US5047523A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nucleic acid probe for detection of neisseria gonorrhoea
Assignee: Ortho Clinical Diagnostics Inc
•
Filing: 1988-08-02
•
Granted: 1991-09-10
•
Expires: 2008-08-02
Abstract
Abstract The invention discloses nucleic acid probes specific for Neisseria gonorrhoea useful in diagnostic methods to detect the presence of N. gonorrhoea in biological specimens.
Inventors
- 👤 Derek Woods
- 👤 M. Jane Madonna
- 👤 Linda S. Mulcahy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 21:21
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6876; C12Q1/6888; C12Q1/689; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/871
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
35 words
A nucleic acid probe, consisting essentially of at least one nucleotide sequence having a length of from 30 to 600 bases selected from the group consisting of 5'...AGCTTTTTGGCGCTGCGTCCGGCTAACTGATATCTGCATGGAGGCAACCGGC AGTTATTATGAAGAAGTTGCCGACTACTTCGCGCAGTATTACAGCGTTTACGT AGTGAACCCGCTGAAAATAAGCAAGTATGCAGAAAGCAGGTTCAAGCGAACCAAA ACAGACAAACAGGATGCAAAAGCTGATAGCGCTCAGTATTGCCGGTCGCGGAAAGA AAGCGAGCTTGTAAAGAGGCAGAAGCTACGGACACGAGCAATACAGGCTTTTACGG ATGACGCCAGCTAACGCGTCAATCAAAGCGTAGCGCTGCATGAAACGTCTACAGGC TAAGATAG...3' and
Claim 2
Dependent Claim
35 words
A nucleic acid probe, consisting essentially of at least one nucleotide sequence having a length of from 30 to 600 bases selected from the group consisting of 5'...AGCTTTTTGGCGCTGCGTCCGGCTAACTGATATCTGCATGGAGGCAACCGGC AGTTATTATGAAGAAGTTGCCGACTACTTCGCGCAGTATTACAGCGTTTACGT AGTGAACCCGCTGAAAATAAGCAAGTATGCAGAAAGCAGGTTCAAGCGAACCAAA ACAGACAAACAGGATGCAAAAGCTGATAGCGCTCAGTATTGCCGGTCGCGGAAAGA AAGCGAGCTTGTAAAGAGGCAGAAGCTACGGACACGAGCAATACAGGCTTTTACGG ATGACGCCAGCTAACGCGTCAATCAAAGCGTAGCGCTGCATGAAACGTCTACAGGC TAAGATAG...3' and
Claim 3
Dependent Claim
19 words
' . .ATTCCCGGGGATCGTAATCTCCGCCTTTCTTATGTACGTGATACGCAATAAC GGCGAGTTTACGCATCAATGCTGCGATGATGACTTTTTTAGGCTTCTTCTTTT CTTCCAGTCTTGCTATGAAGTCGGGAAATGCCCTTATGCGGTATGCGACATGGCCGG CATAAACAAGACGGCGCGTAATTTCCTGTTGCCAAACTTGGTCAGTTTGCCTTTTCC CCTTACGCTTGTCCCGGATTGACTTTTTGTTGCGGGCTTAAGCTGCGAACGCTGCAA ATTTGTTTGATGTTTCAAATTTCGAAGATGTTAGATGATGAAACACTAGCTGCGTC ATTCTGCTATGCGGTATGTTCAGAGCTCAGCTCTGACGTAGCTTCG...3'; said probe capable of hybridizing with Neisseria gonorrhoea chromosomal DNA.
Claim 4
Dependent Claim
19 words
' . .ATTCCCGGGGATCGTAATCTCCGCCTTTCTTATGTACGTGATACGCAATAAC GGCGAGTTTACGCATCAATGCTGCGATGATGACTTTTTTAGGCTTCTTCTTTT CTTCCAGTCTTGCTATGAAGTCGGGAAATGCCCTTATGCGGTATGCGACATGGCCGG CATAAACAAGACGGCGCGTAATTTCCTGTTGCCAAACTTGGTCAGTTTGCCTTTTCC CCTTACGCTTGTCCCGGATTGACTTTTTGTTGCGGGCTTAAGCTGCGAACGCTGCAA ATTTGTTTGATGTTTCAAATTTCGAAGATGTTAGATGATGAAACACTAGCTGCGTC ATTCTGCTATGCGGTATGTTCAGAGCTCAGCTCTGACGTAGCTTCG...3'; said probe capable of hybridizing with Neisseria gonorrhoea chromosomal DNA.
