Thieno-triazolo-1,4-diazepino-2-carboxylic acid amides

Abstract

Abstract The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R 1 represents hydrogen, a C 1-C 4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably C1 or Br, or by hydroxy, cyclopropyl, C 1 -C 3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine; R 2 and R 3 , each independently, represent hydrogen, a C 1 -C 4 straight-chained or branched alkyl, C 1 -C 4 hydroxyalkyl or the two groups R 2 and R 3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C 1 -C 4 alkyl, preferably a methyl group; R 4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl; n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor. The compounds of formula I are useful in the treatment of pathological conditions and diseases in which platelet activating factor is implicated.

Inventors

• 👤 Karl-Heinz Weber
• 👤 Albrecht Harreus
• 👤 Jorge Casals-Stenzel
• 👤 Gojko Muacevic
• 👤 Wolfgang Troger
• 👤 Gerhard Walther

Bibliographic Details