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US5081031A
Expired / Lapsed
US
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Synthetic polypeptide with type iv collagen activity
Assignee: University of Minnesota System
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Filing: 1989-12-14
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Granted: 1992-01-14
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Expires: 2009-12-14
Abstract
Abstract A polypeptide having the following formula is provided: leu-ala-gly-ser-cys-leu-ala-arg-phe-ser-thr-met which can bind heparin and promote cellular adhesion. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with a composition including the polypeptide are also provided.
Inventors
- 👤 Photini-Effie C. Tsilibary
- 👤 Leo T. Furcht
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 13:50
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L27/14; A61L27/22; A61L27/227; C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; C12; C12N; C12N5/00; C12N5/0068; C12N5/06; C12N5/0602; C12N5/069; A61K; A61K38/00; C12N2533/00; C12N2533/50; C12N2533/54; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/924
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
6 words
A polypeptide of the formula: leu-ala-gly-ser-cys-leu-ala-arg-phe-ser-thr-met.
Claim 2
Dependent Claim
6 words
A polypeptide of the formula: leu-ala-gly-ser-cys-leu-ala-arg-phe-ser-thr-met.
Claim 3
Dependent Claim
22 words
A prosthetic device designed for placement in vivo, comprising a surface coated with a composition comprising a polypeptide of the formula: leu-ala-gly-ser-cys-leu-ala-arg-phe-ser-thr-met.
Claim 4
Dependent Claim
22 words
A prosthetic device designed for placement in vivo, comprising a surface coated with a composition comprising a polypeptide of the formula: leu-ala-gly-ser-cys-leu-ala-arg-phe-ser-thr-met.
Claim 5
Dependent Claim
16 words
The prosthetic device of claim 2, wherein said surface constitutes a portion of a vascular graft.
Claim 6
Dependent Claim
16 words
The prosthetic device of claim 2, wherein said surface is made of a synthetic resin fiber.
Claim 7
Dependent Claim
17 words
The prosthetic device of claim 2, wherein said surface constitutes a portion of an intraocular contact lens.
Claim 8
Dependent Claim
17 words
The prosthetic device of claim 2, wherein said surface constitutes a portion of a hip replacement implant.
Claim 9
Dependent Claim
16 words
The prosthetic device of claim 2, wherein said surface constitutes a portion of a percutaneous device.
Claim 10
Dependent Claim
23 words
A prosthetic device in accordance with claim 4, wherein said synthetic resin fiber is selected from the group consisting of nitrocellulose or polyester.
Claim 11
Dependent Claim
17 words
A prosthetic device in accordance with claim 4, wherein said synthetic resin fiber is a polyethylene terephthalate.
Claim 12
Dependent Claim
18 words
A cell culture substrate having a surface coated with a composition comprising a polypeptide of the formula: leu-ala-gly-ser-cys-leu-ala-arg-phe-ser-thr-met.
Claim 13
Dependent Claim
18 words
A cell culture substrate having a surface coated with a composition comprising a polypeptide of the formula: leu-ala-gly-ser-cys-leu-ala-arg-phe-ser-thr-met.
Claim 14
Dependent Claim
16 words
The cell culture substrate of claim 10, wherein said surface is made of a synthetic resin.
Claim 15
Dependent Claim
16 words
The cell culture substrate of claim 10, wherein said surface constitutes a portion of a bead.
Claim 16
Dependent Claim
17 words
The cell culture substrate of claim 10, wherein said surface constitutes a portion of a microporous fiber.
Claim 17
Dependent Claim
17 words
The cell culture substrate of claim 10, wherein said surface constitutes the wells of a microtiter plate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-13 | 1995-07-15 | 1996-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-13 | 1999-07-15 | 2000-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-13 | 2003-07-15 | 2004-01-14 | $7700.00 | Window Closed / Lapsed |