US5080647A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition for preventing clouding of posterior capsule after extracapsular cataract eye surgery and method of performing cataract surgery
Assignee: Individual
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Filing: 1990-02-23
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Granted: 1992-01-14
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Expires: 2010-02-23
Abstract
Abstract The present invention relates to compositions for killing undifferentiated epithelial cells during cataract surgery on an eye to prevent posterior capsule clouding after the surgery and to a method for performing cataract surgery on an eye including injecting a cell-killing substance between the anterior capsule and the natural lens prior to removing the natural lens from the eye. The cell-killing substance is preferably an acid or base adjusted aqueous solution having a pH in the range between about 1.0 to below 6.5 or about above 7.5 to 14.0; or a hypotonic solution having a salinity less than 0.9% or a pH adjusted hypotonic solution having a salinity less than 0.9% and a pH either below 6.5 or above 7.5. The compositions of the present invention also incorporates a viscoelastic material, a dye or a mixture thereof, in combination with the cell-killing substance.
Inventors
- 👤 Seymour Dubroff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 23:22
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/71; A61M1/77; A61M2210/00; A61M2210/06; A61M2210/0612
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
59 words
A method of performing cataract surgery on an eye to prevent capsule clouding after the surgery comprising the step of injecting a solution comprising a cell-killing substance between the capsule and the natural lens, the substance having a pH ranging from below 6.5 to 1.0 or from above 7.5 to 14.0 and having properties to kill undifferentiated epithelial cells.
Claim 2
Independent Claim
59 words
A method of performing cataract surgery on an eye to prevent capsule clouding after the surgery comprising the step of injecting a solution comprising a cell-killing substance between the capsule and the natural lens, the substance having a pH ranging from below 6.5 to 1.0 or from above 7.5 to 14.0 and having properties to kill undifferentiated epithelial cells.
Claim 3
Dependent Claim
37 words
The method of performing cataract surgery as recited in claim 1 wherein the cell-killing substance comprises a combination of water and an acid or a combination of water and a base whereby the epithelial cells are killed.
Claim 4
Dependent Claim
46 words
The method of performing cataract surgery as recited in claim 1 wherein said injecting step includes forcing the substance between the capsule and the natural lens under pressure and further comprising the step of aspirating from the eye any of the substance escaping from the capsule.
Claim 5
Dependent Claim
36 words
The method of performing cataract surgery as recited in claim 1 wherein the substance comprises a solution of water and a base, said solution having a pH in a range from approximately 8.0 to about 8.4.
Claim 6
Dependent Claim
35 words
The method of performing cataract surgery as recited in claim 1 wherein the substance comprises a solution of water and an acid, said solution having a pH in a range between approximately 5.8 to 6.2.
Claim 7
Dependent Claim
29 words
The method as recited in claim 1 additionally comprising the step of mixing a viscoelastic material with said cell-killing substance to form said solution prior to injecting said solution.
Claim 8
Dependent Claim
18 words
The method as recited in claim 6 additionally comprising the step of mixing a dye with said solution
Claim 9
Dependent Claim
18 words
The method as recited in claim 1 additionally comprising the step of mixing a dye with said solution.
Claim 10
Dependent Claim
49 words
The method of performing cataract surgery as recited in claim 7 and further comprising the step of, prior to said injecting step, placing a viscoelastic material in the anterior chamber of the eye whereby any of the substance escaping from the capsule is prevented from reaching the corneal endothelium.
Claim 11
Dependent Claim
49 words
The method of performing cataract surgery as recited in claim 1 and further comprising the step of, prior to said injecting step, placing a viscoelastic material in the anterior chamber of the eye whereby any of the substance escaping from the capsule is prevented from reaching the corneal endothelium.
Claim 12
Independent Claim
51 words
A method of performing cataract surgery on the eye to prevent capsule clouding after the surgery comprising the step of injecting a solution comprising a mixture of a cell-killing substance and a viscoelastic material between the capsule and the natural lens, said cell-killing substance having properties to kill undifferentiated epithelial cells.
Claim 13
Independent Claim
51 words
A method of performing cataract surgery on the eye to prevent capsule clouding after the surgery comprising the step of injecting a solution comprising a mixture of a cell-killing substance and a viscoelastic material between the capsule and the natural lens, said cell-killing substance having properties to kill undifferentiated epithelial cells.
Claim 14
Dependent Claim
18 words
The method as recited in claim 11 additionally comprising the step of mixing a dye with said solution.
Claim 15
Independent Claim
40 words
A method of performing cataract surgery on the eye to prevent capsule clouding after the surgery comprising injecting a cell-killing substance and a dye between the capsule and the natural lens, the substance having properties to kill undifferentiated epithelial cells.
Claim 16
Independent Claim
40 words
A method of performing cataract surgery on the eye to prevent capsule clouding after the surgery comprising injecting a cell-killing substance and a dye between the capsule and the natural lens, the substance having properties to kill undifferentiated epithelial cells.
Claim 17
Independent Claim
53 words
A method of performing cataract surgery on the eye to prevent capsule clouding after the surgery comprising the steps of injecting a solution comprising a cell-killing substance in an amount of less than 2.0 cc between the anterior capsule and the natural lens, said cell-killing substance having properties to kill undifferentiated epithelial cells.
Claim 18
Independent Claim
53 words
A method of performing cataract surgery on the eye to prevent capsule clouding after the surgery comprising the steps of injecting a solution comprising a cell-killing substance in an amount of less than 2.0 cc between the anterior capsule and the natural lens, said cell-killing substance having properties to kill undifferentiated epithelial cells.
Claim 19
Independent Claim
41 words
A method of performing cataract surgery on an eye to prevent capsule clouding after the surgery comprising the steps of injecting a hypotonic solution between an anterior capsule and a natural lens, said solution having properties to kill undifferentiated epithelial cells.
Claim 20
Independent Claim
41 words
A method of performing cataract surgery on an eye to prevent capsule clouding after the surgery comprising the steps of injecting a hypotonic solution between an anterior capsule and a natural lens, said solution having properties to kill undifferentiated epithelial cells.
Claim 21
Dependent Claim
17 words
The method of claim 15 additionally comprising the step of mixing a dye with said hypotonic solution.
Claim 22
Dependent Claim
18 words
The method of claim 15 additionally comprising the step of mixing a viscoelastic material with said hypotonic solution.
Claim 23
Dependent Claim
41 words
The method of claim 15 additionally comprising the step of adjusting the pH of the hypotonic solution to a pH in the range from 1.0 to less than 6.5 or a pH in a range from greater than 7.5 to 14.0.
Claim 24
Dependent Claim
17 words
The method of claim 18 additionally comprising the step of mixing a dye with said hypotonic solution.
Claim 25
Dependent Claim
18 words
The method of claim 18 additionally comprising the step of mixing a viscoelastic material with said hypotonic solution.
Claim 26
Dependent Claim
33 words
The method of claim 15 additionally comprising the step of adjusting the pH of the hypotonic solution to a pH in the range from between 5.8 to 6.2 or between 8.0 to 8.4.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-13 | 1995-07-15 | 1996-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-13 | 1999-07-15 | 2000-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-13 | 2003-07-15 | 2004-01-14 | $7700.00 | Window Closed / Lapsed |