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US4521431A Expired / Lapsed US ⏱️ 0.0 years remaining

Aminoalkyl furan derivative

Assignee: Glaxo Group Ltd
•
Filing: 1982-08-09
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Granted: 1985-06-04
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Expires: 2002-08-09
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Abstract

Abstract A novel crystal form of ranitidine (N-[2-[[[5-(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl-N'-methyl-2-nitro-1,1-ethenediamine) hydrochloride, designated Form 2, and having favorable filtration and drying characteristics, is characterized by its infra-red spectrum and/or by its x-ray powder diffraction patterns.

Inventors

  • 👤 Derek L. Crookes

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-24 20:25
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/34; C; C07; C07D; C07D307/00; C07D307/02; C07D307/34; C07D307/38; C07D307/52; A61P; A61P1/00; A61P1/04; A61P43/00

Claims Analysis

Total Claims: 19
Claim 1
Independent Claim 52 words
Form 2 ranitidine hydrochloride characterised by an infra-red spectrum as a mull in mineral oil showing the following main peaks: ______________________________________ 3260 1075 3190 1045 3100 1021 2560 1006 2510 991 2470 972 1620 958 1590 810 1570 800 1263 760 1230 700 1220 660 1195 640 1163 620 cm.sup.-1 1130 ______________________________________
Claim 2
Dependent Claim 52 words
Form 2 ranitidine hydrochloride characterised by an infra-red spectrum as a mull in mineral oil showing the following main peaks: ______________________________________ 3260 1075 3190 1045 3100 1021 2560 1006 2510 991 2470 972 1620 958 1590 810 1570 800 1263 760 1230 700 1220 660 1195 640 1163 620 cm.sup.-1 1130 ______________________________________
Claim 3
Dependent Claim 150 words
Form 2 ranitidine hydrochloride according to claim 1 further characterised by the following x-ray powder diffraction pattern expressed in terms of "d" spacings and relative intensities (1) (s=strong, m=medium, w=weak, v=very, d=diffuse) and obtained by the Debye Scherrer method in a 114.6 mm diameter camera by exposure for 12 hours to CoK a radiation and for 3 hours to CuKa radiation: ______________________________________ d (Å) I d (Å) I ______________________________________ 10.73 m 3.40 2 w 6.50 3 vwd 3.35 2 vwd 6.13 m 3.25 wd 5.83 s 3.12 2 vw 5.63 3 vwd 3.04 2 vwd 5.42 s 2.97 3 vwd 5.06 2 vw 2.93 3 vwd 4.92 w 2.88 3 vwd 4.59 2 vw 2.81 vwd 4.40 s 2.72 vwd 4.28 w 2.66 3 vwd 3.91 wd 2.47 2 vwd 3.79 s 2.44 vw 3.71 m 2.34 2 vwd 3.60 vwd 2.30 3 vwd 3.46 m 2.21 2 vwd ______________________________________
Claim 4
Dependent Claim 29 words
A pharmaceutical composition in the form of tablets comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharamceutically acceptable carrier or diluent.
Claim 5
Dependent Claim 29 words
A pharmaceutical composition in the form of tablets comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 6
Dependent Claim 29 words
A pharmaceutical composition in the form of capsules comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 7
Dependent Claim 29 words
A pharmaceutical composition in the form of capsules comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 8
Dependent Claim 30 words
A pharmaceutical composition in the form of a powder comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 9
Dependent Claim 30 words
A pharmaceutical composition in the form of a powder comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 10
Dependent Claim 29 words
A pharamaceutical composition in the form of lozenges comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 11
Dependent Claim 29 words
A pharmaceutical composition in the form of lozenges comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 12
Dependent Claim 29 words
A pharmaceutical composition in the form of suppositories comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 13
Dependent Claim 29 words
A pharmaceutical composition in the form of suppositories comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 14
Dependent Claim 30 words
A pharmaceutical composition in the form of retention enemas comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 15
Dependent Claim 30 words
A pharmaceutical composition in the form of retention enemas comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 16
Dependent Claim 30 words
A pharmaceutical composition in the form of an ointment comprising Form 2 ranitidine hydrochloride as defined in claim 1 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 17
Dependent Claim 30 words
A pharmaceutical composition in the form of an ointment comprising Form 2 ranitidine hydrochloride as defined in claim 2 together with at least one inert pharmaceutically acceptable carrier or diluent.
Claim 18
Dependent Claim 32 words
A method of treating condition mediated through histamine H 2 -receptors which comprises administering to a patient an effective amount of a compound as claimed in claim 1 to relieve said condition.
Claim 19
Dependent Claim 32 words
A method of treating condition mediated through histamine H 2 -receptors which comprises administering to a patient an effective amount of a compound as claimed in claim 2 to relieve said condition.

References Cited (Backward Citations)

US4128658A Cited
US4279819A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1988-06-03 1988-12-03 1989-06-04 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1992-06-03 1992-12-03 1993-06-04 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1996-06-03 1996-12-03 1997-06-04 $7700.00 Window Closed / Lapsed

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