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US5086039A
Expired / Lapsed
US
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Pharmaceutical compositions and use thereof in treating inflammation
Assignee: Allelix Biopharmaceuticals Inc
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Filing: 1991-03-04
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Granted: 1992-02-04
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Expires: 2011-03-04
Abstract
Abstract Inflammation in mammals is treated by administering anti-inflammatory agent complexed with corticosteroid binding globulin (CBG).
Inventors
- 👤 Geoffrey L. Hammond
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:18
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
53 words
A pharmaceutical composition useful in treating a mammal suffering from inflammation, said composition comprising human CBG, an anti-inflammatory agent which binds therewith, and a pharmaceutically acceptable carrier, wherein the said anti-inflammatory agent has an affinity constant for CBG within the range from 0.1 to 10 nanomolar at about 4° C. and physiological pH.
Claim 2
Dependent Claim
53 words
A pharmaceutical composition useful in treating a mammal suffering from inflammation, said composition comprising human CBG, an anti-inflammatory agent which binds therewith, and a pharmaceutically acceptable carrier, wherein the said anti-inflammatory agent has an affinity constant for CBG within the range from 0.1 to 10 nanomolar at about 4° C. and physiological pH.
Claim 3
Dependent Claim
13 words
The composition according to claim 1, wherein said anti-inflammatory agent is a glucocorticoid.
Claim 4
Dependent Claim
12 words
The composition according to claim 2, wherein the anti-inflammatory agent is cortisol.
Claim 5
Dependent Claim
11 words
A composition according to claim 1 which is an injectable solution.
Claim 6
Dependent Claim
13 words
A composition according to claim 1 in a form suitable for topical administration.
Claim 7
Dependent Claim
10 words
A composition according to claim 1 which is an aerosol.
Claim 8
Dependent Claim
39 words
A pharmaceutical composition useful in treating a mammal suffering from inflammation, said composition comprising a CBG, an anti-inflammatory agent which binds therewith, and a pharmaceutically acceptable carrier selected from a composition for topical application and an aerosol inhalable formulation.
Claim 9
Dependent Claim
39 words
A pharmaceutical composition useful in treating a mammal suffering from inflammation, said composition comprising a CBG, an anti-inflammatory agent which binds therewith, and a pharmaceutically acceptable carrier selected from a composition for topical application and an aerosol inhalable formulation.
Claim 10
Dependent Claim
12 words
The composition according to claim 7, wherein the CBG is human CBG.
Claim 11
Dependent Claim
13 words
The composition according to claim 7, wherein said anti-inflammatory agent is a glucocorticoid.
Claim 12
Dependent Claim
38 words
The composition according to claim 9, wherein the anti-inflammatory agent is cortisol, wherein the said anti-inflammatory agent has an affinity constant for CBG within the range from 0.1 to 10 nanomolar at about 4° C. and physiological pH.
Claim 13
Dependent Claim
13 words
The composition according to claim 7 in a form suitable for topical administration.
Claim 14
Dependent Claim
10 words
The composition according to claim 7 which is an aerosol.
Claim 15
Independent Claim
33 words
A method for treating a mammal suffering from inflammation, comprising the step of administering to said mammal a pharmaceutical composition comprising CBG, an anti-inflammatory agent which binds therewith, and a pharmaceutically acceptable carrier.
Claim 16
Independent Claim
33 words
A method for treating a mammal suffering from inflammation, comprising the step of administering to said mammal a pharmaceutical composition comprising CBG, an anti-inflammatory agent which binds therewith, and a pharmaceutically acceptable carrier.
Claim 17
Dependent Claim
13 words
The method according to claim 13, wherein said anti-inflammatory agent is a glucocorticoid.
Claim 18
Dependent Claim
12 words
The method according to claim 14, wherein said anti-inflammatory agent is cortisol.
Claim 19
Dependent Claim
39 words
The method according to claim 13, wherein said composition is administered by injection, wherein the said anti-inflammatory agent has an affinity constant for CBG within the range from 0.1 to 10 nanomolar at about 4° C. and physiological pH.
Claim 20
Dependent Claim
12 words
The method according to claim 13, wherein said composition is administered topically.
Claim 21
Dependent Claim
13 words
The method according to claim 13, wherein said composition is administered by inhalation.
Claim 22
Dependent Claim
12 words
The method according to claim 13, wherein the CBG is human CBG.
Claim 23
Dependent Claim
13 words
The method according to claim 19, wherein said anti-inflammatory agent is a glucocorticoid.
Claim 24
Dependent Claim
12 words
The method according to claim 20, wherein said anti-inflammatory agent is cortisol.
Claim 25
Dependent Claim
13 words
The method according to claim 19, wherein said composition is administered by injection.
Claim 26
Dependent Claim
12 words
The method according to claim 19, wherein said composition is administered topically.
Claim 27
Dependent Claim
13 words
The method according to claim 19, wherein said composition is administered by inhalation.
References Cited (Backward Citations)
US4997814A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-02-03 | 1995-08-05 | 1996-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-02-03 | 1999-08-05 | 2000-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-02-03 | 2003-08-05 | 2004-02-04 | $7700.00 | Window Closed / Lapsed |