US5093531A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polyethylene glycol substituted phenyl glyoxals
Assignee: Sumitomo Pharma Co Ltd
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Filing: 1989-05-05
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Granted: 1992-03-03
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Expires: 2009-05-05
Abstract
Abstract A polyethylene glycol derivative of the formula ##STR1## wherein R represents a lower alkyl and n represents an optional positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000, a peptide modified by said polyethylene glycol derivative and a method for production thereof. The polyethylene glycol derivative (I) is capable of modifying the guanidino groups in peptides. The peptides modified by the polyethylene glycol derivative (I) are extremely stable, are considerably delayed in biological clearance (i.e. the durability is extended) and exhibit their physiological activities effectively over the long period.
Inventors
- 👤 Akihiko Sano
- 👤 Hiroo Maeda
- 👤 Yoshiyuki Kai
- 👤 Keiichi Ono
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 17:22
CPC Classifications
C; C08; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/321; C08G65/323; C07; C07K; C07K1/00; C07K1/06; C07K1/061; C07K1/064; C07K1/107; C07K1/1072; C07K1/1077; C08G65/329; C08G65/334; C08G65/3344; C08G65/3346
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
33 words
A polyethylene glycol derivative of the formula ##STR7## wherein R represents a lower alkyl and n represents a positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000-12,000.
Claim 2
Dependent Claim
33 words
A polyethylene glycol derivative of the formula ##STR7## wherein R represents a lower alkyl and n represents a positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000-12,000.
Claim 3
Dependent Claim
13 words
The polyethylene glycol derivative as claimed in claim 1 which is 4-monomethoxypolyethylene glycol-phenylglyoxal.
References Cited (Backward Citations)
US4179337A
Cited
EP0154316A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-03-03 | 1995-09-02 | 1996-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-03 | 1999-09-02 | 2000-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-03 | 2003-09-02 | 2004-03-03 | $7700.00 | Window Closed / Lapsed |