US5093133A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for percutaneous delivery of ibuprofen using hydroalcoholic gel
Assignee: Kenvue Brands LLC
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Filing: 1990-01-24
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Granted: 1992-03-03
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Expires: 2010-01-24
Abstract
Abstract An ibuprofen containing hydroalcoholic gel of pH 3.5 to 6.0 for topically treating inflammation or pain comprising an effective amount of ibuprofen; 40 to 60% alcohol, e.g. ethanol or isopropyl alcohol; 0-20% of a non-volatile solvent, e.g. propylene glycol; 2.0 to 5.0% gelling agents, e.g. 2.5% hydroxypropyl cellulose or 4.0% polyacrylic acid polymer; sufficient base, e.g. triethanolamine, to adjust the pH to between 3.5 and 6.0; and water; methods for delivering ibuprofen through the skin to treat inflammation or pain using the hydroalcoholic gel; and use of substantially pure S-ibuprofen to topically treat such inflammation or pain.
Inventors
- 👤 Stephen J. Wisniewski
- 👤 Mark Gemborys
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 18:33
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K47/00; A61K47/30; A61K47/32; A61K47/36; A61K47/38; A61K9/00; A61K9/0012; A61K9/0014; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
81 words
An ibuprofen hydroalcoholic gel composition consisting essentially of by weight of the total weight of the composition: about 1 to 15% substantially pure S-ibuprofen; 0 to 20% of propylene glycol; about 40 to 60% alcohol; about 2.0 to 5.0% of a gelling agent selected from the group consisting of hydroxy propyl cellulose and polyacylic acid polymens sufficient triethanolamine to adjust the pH to a range of from 3.5 to 6.0 which is about 0.25 to 2%; and water q.s. to 100%.
Claim 2
Dependent Claim
81 words
An ibuprofen hydroalcoholic gel composition consisting essentially of by weight of the total weight of the composition: about 1 to 15% substantially pure S-ibuprofen; 0 to 20% of propylene glycol; about 40 to 60% alcohol; about 2.0 to 5.0% of a gelling agent selected from the group consisting of hydroxy propyl cellulose and polyacylic acid polymens sufficient triethanolamine to adjust the pH to a range of from 3.5 to 6.0 which is about 0.25 to 2%; and water q.s. to 100%.
Claim 3
Dependent Claim
75 words
An ibuprofen hydroalcoholic gel composition consisting essentially of by weight of the total weight of the composition: about 1 to 15% of substantially pure S-ibuprofen; about 5% propylene glycol; about 40 to 60 % alcohol; about 2.5% of hydroxypropyl cellulose or about 4% of polyacrylic acid polymer; a sufficient amount of triethanolamine to adjust the pH to a range of from 4.7 to 5.7 which is about 0.25 to 2%; and water q.s. to 100%.
Claim 4
Dependent Claim
75 words
An ibuprofen hydroalcoholic gel composition consisting essentially of by weight of the total weight of the composition: about 1 to 15% of substantially pure S-ibuprofen; about 5% propylene glycol; about 40 to 60 % alcohol; about 2.5% of hydroxypropyl cellulose or about 4% of polyacrylic acid polymer; a sufficient amount of triethanolamine to adjust the pH to a range of from 4.7 to 5.7 which is about 0.25 to 2%; and water q.s. to 100%.
Claim 5
Independent Claim
154 words
A method for delivering the drug ibuprofen through the skin in order to treat inflammation or pain beneath the skin which comprises the steps of: incorporating an anti-inflammatory or analgesic effective amount of substantially pure S-ibuprofen into a hydroalcoholic gel; adjusting the pH of the gel to between 3.5 and 6.0; and topically administering said ibuprofen-containing gel to the skin of a patient, wherein the ibuprofen-hydroalcoholic gel administered has the following formulation in percent by weight of the total weight of the gel: about 1 to 15% of substantially pure S-ibuprofen; about 0 to 20% of a non-volatile solvent; about 40 to 60% an alcohol selected from the group consisting of ethanol and isopropyl alcohol; about 2.0 to 5.0% a gelling agent selected from the group consisting of hydroxypropyl cellulose and polyacrylic acid polymer; sufficient triethanolamine to adjust pH to 3.5 to 6, which is about 0.25 to 2% and water q.s. to 100%.
