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US5049393A Expired / Lapsed US ⏱️ 0.0 years remaining

Anti-thrombogenic elastomer and objects and prostheses made therefrom

Assignee: Baylor College of Medicine
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Filing: 1988-06-30
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Granted: 1991-09-17
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Expires: 2008-06-30
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Abstract

Abstract Disclosed are anti-thrombogenic compositions, methods for their production and products made therefrom. The Anti-thrombogenic compositions comprise a powderized anti-thrombogenic material homogeneously present in a solidifiable matrix material. The anti-thrombogenic material is preferably carbon and more preferably graphite particles. The matrix material is a silicon polymer, a urethane polymer or an acrylic polymer.

Inventors

  • 👤 George P. Noon
  • 👤 Louis W. Feldman
  • 👤 Julia A. Peterson

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-02 07:05
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/443; A61L33/00; A61L33/02; A61L33/025

Claims Analysis

Total Claims: 34
Claim 1
Independent Claim 40 words
An antithrombogenic composition consisting essentially of a biocompatible miscible matrix material selected from the group consisting of a silicone polymer, an acrylic polymer and a urethane polymer, and powderized graphite distributed throughout said miscible material rendering said composition anti-thrombogenic throughout.
Claim 2
Dependent Claim 40 words
An antithrombogenic composition consisting essentially of a biocompatible miscible matrix material selected from the group consisting of a silicone polymer, an acrylic polymer and a urethane polymer, and powderized graphite distributed throughout said miscible material rendering said composition anti-thrombogenic throughout.
Claim 3
Dependent Claim 49 words
An antithrombogenic composition comprising a biocompatible miscible matrix material selected from the group consisting of a silicone polymer, an acrylic polymer and a urethane polymer, and powderized graphite particles ranging in size from about 3 to about 7 microns distributed throughout said miscible material rendering said composition anti-thrombogenic throughout.
Claim 4
Dependent Claim 49 words
An antithrombogenic composition comprising a biocompatible miscible matrix material selected from the group consisting of a silicone polymer, an acrylic polymer and a urethane polymer, and powderized graphite particles ranging in size from about 3 to about 7 microns distributed throughout said miscible material rendering said composition anti-thrombogenic throughout.
Claim 5
Dependent Claim 54 words
An anti-thrombogenic composition comprising, miscible solidifiable material, the miscible solidifiable material selected from the group consisting of a silicone polymer, a urethane polymer and an acrylic polymer, powderized graphite particles ranging in size between about 3 to about 7 microns, said powderized graphite homogeneously distributed throughout said miscible material rendering said composition anti-thrombogenic throughout.
Claim 6
Dependent Claim 54 words
An anti-thrombogenic composition comprising, miscible solidifiable material, the miscible solidifiable material selected from the group consisting of a silicone polymer, a urethane polymer and an acrylic polymer, powderized graphite particles ranging in size between about 3 to about 7 microns, said powderized graphite homogeneously distributed throughout said miscible material rendering said composition anti-thrombogenic throughout.
Claim 7
Dependent Claim 37 words
A process for preparing a homogeneous anti-thrombogenic composition consisting essentially of mixing a miscible material containing a polymer selected from the group consisting of a silicone polymer, an acrylic polymer and a urethane polymer, and powderized graphite.
Claim 8
Dependent Claim 37 words
A process for preparing a homogeneous anti-thrombogenic composition consisting essentially of mixing a miscible material containing a polymer selected from the group consisting of a silicone polymer, an acrylic polymer and a urethane polymer, and powderized graphite.
Claim 9
Dependent Claim 11 words
The process of claim 4 wherein the miscible material is solidifiable.
Claim 10
Dependent Claim 25 words
The process of claim 5 wherein the solidifiable material is selected from the group consisting of a silicone polymer, urethane polymer, and an acrylic polymer.
Claim 11
Dependent Claim 11 words
The process of claim 4 wherein the anti-thrombogenic material is carbon.
Claim 12
Dependent Claim 12 words
The process of claim 7 wherein the anti-thrombogenic material is graphite particles.
Claim 13
Dependent Claim 50 words
A process for preparing a homogeneous anti-thrombogenic composition comprising mixing a miscible material containing a polymer selected from the group consisting of a silicone polymer, an acrylic polymer and a urethane polymer, and powderized graphite wherein said graphite comprises particles ranging in size from about 3 to about 7 microns.
Claim 14
Dependent Claim 50 words
A process for preparing a homogeneous anti-thrombogenic composition comprising mixing a miscible material containing a polymer selected from the group consisting of a silicone polymer, an acrylic polymer and a urethane polymer, and powderized graphite wherein said graphite comprises particles ranging in size from about 3 to about 7 microns.
