US4369175A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the manufacture of prolonged action vincamine preparations, the vincamine preparations so obtained, and medicaments containing them
Assignee: Novartis Corp
•
Filing: 1981-07-27
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Granted: 1983-01-18
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Expires: 2001-07-27
Abstract
Abstract The invention relates to a process for the manufacture of prolonged action and stable vincamine preparations, which process comprises reacting an acid addition salt of vincamine with an alkali metal salt or alkaline earth metal salt of a sulfonic acid cation exchange resin, in particular an alkali metal salt of a sulfonated copolymer of styrene with a small amount of divinyl benzene, in a polar reaction medium such as water. The invention further relates to the vincamine preparations so obtained, to the use thereof for the manufacture of ready-for-use medicaments for oral administration and to these medicaments themselves.
Inventors
- 👤 Satish C. Khanna
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 23:16
CPC Classifications
C; C07; C07D; C07D461/00; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/585
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
44 words
A process for the manufacture of prolonged action and stable vincamine resinates, which process comprises reacting an acid addition salt of vincamine with an alkali metal salt or alkaline earth metal salt of a sulfonic acid cation exchange resin, in a polar reaction medium.
Claim 2
Dependent Claim
44 words
A process for the manufacture of prolonged action and stable vincamine resinates, which process comprises reacting an acid addition salt of vincamine with an alkali metal salt or alkaline earth metal salt of a sulfonic acid cation exchange resin, in a polar reaction medium.
Claim 3
Dependent Claim
37 words
A process according to claim 1, which comprises the use of an alkali metal salt or alkaline earth metal salt of a sulfonic acid cation exchange resin having a particle size of about 50 to 1000 μm.
Claim 4
Dependent Claim
39 words
A process according to claim 1, wherein an acid addition salt of vincamine is reacted with an alkali metal salt of a sulfonation product of a copolymer of (unsubstituted or substituted) styrene with a small amount of divinyl benzene.
Claim 5
Dependent Claim
32 words
A process according to claim 1, wherein the reaction is carried out in water, a lower alkanol, a lower alkanone or a mixture of these solvents with each other and/or with water.
Claim 6
Dependent Claim
26 words
A process according to claim 1, wherein the acid addition salt of vincamine is a mineral acid salt or a salt with an organic sulfonic acid.
Claim 7
Dependent Claim
19 words
A process according to claim 1, wherein the acid addition salt of vincamine is vincamine methanesulfonate or vincamine hydrochloride.
Claim 8
Dependent Claim
59 words
A prolonged action and stable vincamine preparation consisting of vincamine resinate which is bound with a saturation of 10 to 40% on a sulfonic acid cation exchange resin as prepared by the process of claim 1, the remaining sulfonic acid anions of which are substantially saturated by alkali metal or alkaline earth metal ions and an inert pharmaceutical carrier.
Claim 9
Dependent Claim
29 words
A vincamine preparation according to claim 7, in which vincamine is bound on a sulfonic acid cation exchange resin having a particle size of about 50 to 1000 μm.
Claim 10
Dependent Claim
31 words
A vincamine preparation according to claim 7, in which vincamine is bound on a sulfonation product of a copolymer of unsubstituted or substituted styrene with a small amount of divinyl benzene.
Claim 11
Dependent Claim
8 words
A vincamine resinate obtained according to claim 1.
Claim 12
Dependent Claim
10 words
A vincamine resinate obtained according to claims 1 or 2.
Claim 13
Dependent Claim
16 words
A vincamine resinate obtained according to any one of claims 1, 2, 3, 4 or 5.
References Cited (Backward Citations)
DE1045599B
Cited
US2990332A
Cited
GB942873A
Cited
GB892083A
Cited
GB925890A
Cited
US3313686A
Cited
GB994918A
Cited
GB1045838A
Cited
GB1191372A
Cited
FR2179538B1
Cited
FR2201898B1
Cited
FR2253507B1
Cited
FR2313915B1
Cited
DE2707763A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-17 | 1986-07-19 | 1987-01-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-17 | 1990-07-19 | 1991-01-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-17 | 1994-07-19 | 1995-01-18 | $7700.00 | Window Closed / Lapsed |