Patent US5049565A successfully refreshed from Google Patents.
US5049565A
Expired / Lapsed
US
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Microbial transformation process for preparing anti-hypertensive products
Assignee: Merck and Co Inc
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Filing: 1990-12-07
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Granted: 1991-09-17
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Expires: 2010-12-07
Abstract
Abstract Fermentation of the microorganism Streptomyces sp. (MA6750) ATTC No. 55042 in the presence of the Angiotensin II (A II) receptor antagonist ##STR1## yields three analogs, each having a shikimate sugar-like moiety attached to the tetrazole, which are also A II antagonists useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.
Inventors
- 👤 Shieh-Shung T. Chen
- 👤 Raymond F. White
- 👤 Byron H. Arison
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 03:47
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
11 words
A compound of structural formula (I) or (II) or (III): ##STR6##
Claim 2
Dependent Claim
11 words
A compound of structural formula (I) or (II) or (III): ##STR6##
Claim 3
Dependent Claim
21 words
An antihypertensive pharmaceutical composition comprising a non-toxic therapeutically effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier.
Claim 4
Dependent Claim
32 words
A method of treating hypertension or congestive heart failure comprising the administration of a non-toxic therapeutically effective amount of the compound of claim 1 to a subject in need of such treatment.
Claim 5
Dependent Claim
65 words
A process for the preparation of a compound represented by formula (I) or (II) or (III) ##STR7## comprising the steps of culturing a microorganism Streptomyces sp. (MA 6750) (ATCC No. 55042) in a nutrient medium containing assimilable sources of nitrogen and carbon and substrate compound (IV) ##STR8## under aerobic conditions until a substantial amount of the compound is produced and isolating the compound so produced.
Claim 6
Dependent Claim
65 words
A process for the preparation of a compound represented by formula (I) or (II) or (III) ##STR7## comprising the steps of culturing a microorganism Streptomyces sp. (MA 6750) (ATCC No. 55042) in a nutrient medium containing assimilable sources of nitrogen and carbon and substrate compound (IV) ##STR8## under aerobic conditions until a substantial amount of the compound is produced and isolating the compound so produced.
Claim 7
Dependent Claim
11 words
The process of claim 4 wherein the temperature is 26°-29° C.
Claim 8
Dependent Claim
11 words
The process of claim 5 wherein the temperature is 27° C.
References Cited (Backward Citations)
EP0399731A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-16 | 1995-03-18 | 1995-09-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-16 | 1999-03-18 | 1999-09-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-16 | 2003-03-18 | 2003-09-17 | $7700.00 | Window Closed / Lapsed |