EP0184233A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Drug dispensing wound dressing
Assignee: Thermo Fisher Scientific Inc
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Filing: 1985-10-24
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Granted: —
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Expires: 2005-10-24
Abstract
Abstract The disclosed wound dressings have a drug dispersed throughout a polyurethane matrix that is the reaction product of: (A) An isocyanate terminated prepolymer formed by reaction of isophorone diisocyanate and a macroglycol and (B) a monomer containing hydroxyl and vinyl groups. The reaction product is a vinyl terminated polyurethane oligomer which is liquid at room temperature and which may be readily admixed with a pharmacoactive substance and a photosensitizer, formed into a film and cured by exposure to UV light without release of heat. In the most preferred embodiments the foregoing oligomer is codissolved in an organic solvent with a polyurethane polymer which is the reaction product of: dicyclohexyl methane diisocyanate; a polytetramethylene ether polyol having a molecular weight in the range of 1000-3000 Daltons; and 1,4-butane diol. That solution is then admixed with the pharmacoactive agent, formed into a film and cured.
Inventors
- 👤 Michael Szycher
- 👤 Donald J. Dempsey
- 👤 Jonathan L. Rolfe
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 09:43
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/44; A61L15/22; A61L15/26; A61F; A61F13/00; A61F13/15; A61F13/53; A61F2013/530007; A61L2300/00; A61L2300/40; A61L2300/402; A61L2300/404; A61L2300/41; A61L2300/418
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
121 words
A wound dressing comprising a drug-dispensing elastomeric film, said film comprising the reaction product formed by: a. reacting isophorone diisocyanate and a macroglycol having a molecular weight of 500-5000 daltons together in the presence of a catalyst to form an isocyanate terminated prepolymer; b. reacting said prepolymer with a monomer containing hydroxyl and vinyl groups to form an ultraviolet-curable, vinyl terminated polyurethane oligomer; c. admixing said oligomer with 1-10 wt. % of a pharmacoactive agent, based on the weight of the oligomer, selected from the group consisted of coagulants, antibiotics, antifungals, topical anesthetics, anti-inflammatories and mixtures thereof, to form an UV-curable homogeneous blend; and wherein said UV-curable' homogeneous mixture is formed into a film and cured by exposure to ultraviolet light.
Claim 2
Dependent Claim
121 words
A wound dressing comprising a drug-dispensing elastomeric film, said film comprising the reaction product formed by: a. reacting isophorone diisocyanate and a macroglycol having a molecular weight of 500-5000 daltons together in the presence of a catalyst to form an isocyanate terminated prepolymer; b. reacting said prepolymer with a monomer containing hydroxyl and vinyl groups to form an ultraviolet-curable, vinyl terminated polyurethane oligomer; c. admixing said oligomer with 1-10 wt. % of a pharmacoactive agent, based on the weight of the oligomer, selected from the group consisted of coagulants, antibiotics, antifungals, topical anesthetics, anti-inflammatories and mixtures thereof, to form an UV-curable homogeneous blend; and wherein said UV-curable' homogeneous mixture is formed into a film and cured by exposure to ultraviolet light.
Claim 3
Dependent Claim
78 words
The wound dressing of claim 1 wherein the vinyl terminated oligomer is co-dissolved, in an organic solvent, with a polyurethane polymer which is the reaction product of: d) dicyclohexyl methane diisocyanate; e) a polytetramethylene ether polyol having a molecular weight in the range of 1000-3000 daltons; and f) 1,4-butane diol; and the resulting solution is formed into said film comprising 80-99 parts by weight of said vinyl terminated oligomer and 1-20 parts by weight of said polyurethane polymer.
Claim 4
Dependent Claim
28 words
The wound dressing of claim 2 further comprising a textile fabric, wherein said fabric is first coated with said polyurethane polymer and then coated with said solvent solution.
Claim 5
Dependent Claim
188 words
A process for forming a drug-dispensing wound dressing comprising: 1) reacting (a) isophorone diisocyanate and (b) a macroglycol having a molecular weight of 500-5000 daltons in the presence of a catalyst to form an isocyanate terminated prepolymer; 2) reacting said prepolymer with a sufficient amount of (c) a monomer containing hydroxyl and vinyl groups to form an ultraviolet-curable, vinyl terminated polyurethane liquid oligomer in which only compounds with a molecular weight of 1500-5000 are present; 3) admixing said vinyl terminated oligomer with 1-10% by weight of a drug, based on the weight of said oligomer, said drug selected from the group consisisting of coagulants, antibiotics, antifungals, topical anesthetics, anti-inflammatories and mixtures thereof, to form an UV-curable mixture; 4) forming the UV-curable mixture into a film; and 5) curing said film by exposure to ultraviolet light. 5. The wound dressing of claim 1 or 2 or formed by the process of claim 4 wherein a photoinitiator is admixed with said oligomer, said photoinitiator being selected from the group consisting of diacetoxyacetobenzophenone, benzophenone, diethoxyacetophenone 4-morpholine benzophenone, 4-aminobenzophenone and 4 1- methoxyacetophenone and wherein said curing is at approximately room temperature.
Claim 6
Dependent Claim
27 words
A process in accordance with claim 4 wherein said vinyl terminated oligomer is dissolved in an organic solvent and the drug is admixed in said solvent solution.
Claim 7
Dependent Claim
73 words
A process in accordance with claim 6 wherein the vinyl terminated oligomer is co-dissolved, in an organic solvent, with a polyurethane polymer which is the reaction product of: d) dicyclohexyl methane diisocyanate; e) a polytetramethylene ether polyol having a molecular weight in the range of 1000-3000 daltons; and f) 1,4-butane diol; and wherein 80-99 parts by weight of said vinyl terminated oligomer are co-dissolved with 1-20 parts by weight of said polyurethane polymer.
Claim 8
Dependent Claim
25 words
The process of claim 8 further comprising a textile fabric which is first coated with said polyurethane polymer and then coated with said solvent solution.
Claim 9
Dependent Claim
33 words
The wound dressing of claim 1 or 2 or formed by the process of claim 4 or 7 further comprising a coating of a pressure sensitive adhesive on one surface of said film.
Claim 10
Dependent Claim
40 words
The wound dressing of claim 1 or 2 or formed by the process of claim 4 or 7 wherein said film further comprises at least one non-reactive thixotropic agent, selected from the group consisting of pyrogenic silica and bentonite clays.
References Cited (Backward Citations)
No citation records indexed.
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