US5069904A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of using nicotine in the treatment of conditions susceptible to said treatment
Assignee: Aveva Drug Deliverty Systems Inc
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Filing: 1990-01-05
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Granted: 1991-12-03
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Expires: 2010-01-05
Abstract
Abstract Nicotine is proposed for use in the treatment of various conditions susceptible to alleviation by nicotine therapy such as disease states characterised by reduced central cholinergic function. Nicotine is administered to a subject initially having a blood supply substantially free of nicotine at a dose and for a period sufficient to allow the subject to tolerate the dose and thereafter increasing the dose of nicotine at intervals until a therapeutic dose is achieved. Smokers may also benefit from the treatment regimen.
Inventors
- 👤 Joseph G. Masterson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 10:38
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/465; A61P; A61P1/00; A61P17/00; A61P25/00; A61P25/02; A61P25/28; A61P43/00
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
90 words
A method of treating a condition susceptible to nicotine therapy which comprises administering a medicament containing nicotine to a subject in need of such treatment, wherein said medicament is administered to a subject initially having a blood supply substantially free of nicotine at a sub-therapeutic dose in the range of 1-5 mg/day and for a period of time sufficient to allow said subject to tolerate said dose without showing any adverse effects and thereafter increasing the dose of nicotine at selected intervals of time until a therapeutic dose is achieved.
Claim 2
Independent Claim
90 words
A method of treating a condition susceptible to nicotine therapy which comprises administering a medicament containing nicotine to a subject in need of such treatment, wherein said medicament is administered to a subject initially having a blood supply substantially free of nicotine at a sub-therapeutic dose in the range of 1-5 mg/day and for a period of time sufficient to allow said subject to tolerate said dose without showing any adverse effects and thereafter increasing the dose of nicotine at selected intervals of time until a therapeutic dose is achieved.
Claim 3
Dependent Claim
40 words
The method according to claim 1, wherein when said tolerance state is reached following the period of administration of said initial dose, the dose administered is increased by amounts of at least 1-5 mg/day until said therapeutic dose is achieved.
Claim 4
Dependent Claim
24 words
The method according to claim 1, wherein said condition susceptible to nicotine therapy is a disease state susceptible to relief by administration of nicotine.
Claim 5
Dependent Claim
17 words
The method according to claim 3, wherein the disease state is characterized by reduced central cholinergic function.
Claim 6
Dependent Claim
18 words
The method according to claim 4, wherein the disease state is characterized by a loss of cholinergic neurons.
Claim 7
Dependent Claim
20 words
The method according to claim 3, wherein the disease state is characterized by a significant reduction in nicotine receptor binding.
Claim 8
Dependent Claim
15 words
The method according to claim 6, wherein the disease state is characterized by neurodegenerative dementia.
Claim 9
Dependent Claim
17 words
The method according to claim 3, wherein the disease state is characterized by cognition and memory impairment.
Claim 10
Dependent Claim
12 words
The method according to claim 8, wherein the disease is Alzheimer's disease.
Claim 11
Dependent Claim
12 words
The method according to claim 3, wherein the disease is ulcerative colitis.
Claim 12
Dependent Claim
14 words
The method according to claim 1, wherein the nicotine is formulated for oral administration.
Claim 13
Dependent Claim
17 words
The method according to claim 11, wherein the nicotine is in the form of tablets or capsules.
Claim 14
Dependent Claim
14 words
The method according to claim 11, wherein the nicotine is contained in a gum.
Claim 15
Dependent Claim
14 words
The method according to claim 1, wherein the nicotine is formulated for percutaneous administration.
Claim 16
Dependent Claim
39 words
The method according to claim 14, wherein the nicotine is administered in the form of a preparation which comprises nicotine uniformly distributed in a solid, semi-solid or mucilaginous medium which can be placed in intimate contact with the skin.
Claim 17
Dependent Claim
32 words
The method according to claim 15, wherein the preparation is in the form of a solid or semi-solid and has a surface area in the range 2 to 15 cm 2 .
Claim 18
Dependent Claim
22 words
The method according to claim 16, wherein the preparation has a surface area in the range 5 to 10 cm 2 .
Claim 19
Dependent Claim
19 words
The method according to claim 15, wherein the preparation has a thickness in the range 0.5 to 3 mm.
