US5064653A — Hydrophilic foam compositions

Claim 1

Independent Claim 99 words

A hydrophilic foam composition comprising the in situ reaction product of: a) an isocyanate-capped polyether prepolymer, b) a polymeric hydrophilic agent capable of absorbing water, c) an adjuvant comprising an alcohol selected from the group consisting of water soluble monols, diols and polyhydric alcohols, d) a wetting agent, and e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.

Claim 2

Dependent Claim 99 words

A hydrophilic foam composition comprising the in situ reaction product of: a) an isocyanate-capped polyether prepolymer, b) a polymeric hydrophilic agent capable of absorbing water, c) an adjuvant comprising an alcohol selected from the group consisting of water soluble monols, diols and polyhydric alcohols, d) a wetting agent, and e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.

Claim 3

Dependent Claim 39 words

The hydrophilic foam composition of claim 1 wherein said prepolymer is a member selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 3.0 meq/g and mixtures thereof.

Claim 4

Dependent Claim 31 words

The hydrophilic foam composition of claim 1 wherein said prepolymer is present in an amount of from about 20 wt. % to about 60 wt. % of the total reactant composition.

Claim 5

Dependent Claim 29 words

The hydrophilic foam composition of claim 1 wherein said prepolymer is present in an amount of from about 45 to about 50 wt. % of the total reactant composition.

Claim 6

Dependent Claim 37 words

The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is an absorptive polymer capable of absorbing water and having a fluid uptake of at least about 50 ml of water per gram of said polymer.

Claim 7

Dependent Claim 32 words

The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is an absorptive polymer having a fluid uptake of at least about 100 ml of water per gram of said polymer.

Claim 8

Dependent Claim 32 words

The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is an absorptive polymer having a fluid uptake of at least about 150 ml of water per gram of said polymer.

Claim 9

Dependent Claim 37 words

The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts, and mixtures thereof.

Claim 10

Dependent Claim 34 words

The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is present in an amount sufficient to provide a foam composition capable of absorbing at least about 3 times its weight of liquid.

Claim 11

Dependent Claim 34 words

The hydrophilic foam composition of claim 8 wherein said hydrophilic agent is present in an amount sufficient to provide a foam composition capable of absorbing at least about 3 times its weight of liquid.

Claim 12

Dependent Claim 25 words

The hydrophilic foam composition of claim 9 wherein said foam composition is capable of tightly carrying at least about 3 times its weight of liquid.

Claim 13

Dependent Claim 25 words

The hydrophilic foam composition of claim 10 wherein said foam composition is capable of tightly carrying at least about 3 times its weight of liquid.

Claim 14

Dependent Claim 13 words

The hydrophilic foam composition of claim 1 wherein said alcohol is a monol.

Claim 15

Dependent Claim 13 words

The hydrophilic foam composition of claim 1 wherein said alcohol is a diol.

Claim 16

Dependent Claim 14 words

The hydrophilic foam composition of claim 1 wherein said alcohol is a polyhydric alcohol.

Claim 17

Dependent Claim 20 words

The hydrophilic foam composition of claim 15 wherein said polyhydric alcohol has a molecular weight of less than about 1000.

Claim 18

Dependent Claim 36 words

The hydrophilic foam composition of claim 1 wherein said alcohol is a member selected from the group consisting of isopropyl alcohol, ethanol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof.

Claim 19

Dependent Claim 12 words

The hydrophilic foam composition of claim 10 wherein said alcohol is glycerin.

Claim 20

Dependent Claim 28 words

The hydrophilic foam composition of claim 1 wherein said alcohol is present in an amount of from about 5% to about 30% by weight of the reactant composition.

Claim 21

Dependent Claim 43 words

The hydrophilic foam composition of claim 1 wherein said wetting agent is a non-ionic surfactant selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof.

Claim 22

Dependent Claim 29 words

The hydrophilic foam composition of claim 20 wherein said wetting agent is present in an amount of from about 1% to about 10% by weight of said reactant composition.

