US5061738A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blood compatible, lubricious article and composition and method therefor
Assignee: Becton Dickinson and Co
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Filing: 1991-01-11
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Granted: 1991-10-29
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Expires: 2011-01-11
Abstract
Abstract A leach resistant composition includes a quaternary ammonium complex of heparin and a silicone. A method for applying a coating of the composition to a surface of a medical article is within the purview of the present invention. Medical articles having surfaces which are both lubricious and antithrombogenic, are produced in accordance with the method hereof.
Inventors
- 👤 Donald D. Solomon
- 👤 Robert A. Taller
- 👤 Victor A. Williamitis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:39
CPC Classifications
C; C08; C08L; C08L83/00; C08L83/04; A; A61; A61L; A61L29/00; A61L29/08; A61L29/085; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017; A61L33/0029; A61L33/0047; A61L2400/00; A61L2400/10
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
106 words
A medical device for contact with a blood stream comprising an article having coated thereon a composition comprising a mixture of a quaternary ammonium complex of heparin and about 2 to 75% by weight of a noncuring lubricating silicone, said complex having the formula ##STR3## wherein R 1 , R 2 , R 3 and R 4 are independently selected from the group consisting of an alkyl group of 1 to about 18 carbon atoms and an aralkyl group of about 7 to 18 carbon atoms and H - is a negative ion of heparin, said silicone having a viscosity of about 20 to 1,000,000 centistokes.
Claim 2
Dependent Claim
106 words
A medical device for contact with a blood stream comprising an article having coated thereon a composition comprising a mixture of a quaternary ammonium complex of heparin and about 2 to 75% by weight of a noncuring lubricating silicone, said complex having the formula ##STR3## wherein R 1 , R 2 , R 3 and R 4 are independently selected from the group consisting of an alkyl group of 1 to about 18 carbon atoms and an aralkyl group of about 7 to 18 carbon atoms and H - is a negative ion of heparin, said silicone having a viscosity of about 20 to 1,000,000 centistokes.
Claim 3
Dependent Claim
15 words
The device of claim 1 wherein said viscosity is from about 1,000 to 60,000 centistokes.
Claim 4
Dependent Claim
46 words
The device of claim 1 wherein R 1 , R 2 and R 3 are independently alkyl groups selected from the group having 8 to 18 carbon atoms and R 4 is an alkyl group selected from the group having from 1 to 4 carbon atoms.
Claim 5
Dependent Claim
11 words
The device of claim 1 wherein said article is a catheter.
Claim 6
Dependent Claim
12 words
The device of claim 1 wherein said device is a catheter introducer.
Claim 7
Dependent Claim
116 words
A medical device of claim 1 for contact with a blood stream comprising a shaped article having coated thereon a composition comprising a mixture of a quaternary ammonium complex of heparin and about 20 to 50% by weight of a noncuring lubricating polydimethylsiloxane, said complex having the formula ##STR4## wherein R 1 , R 2 and R 3 are independently selected from the group consisting of a straight chain alkyl group of 8 to 18 carbon atoms, R 4 is selected from the group consisting of a lower alkyl group of 1 to 4 carbon atoms and H - is a negative ion of heparin, said polydimethylsiloxane having a viscosity of about 1,000 to 60,000 centistokes.
References Cited (Backward Citations)
US4326532A
Cited
US4529614A
Cited
US4678468A
Cited
US4676975A
Cited
US4720521A
Cited
US4925668A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-10-28 | 1995-04-29 | 1995-10-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-10-28 | 1999-04-29 | 1999-10-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-10-28 | 2003-04-29 | 2003-10-29 | $7700.00 | Window Closed / Lapsed |