Patent US5054489A successfully refreshed from Google Patents.
US5054489A
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Magnetic resonance imaging using spatial modulation of magnetization
Assignee: TRUSTEES OF UNIVERSITY OF PENNSYLVANIA A NON-PROFIT CORP OF PENNSYLVANIA
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Filing: 1988-10-06
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Granted: 1991-10-08
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Expires: 2008-10-06
Abstract
Abstract A novel magnetic resonance imaging technique provides direct imaging of motion by spatially modulating the degree of magnetization prior to imaging. The pre-imaging pulse sequence consists of an RF pulse to produce transverse magnetization, a magnetic field gradient pulse to "wrap" the phase along the direction of the gradient and a second RF pulse to mix the modulated transverse magnetization with the longitudinal magnetization. The resulting images show periodic stripes due to the modulation. Motion between the time of striping and image formation is directly demonstrated as a corresponding displacement of the stripes. Applications include studies of heart wall motion and distinguishing slowly moving blood from thrombus.
Inventors
- 👤 Leon Axel
- 👤 Lawrence Dougherty
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 20:03
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/563; G01R33/56308; G01R33/56333; G01R33/567; G01R33/5673
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
103 words
A method of magnetic resonance imaging of a body portion of a patient, comprising the steps of: applying to the body portion an external magnetic field so as to produce a resultant magnetization; applying a pre-imaging sequence to the body portion so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation pattern of magnetization; applying an imaging sequence to the body portion to make visible said spatial modulation pattern of magnetization; and providing an image representing the intensity of magnetic resonance signals having said spatial modulation pattern of magnetization which are emitted from the patient.
Claim 2
Independent Claim
103 words
A method of magnetic resonance imaging of a body portion of a patient, comprising the steps of: applying to the body portion an external magnetic field so as to produce a resultant magnetization; applying a pre-imaging sequence to the body portion so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation pattern of magnetization; applying an imaging sequence to the body portion to make visible said spatial modulation pattern of magnetization; and providing an image representing the intensity of magnetic resonance signals having said spatial modulation pattern of magnetization which are emitted from the patient.
Claim 3
Dependent Claim
30 words
A method as in claim 1, wherein said pre-imaging sequence comprises a first radio-frequency pulse followed by a magnetic field gradient pulse which is followed by a second radio-frequency pulse.
Claim 4
Dependent Claim
33 words
A method as in claim 2, wherein said second radio-frequency pulse causes a magnetization change having a magnitude approximately equal to a magnitude of a magnetization change caused by said first radio-frequency pulse.
Claim 5
Dependent Claim
23 words
A method as in claim 2, wherein said pre-imaging sequence further comprises a second magnetic field gradient pulse after said second radio-frequency pulse.
Claim 6
Dependent Claim
48 words
A method as in claim 4, wherein said second magnetic field gradient pulse causes a magnetization wrap gradient in a different direction from that caused by said magnetic field gradient pulse and said pre-imaging sequence further comprises a third radio-frequency pulse after said second magnetic field gradient pulse.
Claim 7
Independent Claim
116 words
A method of detecting motion of a body portion of a patient using magnetic resonance imaging, comprising the steps of: applying to the body portion an external magnetic field so as to produce a resultant magnetization; applying a pre-imaging pulse sequence to the body portion, said pre-imaging pulse sequence comprising a first radio-frequency pulse followed by a magnetic field gradient pulse; applying an imaging sequence to the body portion to make visible intensity changes of said resultant magnetization caused by said pre-imaging sequence; and detecting motion of said body portion during a time interval between application of said pre-imaging and imaging sequences by examining said intensity changes of said resultant magnetization occurring during said time interval.
Claim 8
Independent Claim
116 words
A method of detecting motion of a body portion of a patient using magnetic resonance imaging, comprising the steps of: applying to the body portion an external magnetic field so as to produce a resultant magnetization; applying a pre-imaging pulse sequence to the body portion, said pre-imaging pulse sequence comprising a first radio-frequency pulse followed by a magnetic field gradient pulse; applying an imaging sequence to the body portion to make visible intensity changes of said resultant magnetization caused by said pre-imaging sequence; and detecting motion of said body portion during a time interval between application of said pre-imaging and imaging sequences by examining said intensity changes of said resultant magnetization occurring during said time interval.
Claim 9
Dependent Claim
22 words
A method as in claim 6, wherein said pre-imaging sequence further comprises a second radio-frequency pulse after said magnetic field gradient pulse.
Claim 10
Dependent Claim
33 words
A method as in claim 7, wherein said second radio-frequency pulse causes a magnetization change having a magnitude approximately equal to a magnitude of a magnetization change caused by said first radio-frequency pulse.
Claim 11
Dependent Claim
23 words
A method as in claim 7, wherein said pre-imaging sequence further comprises a second magnetic field gradient pulse after said second radio-frequency pulse.
Claim 12
Dependent Claim
48 words
A method as in claim 9, wherein said second magnetic field gradient pulse causes a magnetization wrap gradient in a different direction from that caused by said magnetic field gradient pulse and said pre-imaging sequence further comprises a third radio-frequency pulse after said second magnetic field gradient pulse.