Claim 20
Dependent Claim
19 words
The method according to claim 18, wherein the preparation has a thickness in the range 1 to 2 mm.
Claim 21
Dependent Claim
22 words
The method according to claim 15, wherein the preparation is in the form of a cream, gel, jelly, mucilage, ointment or paste.
Claim 22
Dependent Claim
94 words
The method according to claim 15, wherein the solid, semi-solid or mucilaginous medium is formed by adding a given amount of nicotine to a solution of a solidifying or gel-forming agent or mixture thereof in a suitable solvent or mixture of solvents, and mixing or treating the mixture thereby obtained so as to form said solid, semi-solid or mucilaginous medium, the solidifying or gel-forming agent being selected from the group consisting of plant extracts, vegetable oils, gums, synthetic or natural polysaccharides, polypeptides, alginates, hydrocarbons, synthetic polymers, minerals and silicon compounds or a mixture thereof.
Claim 23
Dependent Claim
45 words
The method according to claim 21, wherein the solidifying or gel-forming agent is a synthetic or natural polysaccharide selected from the group consisting of alkylcelluloses, hydroxyalkylcelluloses, cellulose ethers, cellulose esters, nitrocelluloses, dextrin, agar, carrageenan, pectin, furcellaran and starch or starch derivatives or a mixture thereof.
Claim 24
Dependent Claim
23 words
The method according to claim 15, wherein the preparation contains from 1 to 100 mg of nicotine depending on the stage of treatment.
Claim 25
Dependent Claim
49 words
The method according to claim 15, wherein the preparation contains one or more additives selected from the group consisting of an antimicrobial agent, a preservative, an antioxidant, a pH-controlling agent, a plasticizer, a surfactant, a penetration enhancer, a humectant, a local anaesthetic and a rubefacient or a mixture thereof.
Claim 26
Dependent Claim
29 words
The method according to claim 15, wherein the preparation is adapted to be received in a receptacle of a device which can be held in contact with the skin.
Claim 27
Dependent Claim
20 words
The method according to claim 15, wherein the preparation is incorporated in a self-adhesive patch, a bandage or a plaster.
Claim 28
Dependent Claim
15 words
The method according to claim 1, wherein the nicotine is administered on a once-daily basis.
Claim 29
Dependent Claim
39 words
The method according to claim 27, wherein the nicotine is administered in the form of a preparation which comprises nicotine uniformly distributed in a solid, semi-solid or mucilaginous medium which can be placed in intimate contact with the skin.
Claim 30
Independent Claim
77 words
A method of using nicotine for the treatment of a condition susceptible to nicotine therapy which comprises administering a medicament containing nicotine to a subject in need of such treatment, wherein said medicament is administered to said subject at a dose and for a period sufficient to allow said subject to tolerate said dose without showing any adverse effects and thereafter increasing the dose of nicotine at selected intervals of time until a therapeutic dose is achieved.
Claim 31
Independent Claim
77 words
A method of using nicotine for the treatment of a condition susceptible to nicotine therapy which comprises administering a medicament containing nicotine to a subject in need of such treatment, wherein said medicament is administered to said subject at a dose and for a period sufficient to allow said subject to tolerate said dose without showing any adverse effects and thereafter increasing the dose of nicotine at selected intervals of time until a therapeutic dose is achieved.
Claim 32
Independent Claim
91 words
A method of treating a condition susceptible to nicotine therapy which comprises administering percutaneously a medicament containing nicotine to a subject in need of such treatment, wherein said medicament is administered to a subject initially having a blood supply substantially free of nicotine at a sub-therapeutic dose in the range of 1-5 mg/day and for a period of time sufficient to allow said subject to tolerate said dose without showing any adverse effects and thereafter increasing the dose of nicotine at selected intervals of time until a therapeutic dose is achieved.
Claim 33
Independent Claim
91 words
A method of treating a condition susceptible to nicotine therapy which comprises administering percutaneously a medicament containing nicotine to a subject in need of such treatment, wherein said medicament is administered to a subject initially having a blood supply substantially free of nicotine at a sub-therapeutic dose in the range of 1-5 mg/day and for a period of time sufficient to allow said subject to tolerate said dose without showing any adverse effects and thereafter increasing the dose of nicotine at selected intervals of time until a therapeutic dose is achieved.
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