Patent US5047244A successfully refreshed from Google Patents.
US5047244A
Expired / Lapsed
US
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Mucoadhesive carrier for delivery of therapeutical agent
Assignee: Actavis Laboratories UT Inc
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Filing: 1988-06-03
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Granted: 1991-09-10
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Expires: 2008-06-03
Abstract
Abstract A mucoadhesive carried suitable for a therapeutic agent is disclosed. This carrier allows controlled release of the therapeutic agent via mucosal tissue. The mucoadhesive carrier comprises a Monolithic polymer matrix that is anhydrous but hydratable, and amorphous fumed silica. The silica enhances the mucoadhesive properties of the carrier. An optional water-insoluble barrier film or layer can be secured to the polymer matrix to provide a non-adhering face.
Inventors
- 👤 Dilip R. Sanvordeker
- 👤 Sau-Hung S. Leung
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 15:30
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/006; A61F; A61F13/00; A61F13/02; A61F13/023; A61F13/0246; A61M; A61M31/00; A61M31/002; A61F2013/00361; A61F2013/00655; A61F2013/00714; A61F2013/00727; A61F2013/00748; A61F2013/00761; A61F2013/00787; A61F2013/00902; A61F2013/00906
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being dehydroepiandrosterone, said polymer being polyethylene glycol having a number average molecular weight of about 4,000, and the weight ratio of dehydroepiandrosterone to said polyethylene glycol being about 1:4, respectively.
Claim 2
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being dehydroepiandrosterone, said polymer being polyethylene glycol having a number average molecular weight of about 4,000, and the weight ratio of dehydroepiandrosterone to said polyethylene glycol being about 1:4, respectively.
Claim 3
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being nifedipine, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of nifedipine to said polyethylene glycol being about 1:2, respectively.
Claim 4
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being nifedipine, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of nifedipine to said polyethylene glycol being about 1:2, respectively.
Claim 5
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being piroxicam, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of piroxicam to said polyethylene glycol being about 1:2, respectively.
Claim 6
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being piroxicam, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of piroxicam to said polyethylene glycol being about 1:2, respectively.
Claim 7
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being albuterol, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of albuterol to said polyethylene glycol being about 1:2, respectively.
Claim 8
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being albuterol, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of albuterol to said polyethylene glycol being about 1:2, respectively.
Claim 9
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being dehydroepiandrosterone, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of dehydroepiandrosterone to said polyethylene glycol being about 1:2, respectively.
Claim 10
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being dehydroepiandrosterone, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of dehydroepiandrosterone to said polyethylene glycol being about 1:2, respectively.
Claim 11
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being phenylpropanolamine, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of phenylpropanolamine to said polyethylene glycol being about 1:2, respectively.
Claim 12
Dependent Claim
76 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being phenylpropanolamine, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of phenylpropanolamine to said polyethylene glycol being about 1:2, respectively.
Claim 13
Dependent Claim
78 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being 17 β-estradiol, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of 17 β-estradiol to said polyethylene glycol being about 1:2, respectively.
Claim 14
Dependent Claim
78 words
A therapeutic dosage form comprising an anhydrous but hydratable monolithic polymer matrix that contains amorphous fumed silica as well as a therapeutic agent and defines a mucoadhesive face, and a water-insoluble barrier layer secured to said polymer matrix and defining a non-adhesive face; said therapeutic agent being 17 β-estradiol, said polymer being polyethylene glycol having a number average molecular weight of about 8,000, and the weight ratio of 17 β-estradiol to said polyethylene glycol being about 1:2, respectively.
Claim 15
Dependent Claim
27 words
The therapeutic dosage form in accordance with claims 1, 2, 3, 4, 5, 6, or 7 and provided with a retrieving element embedded in said polymer matrix.
Claim 16
Dependent Claim
17 words
The therapeutic dosage form in accordance with claim 8 wherein the retrieving element is a string segment.
Claim 17
Dependent Claim
17 words
The therapeutic dosage form in accordance with claim 8 wherein the retrieving element is a planar member.
Claim 18
Dependent Claim
15 words
The therapeutic dosage form in accordance with claim 10 wherein said planar member is perforated.
References Cited (Backward Citations)
US3551556A
Cited
US3911099A
Cited
JPS5724970A
Cited
US4704119A
Cited
US4740365A
Cited
JPS6115829A
Cited
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