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US5039705A
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Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
Assignee: United States Department of Health and Human Services
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Filing: 1989-09-15
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Granted: 1991-08-13
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Expires: 2009-09-15
Abstract
Abstract This invention concerns anti-hypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: <IMAGE> I wherein R1 and R2 are independently chosen from straight chain and branched chain C1-C12 alkyl groups and benzyl, with the proviso that no branch occur on the alpha carbon atom of the alkyl groups; or R1 and R2 together with the nitrogen atom they are bonded to form a pyrrolidino, piperidino, piperazino or morpholino group, M+is a pharmaceutically acceptable cation, wherein X is the valence of the cation.
Inventors
- 👤 Larry K. Keefer
- 👤 David A. Wink
- 👤 Tambra M. Dunams
- 👤 Joseph A. Hrabie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 12:03
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/22; C07D295/28; C07D295/30; A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/33; A61K31/395; A61K31/40; A61K31/435; A61K31/44; A61K31/445; A61K31/495; A61K31/535; A61P; A61P35/00; A61P9/00; A61P9/12; C07C; C07C291/00; C07C291/02; C07C291/08; C07C307/00; C07C307/02
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
84 words
A sterile pharmaceutical composition useful in the treatment of hypertension comprising: an effective amount of a compound of the formula ##STR5## wherein R 1 and R 2 are independently selected from the group consisting of a straight chain or branched chain C 1 -C 12 alkyl group and a benzyl group, with the proviso that no branch occur on the alpha carbon atom, M +X is a pharmaceutically acceptable cation, wherein x is the valence of the cation; and a pharmaceutically acceptable carrier therefor.
Claim 2
Dependent Claim
84 words
A sterile pharmaceutical composition useful in the treatment of hypertension comprising: an effective amount of a compound of the formula ##STR5## wherein R 1 and R 2 are independently selected from the group consisting of a straight chain or branched chain C 1 -C 12 alkyl group and a benzyl group, with the proviso that no branch occur on the alpha carbon atom, M +X is a pharmaceutically acceptable cation, wherein x is the valence of the cation; and a pharmaceutically acceptable carrier therefor.
Claim 3
Dependent Claim
11 words
The composition of claim 1 in a form suitable for injection.
Claim 4
Dependent Claim
25 words
The composition of claim 2 wherein R 1 and R 2 are independently selected from the group consisting of C 2 -C 6 alkyl groups.
Claim 5
Dependent Claim
64 words
The composition of claim 3 wherein M +X is selected from the group consisting of group I, group II ions and NR 3 R 4 R 5 R 6 + , wherein R 3 , R 4 , R 5 and R 6 are independently selected from the group consisting of H, C 1 -C 12 alkyl, C 3 -C 7 cycloalkyl and benzy.
Claim 6
Dependent Claim
13 words
The composition of claim 4 wherein R 1 and R 2 are ethyl.
Claim 7
Dependent Claim
28 words
The composition of claim 5 wherein M +X is Na + , K + , Ca +2 or N(C 2 H 5 ) 2 H 2 + .
Claim 8
Dependent Claim
31 words
The composition of claim 2, 3, 4, 5 or 6 wherein the pharmaceutically acceptable carrier is selected from the group consisting of sterile water, phosphate buffered saline and aqueous glucose solutions.
Claim 9
Dependent Claim
17 words
The pharmaceutical composition of claim 1, wherein said composition is a sterile composition suitable for intravenous injection.
Claim 10
Dependent Claim
13 words
The pharmaceutical composition of claim 8, wherein said composition further comprises an antioxidant.
Claim 11
Independent Claim
87 words
A method of treating hypertension in mammals which comprises administering to a mammal, in need thereof, a blood pressure lowering effective amount of a compound of the formula: ##STR6## wherein R 1 and R 2 are independently selected from the group consisting of a straight chain or branched chain C 1 -C 12 alkyl group and a benzyl group, with the proviso that no branch occur on the alpha carbon atom; and M +X is a pharmaceutically acceptable cation, wherein x is the valence of the cation.
Claim 12
Independent Claim
87 words
A method of treating hypertension in mammals which comprises administering to a mammal, in need thereof, a blood pressure lowering effective amount of a compound of the formula: ##STR6## wherein R 1 and R 2 are independently selected from the group consisting of a straight chain or branched chain C 1 -C 12 alkyl group and a benzyl group, with the proviso that no branch occur on the alpha carbon atom; and M +X is a pharmaceutically acceptable cation, wherein x is the valence of the cation.
Claim 13
Dependent Claim
21 words
The method of claim 16 wherein R 1 and R 2 are independently selected from C 2 -C 6 alkyl groups.
Claim 14
Dependent Claim
61 words
The method of claim 11 wherein M +X is selected from the group consisting of group I, group II ions and NR 3 R 4 R 5 R 6 + , wherein R 3 , R 4 , R 5 and R 6 are independently selected from H, C 1 -C 12 alkyl groups, C 3 -C 7 cycloalkyl or benzyl.
Claim 15
Dependent Claim
13 words
The method of claim 12 wherein R 1 and R 2 are ethyl.
Claim 16
Dependent Claim
28 words
The method of claim 13 wherein M +X is NA + , K + , Ca +2 or N(C 2 H 5 ) 2 H 2 + .
References Cited (Backward Citations)
US3153094A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-08-12 | 1995-02-11 | 1995-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-12 | 1999-02-11 | 1999-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-12 | 2003-02-11 | 2003-08-13 | $7700.00 | Window Closed / Lapsed |