Claim 23

Dependent Claim 60 words

The hydrophilic foam composition of claim 1 wherein said prepolymer, said hydrophilic agent and said adjuvant are present in the reactant composition such that the ratio of prepolymer to hydrophilic agent is in the range of from about 20:1 to about 20:10 and the ratio of prepolymer to adjuvant is in the range of from about 20:2 to about 20:30.

Claim 24

Dependent Claim 175 words

A hydrophilic foam composition comprising the in situ reaction product of : a) an isocyanate-capped polyether prepolymer, wherein said prepolymer is a member selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 3.0 meq/g, b) a hydrophilic agent capable of absorbing water, said hydrophilic agent being a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts and mixtures thereof; c) an adjuvant comprising an alcohol, said adjuvant being a member selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4- butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof; said reactant composition (d) including a wetting agent selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof, and e) water, said water being a member selected from the group consisting of deionized water, distilled water and normal saline.

Claim 25

Dependent Claim 175 words

A hydrophilic foam composition comprising the in situ reaction product of : a) an isocyanate-capped polyether prepolymer, wherein said prepolymer is a member selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 3.0 meq/g, b) a hydrophilic agent capable of absorbing water, said hydrophilic agent being a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts and mixtures thereof; c) an adjuvant comprising an alcohol, said adjuvant being a member selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4- butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof; said reactant composition (d) including a wetting agent selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof, and e) water, said water being a member selected from the group consisting of deionized water, distilled water and normal saline.

Claim 26

Dependent Claim 70 words

The hydrophilic foam composition of claim 23 wherein said prepolymer is an isocyanate-capped polyether prepolymer having an isocyanate equivalent weight of about 1.6 meq/g and an equivalent weight per isocyanato group of about 625; said hydrophilic agent is starch-g-poly(2-propenamide-co-2-propenoic acid, mixed sodium and aluminum salt); said adjuvant comprises glycerine, and said wetting agent is a member selected from the group consisting of block copolymers of ethylene oxide and propylene oxide.

Claim 27

Dependent Claim 98 words

A wound dressing comprising the in situ reaction product of: a) an isocyanate-capped polyether prepolymer, b) a polymeric hydrophilic agent capable of absorbing water, c) an adjuvant comprising an alcohol selected from the group consisting of water soluble monols, diols and polyhydric alcohols, d) a wetting agent, and e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.

Claim 28

Dependent Claim 98 words

A wound dressing comprising the in situ reaction product of: a) an isocyanate-capped polyether prepolymer, b) a polymeric hydrophilic agent capable of absorbing water, c) an adjuvant comprising an alcohol selected from the group consisting of water soluble monols, diols and polyhydric alcohols, d) a wetting agent, and e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.

Claim 29

Dependent Claim 194 words

A wound dressing composition comprising the in situ reaction product of: a) an isocyanate-capped polyether prepolymer selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 7.5 meq/g, b) a hydrophilic agent capable of absorbing water selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts, and mixtures thereof, c) an adjuvant comprising an alcohol selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof, d) a wetting agent selected from the group consisting of block copolymers of ethylene oxide and propyleneoxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids, and mixtures thereof, and e) water selected from the group consisting of deionized water, distilled water, and normal saline, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.

Claim 30

Dependent Claim 194 words

A wound dressing composition comprising the in situ reaction product of: a) an isocyanate-capped polyether prepolymer selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 7.5 meq/g, b) a hydrophilic agent capable of absorbing water selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts, and mixtures thereof, c) an adjuvant comprising an alcohol selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof, d) a wetting agent selected from the group consisting of block copolymers of ethylene oxide and propyleneoxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids, and mixtures thereof, and e) water selected from the group consisting of deionized water, distilled water, and normal saline, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.

Claim 31

Dependent Claim 216 words

A wound dressing comprising a hydrophilic foam composition comprising the in situ reaction product of (a) an isocyanate-capped polyether prepolymer having an isocyanate equivalent weight of from about 0.5 meq/g to about 3 meq/g; (b) a hydrophilic agent capable of absorbing water and having a fluid uptake of at least about 50 ml of water per gram of said agent, and wherein said hydrophilic agent comprises a hydrophilic material which is a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts and mixtures thereof; (c) an adjuvant comprising an alcohol selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, pentaerythritol sorbitol, and mixtures thereof; (d) a wetting agent comprising a non-ionic surfactant selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof; and (e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released from said foam composition in the presence of the external liquid.

