US5057494A
Expired / Lapsed
US
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Method for preventing tissue damage after an ischemic episode
Assignee: Ethicon Inc
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Filing: 1988-08-03
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Granted: 1991-10-15
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Expires: 2008-08-03
Abstract
Abstract A method is provided for preventing tissue damage in a patient after the tissue has been deprived of blood supply resulting in ischemia. The method involves administering to the patient a polypeptide having epidermal growth factor activity or fibroblast growth factor activity prior to or after the ischemic event.
Inventors
- 👤 Warren D. Sheffield
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 16:54
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/1825; A61K31/00; A61K38/1808; A61P; A61P43/00; A61P9/00; A61P9/10
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
49 words
A method for preventing tissue damage in a patient after the tissue has been deprived of blood supply for a tissue damaging amount of time, comprising administering to the patient an effective amount of polypeptide having epidermal growth factor activity so as to contact the blood deprived tissue therewith.
Claim 2
Independent Claim
49 words
A method for preventing tissue damage in a patient after the tissue has been deprived of blood supply for a tissue damaging amount of time, comprising administering to the patient an effective amount of polypeptide having epidermal growth factor activity so as to contact the blood deprived tissue therewith.
Claim 3
Dependent Claim
28 words
The method of claim 1, wherein the tissue is selected from the group consisting of neuronal tissue, myocardial tissue, lung tissue, spleen tissue, intestinal tissue or renal tissue.
Claim 4
Dependent Claim
12 words
The method of claim 1, wherein the polypeptide is epidermal growth factor.
Claim 5
Dependent Claim
16 words
The method of claim 1, wherein the contacting is achieved by intravenous administration of the polypeptide.
Claim 6
Dependent Claim
24 words
The method of claim 1, wherein a fibrinolytic agent is administered to the patient prior to or simultaneously with the administration of the polypeptide.
Claim 7
Dependent Claim
26 words
The method of claim 1, wherein a free radical scavenger material is administered to the patient Prior to or simultaneously with the administration of the polypeptide.
Claim 8
Independent Claim
58 words
A method for preventing tissue damage in a patient resulting from the deprivation of blood supply to the tissue for a tissue damaging amount of time, comprising administering to the patient, prior to the blood supply deprivation to the tissue, an effective amount of a polypeptide having epidermal growth factor activity so as to contact the tissue therewith.
Claim 9
Independent Claim
58 words
A method for preventing tissue damage in a patient resulting from the deprivation of blood supply to the tissue for a tissue damaging amount of time, comprising administering to the patient, prior to the blood supply deprivation to the tissue, an effective amount of a polypeptide having epidermal growth factor activity so as to contact the tissue therewith.
Claim 10
Independent Claim
43 words
A method for preventing reperfusion injury to tissue in a patient after the tissue has suffered from ischemia, comprising administering to the patient a polypeptide having epidermal growth factor activity in a reperfusion injury Preventing amount so as to contact the tissue therewith.
Claim 11
Independent Claim
43 words
A method for preventing reperfusion injury to tissue in a patient after the tissue has suffered from ischemia, comprising administering to the patient a polypeptide having epidermal growth factor activity in a reperfusion injury Preventing amount so as to contact the tissue therewith.
Claim 12
Independent Claim
30 words
A method for treating cerebrovascular disease in a patient resulting from an ischemic event, comprising administering to the patient an effective amount of a polypeptide having epidermal growth factor activity.
Claim 13
Independent Claim
30 words
A method for treating cerebrovascular disease in a patient resulting from an ischemic event, comprising administering to the patient an effective amount of a polypeptide having epidermal growth factor activity.
Claim 14
Independent Claim
53 words
A method for preventing tissue damage in a patient after the tissue has been deprived of blood supply for a tissue damaging amount of time, comprising: a) administering to the patient a fibrinolytic agent, and followed by b) administering to the patient an effective amount of a polypeptide having epidermal growth factor activity.
Claim 15
Independent Claim
53 words
A method for preventing tissue damage in a patient after the tissue has been deprived of blood supply for a tissue damaging amount of time, comprising: a) administering to the patient a fibrinolytic agent, and followed by b) administering to the patient an effective amount of a polypeptide having epidermal growth factor activity.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-10-14 | 1995-04-15 | 1995-10-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-10-14 | 1999-04-15 | 1999-10-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-10-14 | 2003-04-15 | 2003-10-15 | $7700.00 | Window Closed / Lapsed |