US5049322A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the preparaton of dispersible colloidal systems of a substance in the form of nanocapsules
Assignee: Centre National de la Recherche Scientifique
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Filing: 1987-12-31
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Granted: 1991-09-17
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Expires: 2007-12-31
Abstract
Abstract The process according to the invention comprises: (1) the preparation of a liquid phase consisting essentially of a solution of a substance A in a solvent or in a mixture of solvents, and containing the substance B in solution or as a dispersion, (2) the preparation of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substances A and B, and supplemented with one or more surfactants, the solvent or mixture of solvents of the first phase being miscible in all proportions with the non-solvent or mixture of non-solvents of the second phase, (3) the addition of the first phase to the second phase with moderate agitation so as to produce a colloidal suspension of nanocapsules, the wall of which is constituted by the substance A and the core by the substance B, (4) if desired, the removal of all or part of the solvent or the mixture of solvents and of the non-solvent or the mixture of non-solvents so as to produce a colloidal suspension of nanocapsules of the desired concentration or to produce a powder of nanocapsules following the addition of stabilizing substances.
Inventors
- 👤 Jean-Philippe Devissaguet
- 👤 Hatem Fessi
- 👤 Francis Puisieux
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 09:56
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/51; A61K9/5107; A61K9/513; A61K9/5138; A61K9/5146; A61K9/5153; A61K9/5192; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
171 words
A process for the preparation of dispersible colloidal systems in the form of spherical particles of the vesicular type and of a size less than 500 nm (nanocapsules), the wall of which is constituted by a substance A having film-forming properties and the core by a liquid substance B capable of being encapsulated by the substance A, comprising: combining (1) a first liquid phase consisting essentially of a solution of the substances A and B in a solvent for the substances A and B or in a mixture of solvents for the substances A and B, and (2) a greater amount of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substances A and B and including one or more surfactants, the solvent or the mixture of solvents of the first phase being miscible in all proportions with the non-solvent or mixture of non-solvents of the second phase, comprising a core of said liquid substance B surrounded by a layer of said substance A.
Claim 2
Dependent Claim
171 words
A process for the preparation of dispersible colloidal systems in the form of spherical particles of the vesicular type and of a size less than 500 nm (nanocapsules), the wall of which is constituted by a substance A having film-forming properties and the core by a liquid substance B capable of being encapsulated by the substance A, comprising: combining (1) a first liquid phase consisting essentially of a solution of the substances A and B in a solvent for the substances A and B or in a mixture of solvents for the substances A and B, and (2) a greater amount of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substances A and B and including one or more surfactants, the solvent or the mixture of solvents of the first phase being miscible in all proportions with the non-solvent or mixture of non-solvents of the second phase, comprising a core of said liquid substance B surrounded by a layer of said substance A.
Claim 3
Dependent Claim
21 words
A process according to claim 1, wherein said combining step comprises adding the first liquid phase to the second liquid phase.
Claim 4
Dependent Claim
23 words
A process according to claim 1, wherein surfactant(s) are present in a proportion of 0.1 to 10% by weight of the colloidal suspension.
Claim 5
Dependent Claim
20 words
A process according to claim 3, wherein the surfactant(s) are present in a proportion of 0.2 to 2% by weight.
Claim 6
Dependent Claim
12 words
A process according to claim 1, wherein substance A is a polymer.
Claim 7
Dependent Claim
24 words
A process according to claim 5, wherein said polymer is present in said solvent in a concentration of between 0.1 and 10% by weight.
Claim 8
Dependent Claim
21 words
A process according to claim 6, wherein said polymer is present in a concentration of between 0.2 and 2% by weight.
Claim 9
Dependent Claim
14 words
A process according to claim 1, wherein substance B is a biologically active substance.
Claim 10
Dependent Claim
12 words
A process according to claim 1, wherein substance B is an oil.
Claim 11
Dependent Claim
19 words
A process according to claim 8, wherein substance B is a biologically active substance in solution in an oil.
Claim 12
Dependent Claim
17 words
A process according to claim 13, further comprising removing by lyophilization all of the solvents and non-solvents.
Claim 13
Dependent Claim
19 words
A process according to claim 1, wherein said nanocapsules are of a size of about 150 to 450 nm.
Claim 14
Dependent Claim
39 words
A process according to claim 1, further comprising removing at least a portion of the solvent or mixture of solvents and non-solvent or mixture of non-solvents to produce a concentrated colloidal suspension of nanocapsules or a powder of nanocapsules.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-16 | 1995-03-18 | 1995-09-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-16 | 1999-03-18 | 1999-09-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-16 | 2003-03-18 | 2003-09-17 | $7700.00 | Window Closed / Lapsed |