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Patent US5030653A successfully refreshed from Google Patents.
US5030653A
Expired / Lapsed
US
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Antihyperlipidemic and antiatherosclerotic compounds and compositions
Assignee: Warner Lambert Co LLC
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Filing: 1990-10-23
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Granted: 1991-07-09
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Expires: 2010-10-23
Abstract
Abstract Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.
Inventors
- 👤 Bharat K. Trivedi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 17:12
CPC Classifications
C; C07; C07C; C07C275/00; C07C275/28; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/58; C07D311/78; C07D311/80; C07D311/82; C07D311/90; C07D313/00; C07D313/02; C07D313/06; C07D313/08; C07C2602/00; C07C2602/02; C07C2602/04; C07C2602/08; C07C2602/10; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/06; C07C2603/10; C07C2603/12; C07C2603/18
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
143 words
A compound having the formula ##STR6## wherein R 1 and R 2 are independently selected from alkyl or alkoxy of from one to six carbon atoms; R 3 is hydrogen, alkyl of from one to seven carbon atoms, or phenylmethyl; X is oxygen or sulfur; n is zero, one or two; A is selected from ##STR7## Z is a direct bond, >CH 2 , --CH═CH-- --CH 2 CH 2 --, R 4 is selected from hydrogen alkyl of from one to six carbon atoms, hydroxy, acetoxy, alkoxy of from one to six carbon atoms, phenoxy, fluorine, chlorine, bromine, nitro, trifluoromethyl, carboxyl, --COO-alkyl in which the alkyl portion contains from one to four carbon atoms, amino, alkylamino of from one to six carbon atoms, dialkylamino in which the alkyl groups contain from one to six carbon atoms, --NH-acetyl; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
143 words
A compound having the formula ##STR6## wherein R 1 and R 2 are independently selected from alkyl or alkoxy of from one to six carbon atoms; R 3 is hydrogen, alkyl of from one to seven carbon atoms, or phenylmethyl; X is oxygen or sulfur; n is zero, one or two; A is selected from ##STR7## Z is a direct bond, >CH 2 , --CH═CH-- --CH 2 CH 2 --, R 4 is selected from hydrogen alkyl of from one to six carbon atoms, hydroxy, acetoxy, alkoxy of from one to six carbon atoms, phenoxy, fluorine, chlorine, bromine, nitro, trifluoromethyl, carboxyl, --COO-alkyl in which the alkyl portion contains from one to four carbon atoms, amino, alkylamino of from one to six carbon atoms, dialkylamino in which the alkyl groups contain from one to six carbon atoms, --NH-acetyl; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
12 words
A compound as defined by claim 1 having the same N-[2,6-bis(1-methylethyl)phenyl]-N-40 -(9H-fluoren-9-ylmethyl)urea.
Claim 4
Dependent Claim
28 words
A pharmaceutical composition for treating hyperchlesterolemia or atherosclerosis comprising an ACAT-inhibitory effective amount of a compound as defined by claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
29 words
A method of treating hypercholesterolemia or athersclerosis comprising administering to a mammal in need of such treatment an ACAT-inhibitory effective amount of a compound as defined by claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-08 | 1995-01-07 | 1995-07-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-08 | 1999-01-07 | 1999-07-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-08 | 2003-01-07 | 2003-07-09 | $7700.00 | Window Closed / Lapsed |