US5071646A
Expired / Lapsed
US
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Pharmaceutical ion exchange resin composition
Assignee: Euro Celtique SA
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Filing: 1989-11-09
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Granted: 1991-12-10
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Expires: 2009-11-09
Abstract
Abstract An ion exchange resin composition which is readily dispersible in water is provided. This resin composition comprises a granulated ion exchange resin, a pharmacologically active ingredient bound thereto with a sugar or sugar alcohol, and a sufficient amount of water, alcohol or aqueous alcohol to facilitate granulation. The invention further comprises a method for the preparation of such ion exchange resin composition.
Inventors
- 👤 Sandra T. A. Malkowska
- 👤 Ian R. Buxton
- 👤 Derek A. Prater
- 👤 Alison A. Norman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 10:03
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/585; A61K9/1617; A61K9/1623
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
64 words
Method of producing a pharmaceutical ion exchange resin composition that is readily dispersible in water, said method comprising granulating a pharmaceutically compatible ion exchange resin, having a pharmacologically active ingredient bound thereto, with a sugar or sugar alcohol in an amount of 25-99% by weight of the composition in the presence of a sufficient amount of water, alcohol or aqueous alcohol to facilitate granulation.
Claim 2
Dependent Claim
64 words
Method of producing a pharmaceutical ion exchange resin composition that is readily dispersible in water, said method comprising granulating a pharmaceutically compatible ion exchange resin, having a pharmacologically active ingredient bound thereto, with a sugar or sugar alcohol in an amount of 25-99% by weight of the composition in the presence of a sufficient amount of water, alcohol or aqueous alcohol to facilitate granulation.
Claim 3
Dependent Claim
21 words
Method according to claim 1 wherein said sugar of sugar alcohol is sucrose, dextrose, maltose, fructose, lactose, mannitol, sorbitol of xylitol.
Claim 4
Dependent Claim
13 words
Method according to claim 1 wherein said sugar of sugar alcohol is xylitol.
Claim 5
Dependent Claim
20 words
Method according to claim 1 wherein said sugar of sugar alcohol has a particle size of 600 microns or less.
Claim 6
Dependent Claim
26 words
Method according to claim 1 wherein at least 90% by weight of said sugar of sugar alcohol has a particle size of 250 microns or less.
Claim 7
Dependent Claim
18 words
Method according to claim 1 wherein the amount of sugar or sugar alcohol is between 70-95% by weight.
Claim 8
Dependent Claim
39 words
Method according to claim 1 the amount of water, alcohol or aqueous alcohol utilized is in an amount of 1-20% by weight of the combined weight of said pharmacologically active agent, said resin and said sugar or sugar alcohol.
Claim 9
Dependent Claim
29 words
Method according to claim 1 wherein the granulation is continued until the particle size of the ion exchange resin matches the particle size of the sugar or sugar alcohol.
Claim 10
Dependent Claim
22 words
Method according to claim 1 wherein after granulation the granules are dried until the water content thereof is below 3% by weight.
Claim 11
Dependent Claim
39 words
Method according to claim 1, wherein the amount of water, aqueous alcohol or alcohol utilized is in an amount of 2%-7% by weight of the combined weight of the pharmacologically active ingredient, resin and the sugar or sugar alcohol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-09 | 1995-06-10 | 1995-12-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-09 | 1999-06-10 | 1999-12-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-09 | 2003-06-10 | 2003-12-10 | $7700.00 | Window Closed / Lapsed |