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US5103175A
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Method for a multi-dimensional measurement of magnetic resonance in defined small volume regions of a solid-state sample
Assignee: Bruker Biospin MRI GmbH
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Filing: 1990-07-03
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Granted: 1992-04-07
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Expires: 2010-07-03
Abstract
Abstract A method is disclosed for a multi-dimensional measurement of magnetic resonance in defined small volume regions of solid-state samples. The samples are arranged in a uniform homogeneous magnetic field and, in a predetermined manner, irradiated with a sequence of high frequency pulses as well as exposed to a sequence of gradient magnetic field pulses. This is done in such a way that the spin magnetization to be measured is maintained for a time interval which is longer then the amount of time needed to switch-off the gradient magnetic field pulses. Initially, in a first time interval, the magnetization of a single slice only of the sample is transferred into a transverse magnetization tilted by 90° with respect to the direction of the constant homogeneous magnetic field. Thereupon, in a second time interval, volume selective gradient magnetic field pulses are irradiated on the sample. In a subsequent third time interval, during the persistance of the volume selective gradient magnetic field pulses, high frequency pulses are irradiated on the sample, for transferring the transverse magnetization in the volume region to be measured into a multipole-state, said state being insensitive to the volume selective magnetic field pulses and persisting until after the point in time when these pulses are switched-off. Finally, in a subsequent fourth time interval, the multipole-state is transferred back again into a transverse magnetization and this magnetization is read-out as a signal.
Inventors
- 👤 Rainer Kimmich
- 👤 Eberhard Rommel
- 👤 Siegfried Hafner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 03:50
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/4816
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
224 words
A method for a two-dimensional measurement of magnetic resonance in defined small volume regions of a solid-state sample, comprising the steps of: arranging said sample in a uniform homogeneous magnetic field having a predetermined direction; irradiating said sample with a sequence of gradient magnetic field pulses in such a way that a spin magnetization to be measured is maintained for a time interval being longer than a switch-off time of said gradient magnetic field pulses; in a first time interval transferring said magnetization of only one slice of said sample into a first transverse magnetization, tilted by 90° with respect to said predetermined direction; in a second time interval, succeeding said first time interval, switching on volume selective gradient magnetic field pulses; in a third time interval, succeeding said second time interval, during persistence of said volume selective gradient magnetic field pulse, irradiating onto said sample high frequency pulses transferring said first transverse magnetization within said volume region to be measured into a multipole-state, said state being insensitive to said volume selective gradient magnetic field pulse and persisting until after a point in time when said volume selective gradient magnetic field pulses are switched-off; in a fourth time interval succeeding said third time interval, transferring said multipole-state back into a second transverse magnetization; and reading out said second transverse magnetization as a measuring signal.
Claim 2
Independent Claim
224 words
A method for a two-dimensional measurement of magnetic resonance in defined small volume regions of a solid-state sample, comprising the steps of: arranging said sample in a uniform homogeneous magnetic field having a predetermined direction; irradiating said sample with a sequence of gradient magnetic field pulses in such a way that a spin magnetization to be measured is maintained for a time interval being longer than a switch-off time of said gradient magnetic field pulses; in a first time interval transferring said magnetization of only one slice of said sample into a first transverse magnetization, tilted by 90° with respect to said predetermined direction; in a second time interval, succeeding said first time interval, switching on volume selective gradient magnetic field pulses; in a third time interval, succeeding said second time interval, during persistence of said volume selective gradient magnetic field pulse, irradiating onto said sample high frequency pulses transferring said first transverse magnetization within said volume region to be measured into a multipole-state, said state being insensitive to said volume selective gradient magnetic field pulse and persisting until after a point in time when said volume selective gradient magnetic field pulses are switched-off; in a fourth time interval succeeding said third time interval, transferring said multipole-state back into a second transverse magnetization; and reading out said second transverse magnetization as a measuring signal.
Claim 3
Dependent Claim
78 words
The method of claim 1, wherein said transverse magnetization is produced in said first time interval through a first pulse sequence consisting of a first hard high frequency pulse immediately followed by a spin-lock pulse with a phase position shifted by 90° with respect to said first 90° high frequency pulse as well as, immediately thereafter, a second 90° high frequency pulse whose phase position is shifted by 180° with respect to the first 90° high frequency pulse.
Claim 4
Dependent Claim
81 words
The method of claim 1, wherein said second pulse sequence for said transfer into and out of said multipole-state consists of a 90° high frequency pulse followed, after said third time interval, by a first 45° high frequency pulse as well as, following a further time interval, a second 45° high frequency pulse whereby, preferably, said 45° high frequency pulses have equal alternate phase positions with respect to said 90° high frequency pulse or are adjusted to be shifted by 90°.
Claim 5
Dependent Claim
16 words
The method of claim 1, wherein said gradient magnetic field pulses are step-wise encoded in amplitude.
Claim 6
Independent Claim
173 words
A method for a three-dimensional measurement of magnetic resonance in defined small volume regions of a solid-state sample, comprising the steps of: arranging said sample in a uniform homogeneous magnetic field; irradiating said sample with a sequence of gradient magnetic field pulses in such a way that a spin magnetization to be measured is maintained for a time interval being longer than a switch-off time of said gradient magnetic field pulses; in a first time interval switching on volume selective gradient magnetic field pulses; in a second time interval succeeding said first time interval, irradiating said sample during the persistence of said volume selective gradient magnetic field pulses with high frequency pulses for transferring said magnetization in said volume region to be measured into a multipole-state, said state being insensitive to said volume selective gradient magnetic field pulses and persisting until after a point in time at which said gradient magnetic field pulses are switched off; transferring said magnetization back out of said multipole-state; and reading out said magnetization as a measuring signal.
Claim 7
Independent Claim
173 words
A method for a three-dimensional measurement of magnetic resonance in defined small volume regions of a solid-state sample, comprising the steps of: arranging said sample in a uniform homogeneous magnetic field; irradiating said sample with a sequence of gradient magnetic field pulses in such a way that a spin magnetization to be measured is maintained for a time interval being longer than a switch-off time of said gradient magnetic field pulses; in a first time interval switching on volume selective gradient magnetic field pulses; in a second time interval succeeding said first time interval, irradiating said sample during the persistence of said volume selective gradient magnetic field pulses with high frequency pulses for transferring said magnetization in said volume region to be measured into a multipole-state, said state being insensitive to said volume selective gradient magnetic field pulses and persisting until after a point in time at which said gradient magnetic field pulses are switched off; transferring said magnetization back out of said multipole-state; and reading out said magnetization as a measuring signal.
Claim 8
Dependent Claim
81 words
The method of claim 5, wherein said second pulse sequence for said transfer into and out of said multipole-state consists of a 90° high frequency pulse followed, after said third time interval, by a first 45° high frequency pulse as well as, following a further time interval, a second 45° high frequency pulse whereby, preferably, said 45° high frequency pulses have equal alternate phase positions with respect to said 90° high frequency pulse or are adjusted to be shifted by 90°.
Claim 9
Dependent Claim
16 words
The method of claim 5, wherein said gradient magnetic field pulses are step-wise encoded in amplitude.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-04-07 | 1995-10-07 | 1996-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-04-07 | 1999-10-07 | 2000-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-04-07 | 2003-10-07 | 2004-04-07 | $7700.00 | Window Closed / Lapsed |