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US5032678A
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Radio labeled high molecular compound comprising unit of asialoglycoprotein acceptor-directing compound and unit of chelate forming compound chemically bonded thereto
Assignee: Nihon Medi Physics Co Ltd
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Filing: 1987-12-30
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Granted: 1991-07-16
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Expires: 2007-12-30
Abstract
Abstract A high molecular compound useful as a non-radioactive carrier, which comprises at least one unit of (1) an asialoglycoprotein acceptor-directing compound and at least one unit of (2) a chelate-forming compound chemically bonded thereto, and which may be labeled with a radioactive metallic element to give a radioactive metallic element-labeled product useful as a radioactive diagnostic or therapeutic agent for liver.
Inventors
- 👤 Komei Washino
- 👤 Miki Kurami
- 👤 Nobuo Ueda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 11:37
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/088; A61K51/0491; A61K51/081; A61K2121/00; A61K2123/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
62 words
A radioactive metallic element-labeled high molecular compound useful as a nuclear medicine, which consists of at least one unit of (1) an asialoglycoprotein acceptor-directing compound selected from the group consisting of asialofetuin, asialocelluloplasmin, asialohaptoglobin, and galactose-bonded polyglucosamine, at least one unit of (2) a chelate-forming compound chemically bonded thereto and (3) at least one radioactive metallic element chelate-bonded to said chelate-forming compound.
Claim 2
Dependent Claim
62 words
A radioactive metallic element-labeled high molecular compound useful as a nuclear medicine, which consists of at least one unit of (1) an asialoglycoprotein acceptor-directing compound selected from the group consisting of asialofetuin, asialocelluloplasmin, asialohaptoglobin, and galactose-bonded polyglucosamine, at least one unit of (2) a chelate-forming compound chemically bonded thereto and (3) at least one radioactive metallic element chelate-bonded to said chelate-forming compound.
Claim 3
Dependent Claim
14 words
The labeled compound according to claim 1, wherein the chelate-forming compound is diethylenetriaminepentaacetic acid.
Claim 4
Dependent Claim
14 words
The labeled compound of claim 2 wherein the radioactive metallic element is 99m Tc.
Claim 5
Dependent Claim
61 words
A process for preparing a radioactive metallic element-labeled compound, which comprises reacting a compound which consists of at least one unit of (1) an asialoglycoprotein acceptor-directing compound selected from the group consisting of asialofetuin, asialocelluloplasmin, asialohaptoglobin, and galactose-bonded polyglucosamine, and at least one unit of (2) a chelate forming compound chemically bonded thereto, with at least one radioactive metallic element (3).
Claim 6
Dependent Claim
61 words
A process for preparing a radioactive metallic element-labeled compound, which comprises reacting a compound which consists of at least one unit of (1) an asialoglycoprotein acceptor-directing compound selected from the group consisting of asialofetuin, asialocelluloplasmin, asialohaptoglobin, and galactose-bonded polyglucosamine, and at least one unit of (2) a chelate forming compound chemically bonded thereto, with at least one radioactive metallic element (3).
Claim 7
Dependent Claim
13 words
The process according to claim 4, wherein the chelate-forming compound is diethylenetriaminepentaacetic acid.
Claim 8
Dependent Claim
14 words
The process according to claim 5 wherein the radioactive metallic element is 99m Tc.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-15 | 1995-01-14 | 1995-07-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-15 | 1999-01-14 | 1999-07-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-15 | 2003-01-14 | 2003-07-16 | $7700.00 | Window Closed / Lapsed |