Individual
•
Filing: 1990-11-30
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Granted: 1992-05-19
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Expires: 2010-11-30
Abstract
Abstract New blood substitutes are described having osmolarities greater than normal blood. The new blood substitues typically comprise a physiologically acceptable fluid electrolyte solution, a physiologically acceptable agent capable of increasing the osmolarity of the blood substitute to a value greater than normal blood, an oxygen carrying substance, and a sufficient amount of water to achieve the desired osmolarity. The blood substitutes of the present invention have osmolarities in the range of 500-800 milliosmoles per liter.
Inventors
- 👤 Thomas M. Runge
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 02:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; A61K31/025; A61K31/13; A61K33/00; A61K33/42; A61K38/00; A61K38/16; A61K38/41; A61K38/42
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
17 words
A blood substitute comprising an oxygen carrier and having an osmolarity greater than 303 milliosmoles per liter.
Claim 2
Dependent Claim
17 words
A blood substitute comprising an oxygen carrier and having an osmolarity greater than 303 milliosmoles per liter.
Claim 3
Dependent Claim
17 words
The blood substitute of claim 1 having an osmolarity in the range of 500-800 milliosmoles per liter.
Claim 4
Dependent Claim
17 words
The blood substitute of claim 2 having an osmolarity in the range of 600-800 milliosmoles per liter.
Claim 5
Dependent Claim
13 words
The blood substitute of claim 1 comprising a perfluorocarbon emulsion and a disaccharide.
Claim 6
Dependent Claim
34 words
A hyperosmolar blood substitute comprising an oxygen carrier and a physiologically acceptable molecule having a molecular trait less diffusible than dextrose and wherein said substitute has an osmolarity greater than 303 milliosmoles per liter.
Claim 7
Dependent Claim
34 words
A hyperosmolar blood substitute comprising an oxygen carrier and a physiologically acceptable molecule having a molecular trait less diffusible than dextrose and wherein said substitute has an osmolarity greater than 303 milliosmoles per liter.
Claim 8
Dependent Claim
14 words
The blood substitute of claim 5, wherein the oxygen carrying agent is a perfluorocarbon.
Claim 9
Dependent Claim
16 words
The blood substitute of claim 5, wherein said molecule less diffusible than dextrose is a disaccharide.
Claim 10
Dependent Claim
11 words
The blood substitute of claim 7, wherein the disaccharide is sucrose.
Claim 11
Dependent Claim
18 words
The blood substitute of claim 5, wherein the oxygen carrying substance is a synthetic hemoglobin or recombinant hemoglobin.
Claim 12
Dependent Claim
23 words
A blood substitute comprising an oxygen carrier and a cyclodextrin and wherein said substitute has an osmolarity greater than 303 milliosmoles per liter.
Claim 13
Dependent Claim
23 words
A blood substitute comprising an oxygen carrier and a cyclodextrin and wherein said substitute has an osmolarity greater than 303 milliosmoles per liter.
Claim 14
Dependent Claim
54 words
A hyperosmolar blood substitute composition comprising: (a) a physiologically acceptable fluid electrolyte solution; (b) a physiologically acceptable agent capable of increasing the osmolarity of said blood substitute to a value greater than that of protein free blood; (c) an oxygen carrying substance; and (d) a sufficient amount of water to achieve the desired osmolarity.
Claim 15
Dependent Claim
54 words
A hyperosmolar blood substitute composition comprising: (a) a physiologically acceptable fluid electrolyte solution; (b) a physiologically acceptable agent capable of increasing the osmolarity of said blood substitute to a value greater than that of protein free blood; (c) an oxygen carrying substance; and (d) a sufficient amount of water to achieve the desired osmolarity.
Claim 16
Dependent Claim
37 words
A hyperosmolar priming solution comprising: (a) physiologically acceptable electrolytes and (b) a physiologically acceptable agent capable of increasing the osmolarity of said priming solution to a value in the range of 500 to 800 milliosmoles per liter.
Claim 17
Dependent Claim
37 words
A hyperosmolar priming solution comprising: (a) physiologically acceptable electrolytes and (b) a physiologically acceptable agent capable of increasing the osmolarity of said priming solution to a value in the range of 500 to 800 milliosmoles per liter.
Claim 18
Dependent Claim
16 words
A blood substitute comprising: (a) a hyperosmolar priming solution; and (b) an oxygen carrying synthetic substance.
Claim 19
Dependent Claim
16 words
A blood substitute comprising: (a) a hyperosmolar priming solution; and (b) an oxygen carrying synthetic substance.
Claim 20
Dependent Claim
51 words
A blood substitute having an osmolarity greater than normal human blood comprising in addition to those physiologically acceptable crystalloids present in normal blood, a physiologically acceptable oxygen carrier substance selected from the group consisting of a perfluorocarbon, a synthetic hemoglobin, a recombinant hemoglobin and mixtures thereof and a physiologically acceptable disaccharide.
Claim 21
Dependent Claim
51 words
A blood substitute having an osmolarity greater than normal human blood comprising in addition to those physiologically acceptable crystalloids present in normal blood, a physiologically acceptable oxygen carrier substance selected from the group consisting of a perfluorocarbon, a synthetic hemoglobin, a recombinant hemoglobin and mixtures thereof and a physiologically acceptable disaccharide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-19 | 1995-11-18 | 1996-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-19 | 1999-11-18 | 2000-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-19 | 2003-11-18 | 2004-05-19 | $7700.00 | Window Closed / Lapsed |