Claim 15
Dependent Claim 13 words
The process of claim 4, including the step of solidifying the resulting mixture.
Claim 16
Dependent Claim 13 words
The process of claim 6 including the step of curing the solidifiable material.
Claim 17
Dependent Claim 145 words
A surgical process for connecting an artificial tubular graft to a natural tubular member, the process comprising, inserting the artificial tubular graft through an opening in a cylindrical hollow tie ring so that part of the artificial graft extends beyond the opening, folding back the extending part of the artificial graft over an outwardly extending front edge of the tie ring into a first recess between the front edge and a flange extending exteriorly from the middle of the tie ring, securing the folded back portion of the artificial graft in the first recess, introducing the artificial-graft-tie-ring structure into the natural tubular member so that the natural tubular member covers the first recess and extends beyond it into a second recess formed between the flange and an upwardly extending rear edge of the tie ring, and securing the natural tubular member in the second recess.
Claim 18
Dependent Claim 145 words
A surgical process for connecting an artificial tubular graft to a natural tubular member, the process comprising, inserting the artificial tubular graft through an opening in a cylindrical hollow tie ring so that part of the artificial graft extends beyond the opening, folding back the extending part of the artificial graft over an outwardly extending front edge of the tie ring into a first recess between the front edge and a flange extending exteriorly from the middle of the tie ring, securing the folded back portion of the artificial graft in the first recess, introducing the artificial-graft-tie-ring structure into the natural tubular member so that the natural tubular member covers the first recess and extends beyond it into a second recess formed between the flange and an upwardly extending rear edge of the tie ring, and securing the natural tubular member in the second recess.
Claim 19
Dependent Claim 23 words
The process of claim 12 wherein the artificial tubular graft is an arterial graft and the natural tubular member is a bodily artery.
Claim 20
Dependent Claim 17 words
The process of claim 12 wherein the arterial graft is made from the composition of claim 1.
Claim 21
Dependent Claim 17 words
The process of claim 12 wherein the arterial graft is made from the composition of claim 3.
Claim 22
Dependent Claim 21 words
The process of claim 12 wherein a tied suture is used to secure the portions in the first and second recesses.
Claim 23
Dependent Claim 26 words
The process of claim 12 wherein a suture with knots spaced along its length is used to tie the natural tubular member in the second recess.
Claim 24
Dependent Claim 44 words
A tie ring for connecting a tubular graft to a natural tubular member, the tie ring comprising a hollow cylindrical body member having outwardly extending edges formed integrally at each end thereof and an outwardly extending flange formed integrally thereof between the two edges.
Claim 25
Dependent Claim 44 words
A tie ring for connecting a tubular graft to a natural tubular member, the tie ring comprising a hollow cylindrical body member having outwardly extending edges formed integrally at each end thereof and an outwardly extending flange formed integrally thereof between the two edges.
Claim 26
Dependent Claim 13 words
The tie ring of claim 18 formed of the composition of claim 1.
Claim 27
Dependent Claim 13 words
The tie ring of claim 18 formed of the composition of claim 3.
Claim 28
Dependent Claim 36 words
An anti-thrombogenic composition comprising, a homogeneous mixture of a miscible solidifiable material selected from the group consisting of silicone, urethane and acrylic, and powderized graphite particles ranging in size from about 3 to about 7 microns.
Claim 29
Dependent Claim 36 words
An anti-thrombogenic composition comprising, a homogeneous mixture of a miscible solidifiable material selected from the group consisting of silicone, urethane and acrylic, and powderized graphite particles ranging in size from about 3 to about 7 microns.
Claim 30
Dependent Claim 30 words
The composition of claim 1 wherein said solidifiable material comprises at least two materials selected from the group consisting of a silicone polymer, a urethane polymer and an acrylic polymer.
Claim 31
Dependent Claim 18 words
An object made from the composition of any one of claims 1, 2, 3, 4-11, 21 or 22.
Claim 32
Dependent Claim 12 words
The object of claim 23 wherein said object is a prosthetic device.
Claim 33
Dependent Claim 13 words
The object of claim 23 wherein said object is a tubular arterial graft.
Claim 34
Dependent Claim 11 words
The object of claim 23 wherein said object is a bladder.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1994-09-16 1995-03-18 1995-09-17 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1998-09-16 1999-03-18 1999-09-17 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2002-09-16 2003-03-18 2003-09-17 $7700.00 Window Closed / Lapsed

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