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US5049403A
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Process for the preparation of surface modified solid substrates
Assignee: Carmeda AB
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Filing: 1989-10-12
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Granted: 1991-09-17
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Expires: 2009-10-12
Abstract
Abstract Method for surface modifying substrates characterized in absorbing on the surface of a solid substrate a polyamine of a high average molecular weight and cross-linking this with crotonaldehyde either simultaneously or by addition in separate steps to produce amino groups on the surface of the substrate, and optionally adsorbing one or several alternating layers of an anionic polysaccharide and of the said polyamine being cross-linked with crotonaldehyde, and optionally finally adsorbing the said polyamine, not cross-linked, to produce free primary amino groups by which chemical entities having a biological activity may be bound by covalent or ionic bonding.
Inventors
- 👤 Karl O. P. Larm
- 👤 Lars A. Adolfsson
- 👤 Kjell P. Olsson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:46
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; C; C08; C08G; C08G73/00; C08G73/02; C08G73/0206; C08J; C08J7/00; C08J7/04; C08J7/0427; C08L; C08L79/00; C08L79/02; C08J2479/00; C08L23/00; C08L25/00; C08L25/02; C08L25/04; C08L25/06; C08L27/00; C08L27/02; C08L27/04; C08L27/06; C08L27/12; C08L27/18; C08L75/00; C08L75/04; C08L83/00; Y; Y10; Y10T; Y10T428/00; Y10T428/31; Y10T428/315; Y10T428/31504; Y10T428/3154; Y10T428/31551; Y10T428/31652; Y10T428/31663; Y10T428/31678; Y10T428/31855
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
33 words
A method for the surface modification of a substrate which comprises adsorbing on the surface of a solid substrate a polyamine having a high average molecular weight and cross-linking the polyamine with crotonaldehyde.
Claim 2
Independent Claim
33 words
A method for the surface modification of a substrate which comprises adsorbing on the surface of a solid substrate a polyamine having a high average molecular weight and cross-linking the polyamine with crotonaldehyde.
Claim 3
Dependent Claim
30 words
A method according to claim 1 wherein the adsorption and cross-linking with the crotonaldehyde is achieved by applying to the substrate an aqueous solution containing the polyamine and the crotonaldehyde.
Claim 4
Dependent Claim
35 words
A method according to claim 1 wherein the polyamine is first adsorbed onto the surface of the substrate and the thus treated substrate is then contacted with a solution containing the crotonaldehyde to achieve cross-linking.
Claim 5
Dependent Claim
32 words
A method according to claim 1 wherein following cross-linking there is applied to the substrate a solution of an anionic polysaccharide to obtain at least one adsorbed layer of said anionic polysaccharide.
Claim 6
Dependent Claim
32 words
A method according to claim 4 wherein a plurality of adsorbed layers of anionic polysaccharide are formed, each of said layers alternating with an adsorbed layer of the polyamine cross-linked with crotonaldehyde.
Claim 7
Dependent Claim
35 words
A method according to claim 1 wherein there is adsorbed onto the treated surface of the substrate as a final step the polyamine which is not cross-linked in order to provide free primary amino groups.
Claim 8
Dependent Claim
36 words
A method according to claim 4 wherein there is subsequently adsorbed onto the treated surface of the substrate as a final step the polyamine which is not cross-linked in order to provide free primary amino groups.
Claim 9
Dependent Claim
15 words
A method according to claim 6 wherein the free primary amino groups are subsequently quaternized.
Claim 10
Dependent Claim
15 words
A method according to claim 7 wherein the free primary amino groups are subsequently quaternized.
Claim 11
Dependent Claim
17 words
A method according to claim 1 wherein the substrate is a metal, glass or a polymeric material.
Claim 12
Dependent Claim
14 words
A method according to claim 10 wherein the substrate is stainless steel or aluminum.
Claim 13
Dependent Claim
20 words
A method according to claim 10, wherein the substrate is selected from polyvinylchloride, polyurethane, silicon rubber, polytetrafluoroethylene, polystyrene and polyolefin.
Claim 14
Dependent Claim
12 words
A method according to claim 1 wherein the polysaccharide is dextran sulfate.
Claim 15
Dependent Claim
11 words
A method according to claim 1 wherein the polyamine is polyethylenimine.
References Cited (Backward Citations)
US4565740A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-16 | 1995-03-18 | 1995-09-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-16 | 1999-03-18 | 1999-09-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-16 | 2003-03-18 | 2003-09-17 | $7700.00 | Window Closed / Lapsed |