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US5043323A
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Complex compounds of bioflavonoids with phospholipids, their preparation and use, and pharmaceutical and cosmetic compositions containing them
Assignee: Indena SpA
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Filing: 1988-01-12
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Granted: 1991-08-27
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Expires: 2008-01-12
Abstract
Abstract Complex compounds of flavonoids with phospholipids, characterized by high lipophilia and improved bio-availability and therapeutic properties as compared with free, not complexed flavonoids. The complex compounds of the invention are suitable for use as the active principle in pharmaceutical and cosmetic compositions.
Inventors
- 👤 Ezio Bombardelli
- 👤 Gian F. Patri
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:04
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/10; C07F9/106; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/54; A61K47/543; A61K47/544; A61K8/00; A61K8/18; A61K8/30; A61K8/55; A61K8/553; A61K8/60; A61K8/602; A61K8/96; A61K8/97; A61K8/9771; A61K8/9783; A61K8/9789; A61P; A61P29/00; A61P3/00; A61P9/00; A61P9/08; A61Q; A61Q19/00; C07H; C07H17/00; C07H17/04; C07H17/06; C07H17/065; C07H17/07
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
106 words
A complex of a flavonoid with a phospholipid wherein the flavonoid is a member selected from the group consisting of quercetin, kaempferol, quercetin-3-ramnoglucoside, quercetin-3-ramnoside, quercetin-3-glucoside, hyperoside, (+) apigenin, apigenin-7-glucoside, luteolin, luteolin-glucoside ramnoglucoside, 5,7,3',4'-pentahydroxy-flavone-3D-alfa-rhamnopyranosyl-4-D-beta-O-(6"-transcoumaroyl-)glucopyranoside, 3,4,5,4'-tetrahydroxy-flavone-3-D-alfa-rhamnopyranosyl-4-D-beta-O-(6"-trans-coumaroyl-)glucopyranoside, Ginkgonetine, Isoginkgonetine, Sciedopitasine, rutine and Bilobetine, and the phospholipid is a member selected from the group consisting of soy lecithins, egg lecithin phospholipids from bovine or swine brain or dermis, phosphatidyl choline, phosphatidyl serine, phosphatidyl ethanolamine in which the acyl groups are the same or different and are derived from palmitic, stearic, oleic, linoleic, linolenic acid, and wherein the phospholipid to flavonoid ratio is in the molar range from 0.5 to 2M.
Claim 2
Dependent Claim
106 words
A complex of a flavonoid with a phospholipid wherein the flavonoid is a member selected from the group consisting of quercetin, kaempferol, quercetin-3-ramnoglucoside, quercetin-3-ramnoside, quercetin-3-glucoside, hyperoside, (+) apigenin, apigenin-7-glucoside, luteolin, luteolin-glucoside ramnoglucoside, 5,7,3',4'-pentahydroxy-flavone-3D-alfa-rhamnopyranosyl-4-D-beta-O-(6"-transcoumaroyl-)glucopyranoside, 3,4,5,4'-tetrahydroxy-flavone-3-D-alfa-rhamnopyranosyl-4-D-beta-O-(6"-trans-coumaroyl-)glucopyranoside, Ginkgonetine, Isoginkgonetine, Sciedopitasine, rutine and Bilobetine, and the phospholipid is a member selected from the group consisting of soy lecithins, egg lecithin phospholipids from bovine or swine brain or dermis, phosphatidyl choline, phosphatidyl serine, phosphatidyl ethanolamine in which the acyl groups are the same or different and are derived from palmitic, stearic, oleic, linoleic, linolenic acid, and wherein the phospholipid to flavonoid ratio is in the molar range from 0.5 to 2M.
Claim 3
Dependent Claim
13 words
The complex according to claim 1 which is the quercetin/di-stearoyl phosphatidylcholine equimolecular complex.
Claim 4
Dependent Claim
13 words
The complex according to claim 1 which is the quercetin-3-galactoside/soy phosphatidylcholine equimolecular complex.
Claim 5
Dependent Claim
12 words
The complex according to claim 1 which is the quercetin-3-rhamnoglycoside/soy hosphatidylcholine complex.
Claim 6
Dependent Claim
11 words
The complex according to claim 1 which is the kaempferol-3-glycoside/soy phosphatidylcholine.
Claim 7
Dependent Claim
12 words
The complex according to claim 1 which is the vitexine-2"-rhamnoside-2"-acetate/soy phosphatidylcholine complex.
Claim 8
Dependent Claim
14 words
The complex according to claim 1 which is the Ginkgo biloba extract/soy phosphatidylcholine complex.
Claim 9
Dependent Claim
12 words
The complex according to claim 1 which is the apigenin/soy phosphatidylethanolamine complex.
Claim 10
Dependent Claim
10 words
The complex according to claim 1 which is apigenin/distearoylphosphatidylcholine complex.
Claim 11
Dependent Claim
11 words
The complex according to claim 1 which is luteolin-7-glycoside/soy phosphatidylcholine complex.
Claim 12
Dependent Claim
11 words
The complex according to claim 1 which is diosmin/soy phosphatidylcholine complex.
Claim 13
Dependent Claim
15 words
The complex according to claim 1 which is Gingko biloba depurated extract/total soy phospholipids complex.
Claim 14
Dependent Claim
11 words
The complex according to claim 1 which is Hawthorn/soy phosphatidylcholine complex.
Claim 15
Dependent Claim
39 words
A cosmetic composition for topical application containing 0.1-10% by weight as the active principle or a complex according to claim 13 in the form of a solution, powder, cream, gel, or as an aqueous microdispersion, with pharmaceutically acceptable carriers.
Claim 16
Dependent Claim
19 words
The composition according to claim 14 wherein said active principle is the Gingko biloba depurated extract/total soy phospholipids complex.
Claim 17
Dependent Claim
14 words
The composition according to claim 14 wherein the active principle is luteolin-7-glycoside/soy phosphatidylcholine complex.
Claim 18
Dependent Claim
14 words
The composition according to claim 14 wherein the active principle is luteolin-7-glycoside/soy phosphatidylcroline complex.
Claim 19
Dependent Claim
18 words
The composition according to claim 14 wherein the active principle is a phospholipid complex from luteolin or rutin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-08-26 | 1995-02-25 | 1995-08-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-26 | 1999-02-25 | 1999-08-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-26 | 2003-02-25 | 2003-08-27 | $7700.00 | Window Closed / Lapsed |