Claim 6
Independent Claim
154 words
A method for delivering the drug ibuprofen through the skin in order to treat inflammation or pain beneath the skin which comprises the steps of: incorporating an anti-inflammatory or analgesic effective amount of substantially pure S-ibuprofen into a hydroalcoholic gel; adjusting the pH of the gel to between 3.5 and 6.0; and topically administering said ibuprofen-containing gel to the skin of a patient, wherein the ibuprofen-hydroalcoholic gel administered has the following formulation in percent by weight of the total weight of the gel: about 1 to 15% of substantially pure S-ibuprofen; about 0 to 20% of a non-volatile solvent; about 40 to 60% an alcohol selected from the group consisting of ethanol and isopropyl alcohol; about 2.0 to 5.0% a gelling agent selected from the group consisting of hydroxypropyl cellulose and polyacrylic acid polymer; sufficient triethanolamine to adjust pH to 3.5 to 6, which is about 0.25 to 2% and water q.s. to 100%.
Claim 7
Independent Claim
134 words
A method for delivering the drug ibuprofen through the skin in order to treat inflammation or pain beneath the skin which comprises the steps of: incorporating an anti-inflammatory or analgesic effective amount of substantially pure S-ibuprofen into a hydroalcoholic gel; adjusting the pH of the gel to between 3.5 and 6.0; and topically administering said ibuprofen-containing gel to the skin of a patient, wherein the ibuprofen-hydroalcoholic gel administered has the following formulation in percent by weight of the total weight of the gel: about 1 to 15% of substantially pure S-ibuprofen; about 0 to 20% of a non-volatile solvent; about 40 to 60% of ethanol or isopropyl alcohol; about 2.0 to 5.0% of hydroxypropyl cellulose or polyacrylic acid polymer and sufficient triethanolamine to adjust pH to 3.5 to 6; and water q.s. to 100%.
Claim 8
Independent Claim
134 words
A method for delivering the drug ibuprofen through the skin in order to treat inflammation or pain beneath the skin which comprises the steps of: incorporating an anti-inflammatory or analgesic effective amount of substantially pure S-ibuprofen into a hydroalcoholic gel; adjusting the pH of the gel to between 3.5 and 6.0; and topically administering said ibuprofen-containing gel to the skin of a patient, wherein the ibuprofen-hydroalcoholic gel administered has the following formulation in percent by weight of the total weight of the gel: about 1 to 15% of substantially pure S-ibuprofen; about 0 to 20% of a non-volatile solvent; about 40 to 60% of ethanol or isopropyl alcohol; about 2.0 to 5.0% of hydroxypropyl cellulose or polyacrylic acid polymer and sufficient triethanolamine to adjust pH to 3.5 to 6; and water q.s. to 100%.
Claim 9
Dependent Claim
68 words
An ibuprofen hydroalcoholic gel composition consisting essentially of by weight of the total weight of the composition: about 1 to 15% of substantially pure S-ibuprofen; about 5% propylene glycol; about 40 to 60% alcohol; about 2.5% of hydroxypropyl cellulose or about 4% of polyacrylic acid polymer; a sufficient amount of triethanolamine to adjust the pH to a range of from 4.7 to 5.7; and water q.s. to 100%.
Claim 10
Dependent Claim
68 words
An ibuprofen hydroalcoholic gel composition consisting essentially of by weight of the total weight of the composition: about 1 to 15% of substantially pure S-ibuprofen; about 5% propylene glycol; about 40 to 60% alcohol; about 2.5% of hydroxypropyl cellulose or about 4% of polyacrylic acid polymer; a sufficient amount of triethanolamine to adjust the pH to a range of from 4.7 to 5.7; and water q.s. to 100%.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-03-03 | 1995-09-02 | 1996-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-03 | 1999-09-02 | 2000-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-03 | 2003-09-02 | 2004-03-03 | $7700.00 | Window Closed / Lapsed |