Patent US4233972A successfully refreshed from Google Patents.
US4845075A
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Biologically active B-chain homodimers
Assignee: Zymogenetics Inc
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Filing: 1986-12-15
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Granted: 1989-07-04
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Expires: 2006-12-15
Abstract
Abstract Dimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the protein may have two substantially identical polypeptide chains, each of the chains being substantially homologous to the B-chain of PDGF. Alternatively, the protein may have two polypeptide chains that are substantially identical to the B-chain of PDGF. In addition, proteins comprising polypeptides that are variants or derivatives of the B-chain of PDGF are also disclosed. Therapeutic compositions containing these proteins and methods for enhancing the wound-healing process in warm-blooded animals are also disclosed.
Inventors
- 👤 Mark J. Murray
- 👤 James D. Kelly
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:45
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; C07K14/435; C07K14/475; C07K14/49; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/62; C12N15/625; C12N15/63; C12N15/67; C12N15/74; C12N15/78; C12N15/79; C12N15/80; C12N15/81; A61K38/00; C07K2319/00; C07K2319/01; C07K2319/02; C07K2319/036; C07K2319/70; C07K2319/74; C07K2319/75; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/11011; C12N2740/11022; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/12; Y10S930/22; Y10S930/221
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 15 to amino acid 109.
Claim 2
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 15 to amino acid 109.
Claim 3
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 29 to amino acid 109.
Claim 4
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 29 to amino acid 109.
Claim 5
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 15 to amino acid 101.
Claim 6
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 15 to amino acid 101.
Claim 7
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 29 to amino acid 101.
Claim 8
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 29 to amino acid 101.
Claim 9
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 1 to amino acid 101.
Claim 10
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 1 to amino acid 101.
Claim 11
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 1 to amino acid 109.
Claim 12
Dependent Claim
29 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of the B-chain of PDGF from amino acid 1 to amino acid 109.
Claim 13
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 15 to amino acid 109.
Claim 14
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 15 to amino acid 109.
Claim 15
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 29 to amino acid 109.
Claim 16
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 29 to amino acid 109.
Claim 17
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 15 to amino acid 101.
Claim 18
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 15 to amino acid 101.
Claim 19
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 29 to amino acid 101.
Claim 20
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 29 to amino acid 101.
Claim 21
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 1 to amino acid 101.
Claim 22
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 1 to amino acid 101.
Claim 23
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 1 to amino acid 109.
Claim 24
Dependent Claim
32 words
An isolated protein having two polypeptide chains, each of said chains comprising the amino acid sequence of p28-sis corresponding to the B-chain of PDGF from amino acid 1 to amino acid 109.
Claim 25
Dependent Claim
26 words
A wound-healing composition comprising a therapeutically effective amount of an isolated protein according to any one of claims 1-12, and a physiologically acceptable carrier or diluent.
Claim 26
Dependent Claim
23 words
The wound-healing composition of claim 13 wherein the carrier or diluent is selected from the group consisting of albumin, saline and sterile water.
Claim 27
Dependent Claim
9 words
The wound-healing composition of claim 13, including an adjuvant.
Claim 28
Dependent Claim
24 words
The wound-healing composition of claim 15 wherein the adjuvant is selected from the group consisting of collagen, hyaluronic acid preparations, fibronectin and factor XIII.
Claim 29
Independent Claim
26 words
A method for enhancing the wound healing process in a warm-blooded animal, comprising administering to the animal a composition according to any one of claims 13-16.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-07-03 | 1993-01-02 | 1993-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-03 | 1997-01-02 | 1997-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-03 | 2001-01-02 | 2001-07-04 | $7700.00 | Window Closed / Lapsed |