US5080670A
Expired / Lapsed
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Bioprosthetic valve
Assignee: Koken Co Ltd
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Filing: 1988-08-30
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Granted: 1992-01-14
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Expires: 2008-08-30
Abstract
Abstract A bioprosthetic valve made from a biological tissue containing collagen which has been cross-linked with a polyepoxy compound is disclosed. The valve has excellent biocompatibility and is durable and is free from calcification.
Inventors
- 👤 Eisaburo Imamura
- 👤 Yasuharu Noishiki
- 👤 Hitoshi Koyanagi
- 👤 Teruo Miyata
- 👤 Masayasu Furuse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 21:59
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2412; A61K; A61K35/00; A61K35/12; A61K35/34; A61L2/00; A61L2/16; A61L2/18; A61L27/3604; A61L27/3625; A61L27/50; A61L27/507; A61L2103/00; A61L2103/05; A61L2400/00; A61L2400/02; Y; Y10; Y10S; Y10S623/00; Y10S623/915
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
49 words
A bioprosthetic valve consisting essentially of an animal valve containing a crosslinked collagen/polyepoxy compound consisting of collagen crosslinked with a polyepoxy compound to an extend of 10 to 60% with respect to an ε-amino group for increasing resistance to calcification when said bioprosthetic valve is implanted in a mammal.
Claim 2
Dependent Claim
49 words
A bioprosthetic valve consisting essentially of an animal valve containing a crosslinked collagen/polyepoxy compound consisting of collagen crosslinked with a polyepoxy compound to an extend of 10 to 60% with respect to an ε-amino group for increasing resistance to calcification when said bioprosthetic valve is implanted in a mammal.
Claim 3
Dependent Claim
16 words
A bioprosthetic valve according to claim 1, wherein the polyepoxy compound is a hydrophilic polyepoxy compound.
Claim 4
Dependent Claim
42 words
A bioprosthetic valve according to claim 1, wherein the polyepoxy compound is at least one of a polyglycidyl ether having a polymerization degree of from 1 to 3 and a polyglycidyl ether of a polyol selected from dihydric, trihydric and tetrahydric alcohols.
Claim 5
Dependent Claim
42 words
A bioprosthetic valve according to claim 2, wherein the polyepoxy compound is at least one of a polyglycidyl ether having a polymerization degree of from 1 to 3 and a polyglycidyl ether of a polyol selected from dihydric, trihydric and tetrahydric alcohols.
Claim 6
Dependent Claim
37 words
A bioprosthetic valve according to claim 1, wherein the valve of the animal is selected from the group consisting of porcine aortic valve, ovine aortic valve, bovine aortic valve, mitral valve, tricuspid valve and vena caval valve.
Claim 7
Dependent Claim
22 words
A bioprosthetic valve according to claim 1, wherein said valve has a valve cusp which has been formed of a membrane-like tissue.
Claim 8
Dependent Claim
24 words
A bioprosthetic valve according to claim 6, wherein the membrane-like tissue is selected from the group consisting of pericardium, dura mater, amnion of fascia.
Claim 9
Dependent Claim
58 words
A bioprosthetic valve comprising a biological tissue prepared by a method consisting of immersing an animal valve in a solution of a polyepoxy compound and crosslinking collagen in said animal valve to an extent of 10 to 60% with respect to an ε-amino group for increasing resistance to calcification when said bioprosthetic valve is implanted in a mammal.
Claim 10
Dependent Claim
58 words
A bioprosthetic valve comprising a biological tissue prepared by a method consisting of immersing an animal valve in a solution of a polyepoxy compound and crosslinking collagen in said animal valve to an extent of 10 to 60% with respect to an ε-amino group for increasing resistance to calcification when said bioprosthetic valve is implanted in a mammal.
Claim 11
Dependent Claim
16 words
A bioprosthetic valve according to claim 8, wherein the polyepoxy compound is a hydrophilic polyepoxy compound.
Claim 12
Dependent Claim
41 words
A bioprosthetic valve according to claim 8, wherein the polyepoxy compound is at least one of a polyglycidyl ether having a polymerization degree of from 1 to 3 and a polyglycidyl ether of polyol selected from dihydric, trihydric and tetrahydric alcohols.
Claim 13
Dependent Claim
42 words
A bioprosthetic valve according to claim 9, wherein the polyepoxy compound is at least one of a polyglycidyl ether having a polymerization degree of from 1 to 3 and a polyglycidyl ether of a polyol selected from dihydric, trihydric and tetrahydric alcohols.
Claim 14
Dependent Claim
37 words
A bioprosthetic valve according to claim 8, wherein the valve of the animal is selected from the group consisting of porcine aortic valve, ovine aortic valve, bovine aortic valve, mitral valve, tricuspid valve and vena caval valve.
Claim 15
Dependent Claim
22 words
A bioprosthetic valve according to claim 8, wherein said valve has a valve cusp which has been formed of a membrane-like tissue.
Claim 16
Dependent Claim
24 words
A bioprosthetic valve according to claim 13, wherein the membrane-like tissue is selected from the group consisting of pericardium, dura mater, amnion and fascia.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-13 | 1995-07-15 | 1996-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-13 | 1999-07-15 | 2000-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-13 | 2003-07-15 | 2004-01-14 | $7700.00 | Window Closed / Lapsed |