Claim 13
Independent Claim
197 words
A method of detecting motion of a body portion of a patient using magnetic resonance imaging, comprising the steps of: inducing in the body portion a magnetization vector by applying to the body portion an external magnetic field; applying a pre-imaging pulse sequence to a body portion, said pre-imaging pulse sequence comprising a first radio-frequency pulse which produces transverse magnetization of the magnetization vector, a magnetic field gradient pulse which modulates the phase of transverse magnetization of the magnetization vector by providing a magnetic field gradient at the body portion and wrapping the phase of the transverse magnetization along the direction of the magnetic field gradient, and a second radio-frequency pulse which amplitude modulates said phase modulated transverse magnetization so as to produce amplitude modulated longitudinal magnetization of the magnetization vector, thereby producing a spatial modulation pattern of said amplitude modulated longitudinal magnetization; applying an imaging sequence to the body portion to make visible said spatial modulation pattern of amplitude modulated longitudinal magnetization; and detecting motion of said body portion during a time interval between application of said pre-imaging and imaging sequences by examining displacements of the spatial modulation pattern of interest occurring during said time interval.
Claim 14
Independent Claim
197 words
A method of detecting motion of a body portion of a patient using magnetic resonance imaging, comprising the steps of: inducing in the body portion a magnetization vector by applying to the body portion an external magnetic field; applying a pre-imaging pulse sequence to a body portion, said pre-imaging pulse sequence comprising a first radio-frequency pulse which produces transverse magnetization of the magnetization vector, a magnetic field gradient pulse which modulates the phase of transverse magnetization of the magnetization vector by providing a magnetic field gradient at the body portion and wrapping the phase of the transverse magnetization along the direction of the magnetic field gradient, and a second radio-frequency pulse which amplitude modulates said phase modulated transverse magnetization so as to produce amplitude modulated longitudinal magnetization of the magnetization vector, thereby producing a spatial modulation pattern of said amplitude modulated longitudinal magnetization; applying an imaging sequence to the body portion to make visible said spatial modulation pattern of amplitude modulated longitudinal magnetization; and detecting motion of said body portion during a time interval between application of said pre-imaging and imaging sequences by examining displacements of the spatial modulation pattern of interest occurring during said time interval.
Claim 15
Dependent Claim
15 words
A method as in claim 11, wherein said body portion is the patient's heart wall.
Claim 16
Dependent Claim
14 words
A method as in claim 11, wherein said body portion is the patient's blood.
Claim 17
Dependent Claim
15 words
A method as in claim 11, wherein said body portion is the patient's cerebrospinal fluid.
Claim 18
Independent Claim
111 words
A method of magnetic resonance imaging a heart wall of a patient for detecting motion of said heart wall, comprising the steps of: applying to the heart wall an external magnetic field so as to produce a resultant magnetization; applying a pre-imaging sequence to the heart wall so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation patterns of magnetization; applying a cardiac gated imaging sequence to the heart wall to make visible said spatial modulation pattern of magnetization; and providing an image representing the intensity of magnetic resonance signals having said spatial modulation pattern of magnetization which are emitted from the patient.
Claim 19
Independent Claim
111 words
A method of magnetic resonance imaging a heart wall of a patient for detecting motion of said heart wall, comprising the steps of: applying to the heart wall an external magnetic field so as to produce a resultant magnetization; applying a pre-imaging sequence to the heart wall so as to spatially modulate transverse and longitudinal components of the resultant magnetization, thereby producing a spatial modulation patterns of magnetization; applying a cardiac gated imaging sequence to the heart wall to make visible said spatial modulation pattern of magnetization; and providing an image representing the intensity of magnetic resonance signals having said spatial modulation pattern of magnetization which are emitted from the patient.
Claim 20
Dependent Claim
30 words
A method as in claim 15, wherein said pre-imaging sequence comprises a first radio-frequency pulse followed by a magnetic field gradient pulse which is followed by a second radio-frequency pulse.
Claim 21
Dependent Claim
36 words
A method as in claim 16, wherein said second radio-frequency pulse causes a magnetization change having a magnitude approximately equal to a magnitude of a magnetization change caused by said first at least one radio-frequency pulse.
Claim 22
Dependent Claim
23 words
A method as in claim 16, wherein said pre-imaging sequence further comprises a second magnetic field gradient pulse after said second radio-frequency pulse.
Claim 23
Dependent Claim
48 words
A method as in claim 18, wherein said second magnetic field gradient pulse causes a magnetization wrap gradient in a different direction from that caused by said magnetic field gradient pulse and said pre-imaging sequence further comprises a third ratio-frequency pulse after said second magnetic field gradient pulse.
References Cited (Backward Citations)
US4752734A
Cited
US4953554A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-10-07 | 1995-04-08 | 1995-10-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-10-07 | 1999-04-08 | 1999-10-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-10-07 | 2003-04-08 | 2003-10-08 | $7700.00 | Window Closed / Lapsed |