Liquid detergents containing anionic surfactant, builder and proteolytic enzyme

Claim 1

A heavy-duty liquid laundry detergent composition comprising, by weight: (a) from about 7% to about 50% of an anionic synthetic surfactant which comprises a C 10 -C 18 alkyl sulfate, a C 10 -C 18 alkyl ethoxy sulfate containing an average of up to about 4 moles of ethylene oxide per mole of alkyl sulfate, a C 11 -C 13 linear alkylbenzene sulfonate, or mixtures thereof; (b) a detergency builder comprising a mixture of from about 5% to about 20% of a saturated fatty acid containing from about 10 to about 14 carbon atoms and from about 1% to about 20% of a water-soluble polycarboxylate builder; (c) from about 0.01% to about 5% of the proteolytic enzyme characterized by the following amino acid sequence: ##STR6## or wherein the Gly at position 166 is replaced with Asn, Ser, Lys, Arg, His, Gln, Ala or Glu; the Gly at position 169 is replaced with Ser; the Met at position 222 is replaced with Gln, Phe, Cys, His, Asn, Glu, Ala or Thr; the Gly at position 166 is replaced with Lys and the Met at position 222 is replaced with Cys; or the Gly at position 169 is replaced with Ala and the Met at position 222 is replaced with Ala; (d) from about 0.01 to about 50 millimoles of calcium ion per liter of composition; and (e) from about 10% to about 80% of water; said composition containing at least about 20% of (a)+(b) and having an initial pH of from about 6.5 to about 9.5 at a concentration of 0.2% in water at 20° C.