Claim 5
Dependent Claim
31 words
The nucleic acid probe of claim 1 consisting essentially of a nucleic acid sequence substantially complementary to said nucleotide sequence of claim 12 and capable of hybridization with said nucleotide sequence.
Claim 6
Dependent Claim
31 words
A nucleic acid probe consisting essentially of at least one nucleotide sequence selected from the group consisting of ##STR6## said nucleic acid probe capable of hybridizing to Neisseria gonorrhoea chromosomal DNA.
Claim 7
Dependent Claim
31 words
A nucleic acid probe consisting essentially of at least one nucleotide sequence selected from the group consisting of ##STR6## said nucleic acid probe capable of hybridizing to Neisseria gonorrhoea chromosomal DNA.
Claim 8
Dependent Claim
22 words
The nucleic acid probe of claim 3 consisting essentially of at least one nucleotide sequence selected from the group consisting of ##STR7##
Claim 9
Dependent Claim
30 words
The nucleic acid probe of claim 4 consisting essentially of a nucleotide sequence substantially complementary to said nucleotide sequence of claim 17 and capable of hybridization with said nucleotide sequence.
Claim 10
Dependent Claim
38 words
The nucleic acid probe of claim 4 consisting essentially of a subset, derivative, subclone, or mutation of all or a part of said at least one nucleotide sequence; said probe capable of hybridizing to Neisseria gonorrhoea chromosomal DNA.
Claim 11
Dependent Claim
19 words
The nucleic acid probe of claim 1 further comprising a 3' tail sequence having a detectable label bound thereon.
Claim 12
Dependent Claim
15 words
The nucleic acid probe of claim 7 wherein said tail sequence comprises a nucleotide sequence.
Claim 13
Dependent Claim
15 words
The nucleic acid probe of claim 8 wherein said nucleotide sequence comprises adenosine and uridine.
Claim 14
Dependent Claim
16 words
The nucleic acid probe of claim 9 wherein said uridine has a detectable label bound thereon.
Claim 15
Dependent Claim
13 words
The nucleic acid probe of claim 10 wherein said detectable label is biotin.
Claim 16
Dependent Claim
18 words
The nucleic acid probe of claim 3 further comprising a tail sequence having a detectable label bound thereon.
Claim 17
Dependent Claim
15 words
The nucleic acid probe of claim 12 wherein said tail sequence comprises a nucleotide sequence.
Claim 18
Dependent Claim
15 words
The nucleic acid probe of claim 13 wherein said nucleotide sequence comprises adenosine and uridine.
Claim 19
Dependent Claim
16 words
The nucleic acid probe of claim 14 wherein said uridine has a detectable label bound thereon.
Claim 20
Dependent Claim
13 words
The nucleic acid probe of claim 15 wherein said detectable label is biotin.
References Cited (Backward Citations)
US4358525A
Cited
EP0079139A1
Cited
EP0286898A2
Cited
EP0097373A2
Cited
EP0285057B1
Cited
EP0117440A1
Cited
WO1984003285A1
Cited
EP0122614A2
Cited
EP0123300A2
Cited
EP0154788A2
Cited
WO1985004674A1
Cited
EP0194545A2
Cited
EP0212546A2
Cited
EP0221308A1
Cited
EP0219695A1
Cited
EP0231495B1
Cited
EP0237737A2
Cited
EP0235726A2
Cited
WO1988001302A1
Cited
US4794082A
Cited
EP0292128A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-09 | 1995-03-11 | 1995-09-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-09 | 1999-03-11 | 1999-09-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-09 | 2003-03-11 | 2003-09-10 | $7700.00 | Window Closed / Lapsed |