US5109844A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Retinal microstimulation
Assignee: Duke University
•
Filing: 1990-10-11
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Granted: 1992-05-05
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Expires: 2010-10-11
Abstract
Abstract A method for stimulating a retinal ganglion cell in a retina without penetrating the retinal basement membrane at the surface of the retina comprises: (a) positioning a ganglion cell stimulating electrode on or above the retinal basement membrane; (b) providing a ground electrode in operative association with the ganglion cell stimulating electrode, with the ground electrode positioned on or above the retinal basement membrane and positioned for capturing electric current produced by the stimulating electrode; and (c) applying a voltage to said stimulating electrode sufficient to produce an electric current which penetrates the retina and produces an action potential in a retinal ganglion cell. Apparatus for practicing the foregoing method is also disclosed.
Inventors
- 👤 Eugene de Juan, Jr.
- 👤 Mark S. Humayun
- 👤 D. Howard Phillips
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 03:58
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/05; A61N1/0526; A61N1/0543; A61N1/18; A61N1/32; A61N1/36; A61N1/36046; A61N1/372; A61N1/37205
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
105 words
A method for stimulating a retinal ganglion cell in a retina without penetrating the retinal basement membrane at the surface of the retina, comprising: (a) positioning a ganglion cell stimulating electrode on or above the retinal basement membrane; (b) providing a ground electrode in operative association with the ganglion cell stimulating electrode, with the ground electrode positioned on or above the retinal basement membrane and positioned for capturing electric current produced by the stimulating electrode; and (c) applying an electrical signal to said stimulating electrode sufficient to produce an electric current which penetrates the retina and produces an action potential in a retinal ganglion cell.
Claim 2
Independent Claim
105 words
A method for stimulating a retinal ganglion cell in a retina without penetrating the retinal basement membrane at the surface of the retina, comprising: (a) positioning a ganglion cell stimulating electrode on or above the retinal basement membrane; (b) providing a ground electrode in operative association with the ganglion cell stimulating electrode, with the ground electrode positioned on or above the retinal basement membrane and positioned for capturing electric current produced by the stimulating electrode; and (c) applying an electrical signal to said stimulating electrode sufficient to produce an electric current which penetrates the retina and produces an action potential in a retinal ganglion cell.
Claim 3
Dependent Claim
22 words
A method according to claim 1, wherein the stimulating electrode is located not less than about 10 microns from the ground electrode.
Claim 4
Independent Claim
123 words
A method for stimulating a plurality of retinal ganglion cells in a retina without penetrating the retinal basement membrane at the surface of the retina, comprising: (a) positioning a plurality of ganglion cell stimulating electrodes on or above the retinal basement membrane, the electrodes being laterally spaced apart from one another; (b) providing a ground electrode in operative association with each of the ganglion cell stimulating electrodes, with the ground electrode positioned on or above the retinal basement membrane and positioned for capturing electric current produced by its associated stimulating electrode; and (c) applying an electrical signal to selected ones of said stimulating electrodes sufficient to produce an electric current which penetrates the retina and produces an action potential in retinal ganglion cells.
Claim 5
Independent Claim
123 words
A method for stimulating a plurality of retinal ganglion cells in a retina without penetrating the retinal basement membrane at the surface of the retina, comprising: (a) positioning a plurality of ganglion cell stimulating electrodes on or above the retinal basement membrane, the electrodes being laterally spaced apart from one another; (b) providing a ground electrode in operative association with each of the ganglion cell stimulating electrodes, with the ground electrode positioned on or above the retinal basement membrane and positioned for capturing electric current produced by its associated stimulating electrode; and (c) applying an electrical signal to selected ones of said stimulating electrodes sufficient to produce an electric current which penetrates the retina and produces an action potential in retinal ganglion cells.
Claim 6
Dependent Claim
31 words
A method according to claim 3, wherein said plurality of electrodes are arranged in a two-dimensional array, and wherein a plurality of electrodes extend in each dimension of said two-dimensional array.
Claim 7
Dependent Claim
25 words
A method according to claim 3, wherein each of said stimulating electrodes is located not more than about 200 microns from said associated ground electrode.
Claim 8
Dependent Claim
26 words
A method according to claim 3, wherein each of said stimulating electrodes is spaced apart not more than about 200 microns from each adjacent stimulating electrode.
Claim 9
Dependent Claim
24 words
A method according to claim 3, wherein each stimulating electrode is located not less than about 10 microns from the operatively associated ground electrode.
Claim 10
Dependent Claim
159 words
A retinal microstimulator for stimulating retinal ganglion cells without penetrating the retinal basement membrane at the surface of the retina, comprising: (a) a substantially flat planar basement membrane contact portion; (b) an electrode carrier having an upper and lower surface, said basement membrane contact portion connected to said electrode carrier upper surface; (c) a plurality of stimulating electrodes having upper and lower portions, said stimulating electrode lower portions connected to said electrode carrier upper surface, and with said stimulating electrode upper portions projecting outward from said electrode carrier upper surface a distance not greater than said basement membrane contact portion; and (d) a ground electrode operatively associated with each of said stimulating electrodes; said ground electrode having an upper and lower portion, said ground electrode lower portion connected to said electrode carrier upper surface, and with said ground electrode upper portion projecting outward from said electrode carrier upper surface a distance not greater than said basement membrane contact portion.
