US4521431A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aminoalkyl furan derivative
Assignee: Glaxo Group Ltd
•
Filing: 1982-08-09
•
Granted: 1985-06-04
•
Expires: 2002-08-09
Abstract
Abstract A novel crystal form of ranitidine (N-[2-[[[5-(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl-N'-methyl-2-nitro-1,1-ethenediamine) hydrochloride, designated Form 2, and having favorable filtration and drying characteristics, is characterized by its infra-red spectrum and/or by its x-ray powder diffraction patterns.
Inventors
- 👤 Derek L. Crookes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:00
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/34; C; C07; C07D; C07D307/00; C07D307/02; C07D307/34; C07D307/38; C07D307/52; A61P; A61P1/00; A61P1/04; A61P43/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
52 words
Form 2 ranitidine hydrochloride characterised by an infra-red spectrum as a mull in mineral oil showing the following main peaks: ______________________________________
3260 1075
3190 1045
3100 1021
2560 1006
2510 991
2470 972
1620 958
1590 810
1570 800
1263 760
1230 700
1220 660
1195 640
1163 620 cm.sup.-1
1130
______________________________________
Claim 2
Dependent Claim
52 words
Form 2 ranitidine hydrochloride characterised by an infra-red spectrum as a mull in mineral oil showing the following main peaks: ______________________________________
3260 1075
3190 1045
3100 1021
2560 1006
2510 991
2470 972
1620 958
1590 810
1570 800
1263 760
1230 700
1220 660
1195 640
1163 620 cm.sup.-1
1130
______________________________________
Claim 3
Dependent Claim
150 words
Form 2 ranitidine hydrochloride according to claim 1 further characterised by the following x-ray powder diffraction pattern expressed in terms of "d" spacings and relative intensities (1) (s=strong, m=medium, w=weak, v=very, d=diffuse) and obtained by the Debye Scherrer method in a 114.6 mm diameter camera by exposure for 12 hours to CoK a radiation and for 3 hours to CuKa radiation: ______________________________________
d (Å) I d (Å) I
______________________________________
10.73 m 3.40 2 w
6.50 3 vwd 3.35 2 vwd
6.13 m 3.25 wd
5.83 s 3.12 2 vw
5.63 3 vwd 3.04 2 vwd
5.42 s 2.97 3 vwd
5.06 2 vw 2.93 3 vwd
4.92 w 2.88 3 vwd
4.59 2 vw 2.81 vwd
4.40 s 2.72 vwd
4.28 w 2.66 3 vwd
3.91 wd 2.47 2 vwd
3.79 s 2.44 vw
3.71 m 2.34 2 vwd
3.60 vwd 2.30 3 vwd
3.46 m 2.21 2 vwd
______________________________________
Claim 4
Dependent Claim
29 words
A pharmaceutical composition in the form of tablets comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharamceutically acceptable carrier or diluent.
Claim 5
Dependent Claim
29 words
A pharmaceutical composition in the form of tablets comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 6
Dependent Claim
29 words
A pharmaceutical composition in the form of capsules comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 7
Dependent Claim
29 words
A pharmaceutical composition in the form of capsules comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 8
Dependent Claim
30 words
A pharmaceutical composition in the form of a powder comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 9
Dependent Claim
30 words
A pharmaceutical composition in the form of a powder comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 10
Dependent Claim
29 words
A pharamaceutical composition in the form of lozenges comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 11
Dependent Claim
29 words
A pharmaceutical composition in the form of lozenges comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 12
Dependent Claim
29 words
A pharmaceutical composition in the form of suppositories comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 13
Dependent Claim
29 words
A pharmaceutical composition in the form of suppositories comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 14
Dependent Claim
30 words
A pharmaceutical composition in the form of retention enemas comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 15
Dependent Claim
30 words
A pharmaceutical composition in the form of retention enemas comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 16
Dependent Claim
30 words
A pharmaceutical composition in the form of an ointment comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 17
Dependent Claim
30 words
A pharmaceutical composition in the form of an ointment comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 18
Dependent Claim
32 words
A method of treating condition mediated through histamine H 2 -receptors which comprises administering to a patient an effective amount of a compound as claimed in claim 1 to relieve said condition.
Claim 19
Dependent Claim
32 words
A method of treating condition mediated through histamine H 2 -receptors which comprises administering to a patient an effective amount of a compound as claimed in claim 2 to relieve said condition.
References Cited (Backward Citations)
US4128658A
Cited
US4279819A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-03 | 1988-12-03 | 1989-06-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-03 | 1992-12-03 | 1993-06-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-03 | 1996-12-03 | 1997-06-04 | $7700.00 | Window Closed / Lapsed |