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US5068225A Expired / Lapsed US ⏱️ 0.0 years remaining

Viscoelastic fluid for use in surgery and other therapies and method of using same

Assignee: FzioMed Inc
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Filing: 1990-08-10
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Granted: 1991-11-26
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Expires: 2010-08-10
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Abstract

Abstract This invention relates to an improved viscoelastic fluid or gel for use in surgery and other therapies which consists of polyethylene oxide in selected concentrations not to exceed approximately 15% (15,000 ppm), contained in a physiologic balanced salt solution. The PEO may also be used in conjunction with viscosity enhancers which also act as heat stabilizers such as methylcellulose and its derivatives, polyvinyl pyrrolidone of polyvinyl alcohol or in conjunction with elasticizes such as low molecular weight polyethylene glycols or polypropylene glycols or in conjunction with gelation modifiers. These mixtures may be modified to increase retention time in the body by crosslinking with the use of material like dimethyl urea. The invention encompasses the novel method of protecting and lubricating the corneal tissues during surgery with uses of different concentrations of the same solution introduced simultaneously to protect the inner cornea while periodically irrigating the outer cornea, all without obscuring the surgeon's view of the site. This invention also prevents the development of wound adhesion and has many utilizations in orthopedics.

Inventors

  • 👤 Phillip E. Pennell
  • 👤 John M. Blackmore
  • 👤 Mark D. Allen

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 17:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048; A61F; A61F9/00; A61F9/007; A61L; A61L27/00; A61L27/14; A61L27/26; A61L2430/00; A61L2430/16

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 74 words
A method of protecting the intraocular surfaces of an eye of a mammal during ophthalmic surgery including the steps of: introducing into the eye as an aqueous/vitreous substitute, in order to protect internal eye tissues, a viscoelastic composition which comprises a solution of a cellulose derivative and polyethylene oxide (PEO in a physiologically compatible liquid, the composition being physiologically compatible with the intraocular surfaces of eye of the mammal; and performing the ophthalmic surgery.
Claim 2
Independent Claim 74 words
A method of protecting the intraocular surfaces of an eye of a mammal during ophthalmic surgery including the steps of: introducing into the eye as an aqueous/vitreous substitute, in order to protect internal eye tissues, a viscoelastic composition which comprises a solution of a cellulose derivative and polyethylene oxide (PEO in a physiologically compatible liquid, the composition being physiologically compatible with the intraocular surfaces of eye of the mammal; and performing the ophthalmic surgery.
Claim 3
Dependent Claim 88 words
The method of protecting the intraocular surfaces of an eye of a mammal during ophthalmic surgery in accordance with claim 1 wherein the introducing step includes: introducing into the eye as an aqueous/vitreous substitute, in order to protect internal eye tissues, a viscoelastic composition which comprises a solution of at least about 1% by weight of a cellulose derivative, and about 10 ppm to 300 ppm polyethylene oxide (PEO) in a physiologically compatible liquid, the composition being physiologically compatible with the intraocular surfaces of eye of the mammal.
Claim 4
Dependent Claim 34 words
The method of claim 1 including the step of: coating the surgical instruments with the same viscoelastic composition that is introduced into the eye in order to protect the eye tissue during ophthalmic surgery.
Claim 5
Dependent Claim 25 words
The method of claim 1 including the step of: aspirating the viscoelastic composition initially introduced into the eye after the ophthalmic surgery has been performed.
Claim 6
Dependent Claim 29 words
The method of claim 1 wherein the introducing step includes: introducing the viscoelastic composition wherein the derivative is hydroxypropylmethylcellulose and the concentration of hydroxypropylmethylcellulose is about 2% to 21/2%.
Claim 7
Dependent Claim 25 words
The method of claim 1 wherein the introducing step includes: introducing the viscoelastic composition wherein the concentration of the polyethylene oxide is about 300 ppm.
Claim 8
Dependent Claim 31 words
The method of claim 1 wherein the introducing step includes: introducing the viscoelastic composition wherein the cellulose derivation is methylcellulose and the polyethylene oxide is about 10 ppm to 100 ppm.
Claim 9
Dependent Claim 27 words
The method of claim 1 wherein the introducing step includes: introducing the viscoelastic composition wherein the polyethylene oxide has a concentration of about 10 to 100 ppm.
Claim 10
Dependent Claim 45 words
The method of claim 1 including the steps of: preparatory to the step of performing the ophthalmic surgery, topically wetting the eye with the viscoelastic composition used in the introducing step; and during the ophthalmic surgery, periodically topically wetting the eye with the viscoelastic composition.

References Cited (Backward Citations)

US3947573A Cited
US3856919A Cited
US4629623A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1994-11-25 1995-05-27 1995-11-26 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1998-11-25 1999-05-27 1999-11-26 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2002-11-25 2003-05-27 2003-11-26 $7700.00 Window Closed / Lapsed

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