Patent US5039326A successfully refreshed from Google Patents.
US5039326A
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US
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Composition and method for radiation synovectomy of arthritic joints
Assignee: University of Missouri–St. Louis
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Filing: 1989-09-15
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Granted: 1991-08-13
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Expires: 2009-09-15
Abstract
Abstract A method for preparing nonradioactive microspheres adapted for radiation synovectomy of arthritic joints in a mammal involves forming the microspheres by doping a biodegradable glass material which may be lithium or potassium silicate, lithium or potassium aluminosilicate, lithium or potassium aluminoborate, lithium or potassium germanate or lithium or potassium aluminogermanate with an isotope which may be samarium, holmium, erbium, dysprosium, rhemium or yttrium so that the isotope is chemcially dissolved in and distributed uniformly throughout the glass material. The doped glass material is then treated with an acid wash to produce a thin layer on the surface thereof and heat treated to improve the chemical durability of the glass material by rendering the solubility of the layer lower than that of the underlying glass material.
Inventors
- 👤 Delbert E. Day
- 👤 Gary J. Ehrhardt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:37
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1258; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1611; A61K2121/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
173 words
A method for preparing nonradioactive microspheres adapted for radiation synovectomy of arthritic joints in a mammal comprising forming said microspheres by doping microspheres formed of a biodegradable glass material selected from the group consisting of lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germanate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium aluminoborate, potassium germanate and potassium aluminogermanate with an isotope selected from the group consisting of samarium, holmium, erbium, dysprosium, rhenium and yttrium so that said isotope is chemically dissolved in and distributed substantially uniformly throughout said microspheres material and which isotope, upon being subjected to an effective amount of neutron irradiation, will produce a beta radiation emitting radioisotope selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 and yttrium-90, treating said doped glass material with an acid wash to produce a thin layer on the surface of the glass material and heat treating the glass material to improve the chemical durability of the glass material by rendering the solubility of said layer lower than that of the underlying glass material.
Claim 2
Independent Claim
173 words
A method for preparing nonradioactive microspheres adapted for radiation synovectomy of arthritic joints in a mammal comprising forming said microspheres by doping microspheres formed of a biodegradable glass material selected from the group consisting of lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germanate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium aluminoborate, potassium germanate and potassium aluminogermanate with an isotope selected from the group consisting of samarium, holmium, erbium, dysprosium, rhenium and yttrium so that said isotope is chemically dissolved in and distributed substantially uniformly throughout said microspheres material and which isotope, upon being subjected to an effective amount of neutron irradiation, will produce a beta radiation emitting radioisotope selected from the group consisting of samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 and yttrium-90, treating said doped glass material with an acid wash to produce a thin layer on the surface of the glass material and heat treating the glass material to improve the chemical durability of the glass material by rendering the solubility of said layer lower than that of the underlying glass material.
Claim 3
Dependent Claim
23 words
A method as set forth in claim 1 wherein said heat treating step is carried out in the presence of SO 2 gas.
Claim 4
Dependent Claim
26 words
A method as set forth in claim 1 wherein said acid wash is selected from the group consisting of hydrochloric acid, sulfuric acid and nitric acid.
Claim 5
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium silicate and said radioisotope is samarium-153.
Claim 6
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium aluminosilicate and said radioisotope is samarium-153.
Claim 7
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium aluminoborate and said radiosotope is samarium-153.
Claim 8
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium silicate and said radioisotope is holmium-166.
Claim 9
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium aluminosilicate and said radioisotope is holmium-166.
Claim 10
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is lithium aluminoborate and said radioisotope is holmium-166.
Claim 11
Dependent Claim
20 words
A method as set forth in claim 1 wherein said glass material is magnesium aluminosilicate and said radioisotope is samarium-153.
Claim 12
Dependent Claim
19 words
A method as set forth in claim 1 wherein said glass material is aluminosilicate and said radioisotope is samarium-153.
Claim 13
Dependent Claim
19 words
A method as set forth in claim 1 wherein said glass material is aluminosilicate and said radioisotope is yttrium-90.
Claim 14
Dependent Claim
24 words
A method as set forth in claim 1 wherein said microsphere has a diameter in the range of about 3 to about 30 micrometers.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-08-12 | 1995-02-11 | 1995-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-12 | 1999-02-11 | 1999-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-12 | 2003-02-11 | 2003-08-13 | $7700.00 | Window Closed / Lapsed |