US4676975A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Thermoplastic polyurethane anticoagulant alloy coating
Assignee: Becton Dickinson and Co
•
Filing: 1984-12-07
•
Granted: 1987-06-30
•
Expires: 2004-12-07
Abstract
Abstract An antithrombogenic thermoplastic polyurethane product and process for preparing the same which comprises a substrate and at least one layer of a polyurethane alloy complex comprising a thermoplastic polyurethane and completely dispersed therein a preformed complex of an antithrombogenic material ionically bonded with a quaternary ammonium compound.
Inventors
- 👤 Charles W. McGary
- 👤 Donald D. Solomon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:27
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L27/00; A61L27/50; A61L27/54; A61L29/00; A61L29/14; A61L29/16; C; C09; C09D; C09D175/00; C09D175/04; A61L2300/00; A61L2300/20; A61L2300/22; A61L2300/23; A61L2300/232; A61L2300/236; A61L2300/40; A61L2300/42; Y; Y10; Y10S; Y10S128/00; Y10S128/22
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
110 words
A thermoplastic polyurethane product possessing long-term antithrombogenic properties, comprising (a) a polyurethane alloy complex formed in an organic solvent solution; (b) said polyurethane alloy complex including (1) a thermoplastic polyurethane; (2) a material dispersed throughout said thermoplastic polyurethane; (3) said dispersed material being an antithrombogenic material; (4) said dispersed material ionically bonded to said thermoplastic polyurethane by a quaternary ammonium compound; (c) a solid polyurethane substrate separate from said thermoplastic polyurethane in said polyurethane alloy complex comprised of a material not soluble in said organic solvent solution for said polyurethane alloy complex; and (d) said polyurethane alloy complex being in the form of a surface layer on said polyurethane substrate.
Claim 2
Dependent Claim
110 words
A thermoplastic polyurethane product possessing long-term antithrombogenic properties, comprising (a) a polyurethane alloy complex formed in an organic solvent solution; (b) said polyurethane alloy complex including (1) a thermoplastic polyurethane; (2) a material dispersed throughout said thermoplastic polyurethane; (3) said dispersed material being an antithrombogenic material; (4) said dispersed material ionically bonded to said thermoplastic polyurethane by a quaternary ammonium compound; (c) a solid polyurethane substrate separate from said thermoplastic polyurethane in said polyurethane alloy complex comprised of a material not soluble in said organic solvent solution for said polyurethane alloy complex; and (d) said polyurethane alloy complex being in the form of a surface layer on said polyurethane substrate.
Claim 3
Dependent Claim
29 words
The thermoplastic polyurethane product of claim 1, wherein the weight ratio of said thermoplastic polyurethane to said dispersed material is within the range of between about 10:1 and 1:5.
Claim 4
Dependent Claim
26 words
The antithrombogenic thermoplastic polyurethane product of claim 1 wherein the antithrombogenic material is selected from the group consisting of heparin, prostaglandins, sulfated polysaccharide, and mixtures thereof.
Claim 5
Dependent Claim
37 words
The antithrombogenic thermoplastic polyurethane product of claim 1 wherein the quaternary ammonium compound is a long-chain alkyl quaternary ammonium salt having from 2 to 4 alkyl groups each having from about 10 to about 30 carbon atoms.
Claim 6
Dependent Claim
30 words
The antithrombogenic, thermoplastic polyurethane product of claim 1 wherein the quaternary ammonium compound is selected from the group consisting of tridodecylmethyl ammonium salts, tetradodecyl ammonium salts and tridodecylbenzyl ammonium salts.
Claim 7
Dependent Claim
22 words
The antithrombogenic thermoplastic polyurethane product of claim 1 wherein a crosslinking agent is employed to render the polyurethane product thermosetting in nature.
Claim 8
Independent Claim
166 words
A method for producing a thermoplastic polyurethane product possessing long-term antithrombogenic properties, comprising the steps of (a) selecting a thermoplastic polyurethane; (b) selecting an antithrombogenic material; (c) selecting a quaternary ammonium compound; (d) coupling said material from step (b) with said quaternary ammonium compound from (c); (e) adding said thermoplastic polyurethane from step (a) and said material from step (d) to an organic solvent solution; (f) dispersing said material step (d) throughout said material from step (a) to form a polyurethane alloy complex solution; (g) selecting a solid article comprised of a polyurethane not soluble in said organic solvent solution from step (e) (h) coating the surface of said solid article from step (g) with said solution from step (f); and (i) removing said solvent solution from the coated surface formed in step (h) to form a solid substrate of said article comprised of polyurethane having disposed on the surface thereof a layer of an alloy complex including polyurethane separate from the polyurethane in said article.
Claim 9
Independent Claim
166 words
A method for producing a thermoplastic polyurethane product possessing long-term antithrombogenic properties, comprising the steps of (a) selecting a thermoplastic polyurethane; (b) selecting an antithrombogenic material; (c) selecting a quaternary ammonium compound; (d) coupling said material from step (b) with said quaternary ammonium compound from (c); (e) adding said thermoplastic polyurethane from step (a) and said material from step (d) to an organic solvent solution; (f) dispersing said material step (d) throughout said material from step (a) to form a polyurethane alloy complex solution; (g) selecting a solid article comprised of a polyurethane not soluble in said organic solvent solution from step (e) (h) coating the surface of said solid article from step (g) with said solution from step (f); and (i) removing said solvent solution from the coated surface formed in step (h) to form a solid substrate of said article comprised of polyurethane having disposed on the surface thereof a layer of an alloy complex including polyurethane separate from the polyurethane in said article.
Claim 10
Dependent Claim
16 words
The method of claim 2, wherein said article selected in step (g) is a vascular catheter.
Claim 11
Dependent Claim
23 words
The method of claim 7 wherein the antithrombogenic material is selected from the group consisting of heparin, prostaglandins, sulfated polysaccharide, and mixtures thereof.
Claim 12
Dependent Claim
35 words
The method of claim 7 wherein the quaternary ammonium compound is a long chain alkyl quaternary ammonium salt having from 2 to 4 alkyl groups each having from about 10 to about 30 carbon atoms.
Claim 13
Dependent Claim
27 words
The method of claim 7 wherein the quaternary ammonium compound is selected from the group consisting of tridodecylmethyl ammonium salts, tetradodecyl ammonium salts, and tridodecylbenzyl ammonium salts.
Claim 14
Dependent Claim
22 words
The method of claim 7 wherein the contacting is performed by dipping the substrate into the organic solvent containing the prefromed complex.
Claim 15
Dependent Claim
22 words
The method of claim 7 wherein the solvent is removed from the polyurethane product by heating the product to volatize the solvent.
References Cited (Backward Citations)
US3617344A
Cited
US3457098A
Cited
US3846353A
Cited
US3853804A
Cited
US3844989A
Cited
US4118485A
Cited
FR2364939A2
Cited
US4349467A
Cited
US4302368A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-29 | 1990-12-29 | 1991-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-29 | 1994-12-29 | 1995-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-29 | 1998-12-29 | 1999-06-30 | $7700.00 | Window Closed / Lapsed |