Apparatus and method for iontophoretic transfer

Claim 1

A transdermal iontophoretic drug delivery system for delivering an exercise simulating agent comprising: an electrode including a metallic conductive element, and a gel reservoir, the gel reservoir being disposed adjacent to the metallic conductive element, and a gel disposed in the gel reservoir including a catecholamine analog as an exercise stimulating agent, a viscosity-control agent comprising hydroxypropyl methylcellulose dispersed to form an aqueous sol with an antioxidant, a preservative, a chelator and a buffer.

Claim 12

A method for iontophoretically delivering a catecholamine amino isopropanol exercise simulating agent comprising applying to a patient's skin a first electrode comprising a reservoir containing a substance to be iontophoretically delivered, said reservoir further comprising a viscosity control agent comprising 4-10% (w/v) hydroxypropyl methylcellulose, 0.1-10% (w/v) sodium metabisulfite, 0.001-0.05% (w/v) disodium salt of EDTA, 0.005-0.05M citric acid/citrate, 0.10-0.20% (w/v) parabens which comprises a mixture of methyl and 0.02-0.04% (w/v) propyl, said method further comprising securing a second electrode to the patient a short distance from said first electrode, said second electrode comprising a gel reservoir having disposed therein 4-10% (w/v) hydroxypropyl methylcellulose, 0.1-0.5% sodium chloride, 0.10-0.20% (w/v) parabens, 0.10-0.20% (w/v) Sodium H 2 PO 4 and 80-95% (w/v) water, and applying an electrical potential across said electrodes.

Claim 13

A method for iontophoretically delivering a catecholamine amino isopropanol exercise simulating agent comprising applying to a patient's skin a first electrode comprising a reservoir containing a substance to be iontophoretically delivered, said reservoir further comprising a viscosity control agent comprising 4-10% (w/v) hydroxypropyl methylcellulose, 0.1-10% (w/v) sodium metabisulfite, 0.001-0.05% (w/v) disodium salt of EDTA, 0.005-0.05M citric acid/citrate, 0.10-0.20% (w/v) parabens which comprises a mixture of methyl and 0.02-0.04% (w/v) propyl, said method further comprising securing a second electrode to the patient a short distance from said first electrode, said second electrode comprising a gel reservoir having disposed therein 4-10% (w/v) hydroxypropyl methylcellulose, 0.1-0.5% sodium chloride, 0.10-0.20% (w/v) parabens, 0.10-0.20% (w/v) Sodium H 2 PO 4 and 80-95% (w/v) water, and applying an electrical potential across said electrodes.