Pharmaceutical preparations comprising cation exchange resin adsorption compounds and treatment therewith

Claim 1

A PHARMACEUTICAL PREPARATION FOR ORAL ADMINISTRATION TO A PATIENT, COMPRISING IN DOSAGE UNIT FORM A THERAPEUTICALLY EFFECTIVE AMOUNT OF CROSS LINKED SULPHONIC ACID CATION EXCHANGE RESIN HAVING A GASTRO-INTESTINAL ABSORBABLE PHARMACEUTICAL ORGANIC DRUG CONTAINING A BASIC NITROGEN GROUP IONICALLY BOUND TO THE RESIN TO FORM AN ADSORPTION COMPOUND, THE CROSS LINKAGE OF THE RESIN OF THE ADSORPTION COMPOUND BEING BETWEEN APPROXIMATELY ONE TO TWENTY PERCENT AND THE PARTICLE SIZE OF THE ADSORPTION COMPOUND BEING BETWEEN APPROXIMATELY 10 MESH AND 400 MESH, AND THE CROSS LINKAGE AND PARTICLE SIZE BEING SUCH THAT NOT MORE THAN APPROXIMATELY 50 PERCENT OF THE BOUND DRUG IS RELEASED IN ONE HOUR BY ELUTION WITH .07 N HC1 AND .03 N NAC1 AND AT LEAST APPROXIMATELY 10 PERCENT IS RELEASED IN THREE HOURS, THE AMOUNT OF BOUND DRUG IN THE DOSAGE UNIT BEING BETWEEN .2 TO 2000 MILLIGRAMS CALCULATED AS DRUG BASE AND BEING IN SUFFICIENT AMOUNT AS TO BE SAFELY EFFECTIVE FOR A PERIOD OF AT LEAST EIGHT HOURS AND THE SAID DRUG IN BASE FORM HAVING AN ORAL LD-50 IN RATS OF BETWEEN APROXIMATELY 50 TO 3000 MILLIGRAMS PER KILOGRAM.