US5028432A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical capsules containing panetidine
Assignee: GlaxoSmithKline Inc
•
Filing: 1990-02-22
•
Granted: 1991-07-02
•
Expires: 2010-02-22
Abstract
Abstract The invention relates to a pharmaceutical composition in the form of a gelatin capsules consisting of a filling containing as active ingredient ranitidine or a physiologically acceptable salt thereof surrounded by a gelatin shell. The filling is formulated based on a non-aqueous matrix consisting of at least one fatty acid glyceride and/or mineral oil or paraffin. Preferably the matrix contains at least one surfactant. The matrix is essentially hydrophobic in character but is also sufficiently hydrophilic to permit dispersion and dissolution of the capsule filling in the gastrointenstinal tract.
Inventors
- 👤 Sham K. Chopra
- 👤 Tribhovan T. Makadia
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/34; A61K31/341; A61K9/00; A61K9/48; A61K9/4841; A61K9/4858; A61P; A61P43/00
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
50 words
A pharmaceutical composition in the form of gelatin capsules comprising a filling containing as active ingredient ranitidine or a physiologically acceptable salt thereof surrounded by a gelatin shell, said filling being based on a non-aqueous matrix consisting essentially of at least one fatty acid glyceride and/or mineral oil or paraffin.
Claim 2
Dependent Claim
50 words
A pharmaceutical composition in the form of gelatin capsules comprising a filling containing as active ingredient ranitidine or a physiologically acceptable salt thereof surrounded by a gelatin shell, said filling being based on a non-aqueous matrix consisting essentially of at least one fatty acid glyceride and/or mineral oil or paraffin.
Claim 3
Dependent Claim
16 words
A pharmaceutical composition according to claim 1 in which said matrix contains at least one surfactant.
Claim 4
Dependent Claim
37 words
A pharmaceutical composition according to claim 2 in which said matrix consisting essentially of a mixture of fatty acid glycerides and/or mineral oils or paraffins in which at least one component of the mixture possesses surfactant properties.
Claim 5
Dependent Claim
13 words
A pharmaceutical composition according to claim 2 in which said surfactant is lecithin.
Claim 6
Dependent Claim
17 words
A pharmaceutical composition according to claim 1 in which said gelatin shell is a soft gelatin shell.
Claim 7
Dependent Claim
28 words
A pharmaceutical composition according to claim 1 in which said filling contains 30 to 70% (w/w) ranitidine in the form of either free base or physiologically acceptable salt.
Claim 8
Dependent Claim
15 words
A pharmaceutical composition according to claim 1 containing ranitidine in the form of ranitidine hydrochloride.
Claim 9
Dependent Claim
70 words
A pharmaceutical composition in the form of gelatin capsules consisting essentially of a filling containing as active ingredient ranitidine or a physiologically acceptable salt thereof surrounded by a gelatin shell, said filling being based on a non-aqueous matrix comprising a first oily excipient which is a mixture of glycerides of medium chain fatty acids and a second oily excipient which is a mixture of glycerides of long chain fatty acids.
Claim 10
Dependent Claim
70 words
A pharmaceutical composition in the form of gelatin capsules consisting essentially of a filling containing as active ingredient ranitidine or a physiologically acceptable salt thereof surrounded by a gelatin shell, said filling being based on a non-aqueous matrix comprising a first oily excipient which is a mixture of glycerides of medium chain fatty acids and a second oily excipient which is a mixture of glycerides of long chain fatty acids.
Claim 11
Dependent Claim
45 words
A pharmaceutical composition according to claim 8 in which said first oily excipient is a mixture of triglycerides of C 8 -C 10 fatty acids and said second oily excipient is a mixture of mono-, di-, and/or triglycerides of C 12 -C 18 fatty acids.
Claim 12
Dependent Claim
34 words
A pharmaceutical composition according to claim 9 in which said first oily excipient comprises 20% to 60% (w/w) of said filling and said second oily excipient comprises 5 to 35% (w/w) of said filling.
Claim 13
Dependent Claim
17 words
A pharmaceutical composition according to claim 8 in which said gelatin shell is a soft gelatin shell.
Claim 14
Dependent Claim
28 words
A pharmaceutical composition according to claim 8 in which said filling contains 30 to 70% (w/w) ranitidine in the form of either free base or physiologically acceptable salt.
Claim 15
Dependent Claim
15 words
A pharmaceutical composition according to claim 8 containing ranitidine in the form of ranitidine hydrochloride.
Claim 16
Dependent Claim
94 words
A pharmaceutical composition according to claim 8 containing ranitidine hydrochloride as active ingredient in which said ranitidine hydrochloride comprises 45% to 55% (w/w) of said filling and said filling is based on a non-aqueous matrix consisting essentially of a first oily excipient which is a mixture of triglycerides of C 8 -C 10 fatty acids and comprises 30% to 40% (w/w) of said filling, and a second oily excipient which is a mixture of mono-, di- and/or triglycerides of C 12 -C 18 fatty acids and comprises 10% to 25% (w/w) of said filling.
Claim 17
Dependent Claim
37 words
A composition suitable for use as a filling for gelatin capsules comprising ranitidine or a physiologically acceptable salt thereof and a non-aqueous matrix consisting essentially of at least one fatty acid glyceride and/or mineral oil or paraffin.
Claim 18
Dependent Claim
37 words
A composition suitable for use as a filling for gelatin capsules comprising ranitidine or a physiologically acceptable salt thereof and a non-aqueous matrix consisting essentially of at least one fatty acid glyceride and/or mineral oil or paraffin.
Claim 19
Dependent Claim
37 words
A non-aqueous pharmaceutical composition comprising ranitidine or a physiologically acceptable salt thereof and a non-aqueous matrix consisting essentially of at least one fatty acid glyceride and/or mineral oil or paraffin together with a pharmaceutically acceptable non-aqueous vehicle.
Claim 20
Dependent Claim
37 words
A non-aqueous pharmaceutical composition comprising ranitidine or a physiologically acceptable salt thereof and a non-aqueous matrix consisting essentially of at least one fatty acid glyceride and/or mineral oil or paraffin together with a pharmaceutically acceptable non-aqueous vehicle.
References Cited (Backward Citations)
US4128658A
Cited
DE2753526A1
Cited
US4521431A
Cited
JPS58174308A
Cited
US4610990A
Cited
GB2218333A
Cited
GB2222772A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-01 | 1994-12-31 | 1995-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-01 | 1998-12-31 | 1999-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-01 | 2002-12-31 | 2003-07-02 | $7700.00 | Window Closed / Lapsed |