Claim 11
Dependent Claim
159 words
A retinal microstimulator for stimulating retinal ganglion cells without penetrating the retinal basement membrane at the surface of the retina, comprising: (a) a substantially flat planar basement membrane contact portion; (b) an electrode carrier having an upper and lower surface, said basement membrane contact portion connected to said electrode carrier upper surface; (c) a plurality of stimulating electrodes having upper and lower portions, said stimulating electrode lower portions connected to said electrode carrier upper surface, and with said stimulating electrode upper portions projecting outward from said electrode carrier upper surface a distance not greater than said basement membrane contact portion; and (d) a ground electrode operatively associated with each of said stimulating electrodes; said ground electrode having an upper and lower portion, said ground electrode lower portion connected to said electrode carrier upper surface, and with said ground electrode upper portion projecting outward from said electrode carrier upper surface a distance not greater than said basement membrane contact portion.
Claim 12
Dependent Claim
26 words
An apparatus according to claim 8, wherein each of said stimulating electrodes is located not less than about 10 microns from said operatively associated ground electrode.
Claim 13
Dependent Claim
35 words
An apparatus according to claim 8, wherein said plurality of electrodes are arranged on said electrode carrier in a two-dimensional array, and wherein a plurality of electrodes extend in each dimension of said two-dimensional array.
Claim 14
Dependent Claim
21 words
An apparatus according to claim 8 comprising sixty-four stimulating electrodes arranged in eight rows, with eight stimulating electrodes in each row.
Claim 15
Dependent Claim
26 words
An apparatus according to claim 8, wherein each of said stimulating electrodes is located not more than about 200 microns from said operatively associated ground electrode.
Claim 16
Dependent Claim
26 words
An apparatus according to claim 8, wherein each of said stimulating electrodes is spaced apart not more than about 200 microns from each adjacent stimulating electrode.
Claim 17
Dependent Claim
207 words
A sensory prosthesis for a vision-impaired patient, comprising: (a) photodetector means for detecting a light signal; (b) a retinal microstimulator for stimulating retinal ganglion cells without penetrating the retinal basement membrane at the surface of the retina, comprising: (i) a substantially flat basement membrane contact portion; (ii) an electrode carrier having an upper and lower surface, said basement membrane contact portion connected to said electrode carrier upper surface; (iii) a plurality of stimulating electrodes having upper and lower portions, said stimulating electrode lower portions connected to said electrode carrier upper surface, and with said stimulating electrode upper portions projecting outward from said electrode carrier upper surface a distance not greater than said basement membrane contact portion; and (iv) a ground electrode operatively associated with each of said stimulating electrodes; said ground electrode having an upper and lower portion, said ground electrode lower portion connected to said electrode carrier upper surface, and with said ground electrode upper portion projecting outward from said electrode carrier upper surface a distance not greater than said basement membrane contact portion; and (c) means operatively associating said photodetector means with said retinal microstimulator for translating a light signal detected by said photodetector means into an electrical signal at said plurality of stimulating electrodes.
Claim 18
Dependent Claim
207 words
A sensory prosthesis for a vision-impaired patient, comprising: (a) photodetector means for detecting a light signal; (b) a retinal microstimulator for stimulating retinal ganglion cells without penetrating the retinal basement membrane at the surface of the retina, comprising: (i) a substantially flat basement membrane contact portion; (ii) an electrode carrier having an upper and lower surface, said basement membrane contact portion connected to said electrode carrier upper surface; (iii) a plurality of stimulating electrodes having upper and lower portions, said stimulating electrode lower portions connected to said electrode carrier upper surface, and with said stimulating electrode upper portions projecting outward from said electrode carrier upper surface a distance not greater than said basement membrane contact portion; and (iv) a ground electrode operatively associated with each of said stimulating electrodes; said ground electrode having an upper and lower portion, said ground electrode lower portion connected to said electrode carrier upper surface, and with said ground electrode upper portion projecting outward from said electrode carrier upper surface a distance not greater than said basement membrane contact portion; and (c) means operatively associating said photodetector means with said retinal microstimulator for translating a light signal detected by said photodetector means into an electrical signal at said plurality of stimulating electrodes.
Claim 19
Dependent Claim
35 words
A visual prosthesis according to claim 14, wherein said photodetector means, said retinal microstimulator, and said means operatively associating said photodetector means with said retinal microstimulator are together configured to be implanted within an eye.
Claim 20
Dependent Claim
27 words
A visual prosthesis according to claim 14, wherein each of said stimulating electrodes is located not less than about 10 microns from said operatively associated ground electrode.
Claim 21
Dependent Claim
36 words
A visual prosthesis according to claim 14, wherein said plurality of electrodes are arranged on said electrode carrier in a two-dimensional array, and wherein a plurality of electrodes extend in each dimension of said two-dimensional array.
Claim 22
Dependent Claim
22 words
A visual prosthesis according to claim 14 comprising sixty-four stimulating electrodes arranged in eight rows, with eight stimulating electrodes in each row.
Claim 23
Dependent Claim
27 words
A visual prosthesis according to claim 14, wherein each of said stimulating electrodes is located not more than about 200 microns from said operatively associated ground electrode.
Claim 24
Dependent Claim
27 words
A visual prosthesis according to claim 14, wherein each of said stimulating electrodes is spaced apart not more than about 200 microns from each adjacent stimulating electrode.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-05 | 1995-11-04 | 1996-05-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-05 | 1999-11-04 | 2000-05-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-05 | 2003-11-04 | 2004-05-05 | $7700.00 | Window Closed / Lapsed |