Claim 32

Dependent Claim 216 words

A wound dressing comprising a hydrophilic foam composition comprising the in situ reaction product of (a) an isocyanate-capped polyether prepolymer having an isocyanate equivalent weight of from about 0.5 meq/g to about 3 meq/g; (b) a hydrophilic agent capable of absorbing water and having a fluid uptake of at least about 50 ml of water per gram of said agent, and wherein said hydrophilic agent comprises a hydrophilic material which is a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts and mixtures thereof; (c) an adjuvant comprising an alcohol selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, pentaerythritol sorbitol, and mixtures thereof; (d) a wetting agent comprising a non-ionic surfactant selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof; and (e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released from said foam composition in the presence of the external liquid.

Claim 33

Dependent Claim 23 words

The wound dressing of claim 27 wherein said water is selected from the group consisting of deionized water, distilled water and normal saline.

Claim 34

Dependent Claim 34 words

The wound dressing of claim 25 wherein said hydrophilic agent comprises an additive selected from the group consisting of methylcellulose, guar gum, pectin, karaya gum, chitosan, agar, acacia powder, carrageenan, gelatin, and mixtures thereof.

Claim 35

Dependent Claim 13 words

The wound dressing of claim 25 wherein said adjuvant comprises a therapeutic agent.

Claim 36

Dependent Claim 12 words

The wound dressing of claim 25 wherein said adjuvant comprises a medicament.

Claim 37

Dependent Claim 12 words

The wound dressing of claim 25 wherein said adjuvant comprises a cosmetic.

Claim 38

Dependent Claim 42 words

The wound dressing of claim 30 wherein said therapeutic agent is selected from the group consisting of soluble collagen, hydrolyzed collagen, collagen amino acids salt free, hydrolyzed animal protein and hyaluronic acid, an ointment including methyl salicylate and menthol and hydrocortisone acetate.

Claim 39

Dependent Claim 35 words

The wound dressing of claim 32 wherein said cosmetic is selected from the group consisting of collagen complex, liposomes, bath oil, a lotion, a cream, a herbal and aloe lotion, an ointment and tretinoin cream.

Claim 40

Dependent Claim 65 words

The wound dressing of claim 27 wherein said isocyanate-capped polyether prepolymer has an isocyanate equivalent weight of about 1.6 meq/g and an equivalent weight per isocyanato group of about 625; said hydrophilic agent is starch-g-poly(2-propenamide-co-2-propenoic acid, mixed sodium and aluminum salt), said adjuvant comprises glycerin, said wetting agent is a member selected from the group consisting of block copolymers of ethylene oxide and propylene oxide.

Claim 41

Dependent Claim 59 words

The wound dressing of claim 35 wherein said prepolymer, said hydrophilic agent and said adjuvant are present in the reactant composition such that the ratio of prepolymer o hydrophilic agent is in the range of from about 20:1 to about 20:10 and the ratio of prepolymer to adjuvant is in the range of from about 20:2 to about 20:30.

Claim 42

Dependent Claim 19 words

A method for treating a wound comprising applying to the wound a wound dressing as claimed in claim 25.

Claim 43

Dependent Claim 19 words

A method for treating a wound comprising applying to the wound a wound dressing as claimed in claim 27.

Claim 44

Dependent Claim 19 words

A method for treating a wound comprising applying to the wound a wound dressing as claimed in claim 35.

Claim 45

Dependent Claim 59 words

The hydrophilic foam composition of claim 23 wherein said prepolymer, said hydrophilic agent and said adjuvant are present in the reactant composition such that the ratio of prepolymer to hydrophilic agent is in the range of from about 20:1 to about 20:10 and the ratio of prepolymer to adjuvant is in the range of from about 20:2 about 20:30.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1994-11-11	1995-05-13	1995-11-12	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1998-11-11	1999-05-13	1999-11-12	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2002-11-11	2003-05-13	2003-11-12	$7700.00	Window Closed / Lapsed

Hydrophilic foam compositions

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