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Patent US5101158A successfully refreshed from Google Patents.
US5101158A
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Investigating a sample using NMR
Assignee: Individual
•
Filing: 1988-04-20
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Granted: 1992-03-31
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Expires: 2008-04-20
Abstract
Abstract A method of investigating a sample using nuclear magnetic resonance comprises: I) applying a magnetic field across the sample, II) applying an RF pulse to create single quantum coherences within the sample, III) applying a coherence transfer pulse after one of a first and second type of period, IV) sensing the free induction decay (FID) signa generated by the sample after the other of the first and second types of period and repeating steps II-IV with different durations (D 1 ) of the first type of period, the duration (D 2 ) of the second type of period being constant wherein during the first type of period nuclear spins of the single quantum coherence are allowed to evolve under the influence of the surrounding sample and magnetic field for the duration D 2 of the first period type, and wherein at the end of one portion of duration D 21 where D 21 =D 2 -D 1 , of the second type of period nuclear spins of the single quantum coherences have evolved only under the influence of scaler coupling with other spins while for the remainder of the second type of period nuclear spins of the single quantum coherences are allowed to evolve under the influences of the surrounding sample and magnetic field.
Inventors
- 👤 Laurence D. Hall
- 👤 Timothy J. Norwood
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 02:01
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/46; G01R33/4608
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
217 words
A method of investigating a sample using nuclear magnetic resonance the method comprising I. applying a magnetic field across the sample; II. applying a rf pulse to create single quantum coherences within the sample; III. applying a coherence transfer pulse after one of a first and second type of period; IV. sensing the free induction decay (FID) signal generated by the sample after the other of the first and second types of period; and repeating steps II-IV with different durations (D 1 ) of the first type of period, the duration (D 2 ) of the second type of period being constant wherein during the first type of period nuclear spins of the single quantum coherences are allowed to evolve under the influence of the surrounding sample and magnetic field for the duration D 1 of the first period type, and wherein at the end of one portion of duration D 21 , where D 21 =D 2 -D 1 , of the second type of period nuclear spins of the single quantum coherences have evolved only under the influence of scalar coupling with other spins while for the remainder of the second type of period nuclear spins of the single quantum coherences are allowed to evolve under the influences of the surrounding sample and magnetic field.
Claim 2
Independent Claim
217 words
A method of investigating a sample using nuclear magnetic resonance the method comprising I. applying a magnetic field across the sample; II. applying a rf pulse to create single quantum coherences within the sample; III. applying a coherence transfer pulse after one of a first and second type of period; IV. sensing the free induction decay (FID) signal generated by the sample after the other of the first and second types of period; and repeating steps II-IV with different durations (D 1 ) of the first type of period, the duration (D 2 ) of the second type of period being constant wherein during the first type of period nuclear spins of the single quantum coherences are allowed to evolve under the influence of the surrounding sample and magnetic field for the duration D 1 of the first period type, and wherein at the end of one portion of duration D 21 , where D 21 =D 2 -D 1 , of the second type of period nuclear spins of the single quantum coherences have evolved only under the influence of scalar coupling with other spins while for the remainder of the second type of period nuclear spins of the single quantum coherences are allowed to evolve under the influences of the surrounding sample and magnetic field.
Claim 3
Dependent Claim
52 words
A method according to claim 1, wherein the initial amplitude and phase of the FID signal is sensed in step IV and, after repeating steps II-IV a number of times, transforming the resultant set of amplitudes and phases expressed as a function of the first period type duration into the frequency domain.
Claim 4
Dependent Claim
13 words
A method according to claim 2, wherein the transformation comprises a Fourier transformation.
Claim 5
Dependent Claim
38 words
A method according to claim 1, wherein a 180° rf pulse is injected into the sample orthogonal to the magnetic field at the mid point of the one portion, D 21 , of the second type of period.
Claim 6
Dependent Claim
16 words
A method according to claim 1, wherein the magnetic field applied across the sample is inhomogeneous.
Claim 7
Dependent Claim
38 words
A method according to claim 1, further comprising providing before the beginning or after the end of the first type of period a scaling pulse sequence comprising a 180° rf pulse preceeded and followed by equal time intervals.
Claim 8
Dependent Claim
28 words
A method according to claim 6, wherein the time intervals before and after the 180° scaling pulse comprise multiples of the duration of the first type of period.
Claim 9
Dependent Claim
35 words
A method according to claim 1, wherein the first type of period is split into temporally separate portions by a scaling pulse sequence comprising a 180° rf pulse preceeded and followed by equal time intervals.
Claim 10
Dependent Claim
28 words
A method according to claim 8, wherein the time intervals before and after the 180° scaling pulse comprise multiples of the duration of the first type of period.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-03-31 | 1995-09-30 | 1996-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-31 | 1999-09-30 | 2000-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-31 | 2003-09-30 | 2004-03-31 | $7700.00 | Window Closed / Lapsed |