US5026537A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for imaging atherosclerotic plaque
Assignee: Janssen Biotech Inc
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Filing: 1989-04-06
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Granted: 1991-06-25
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Expires: 2009-04-06
Abstract
Abstract This invention pertains to a method of imaging atherosclerotic plaque using radiolabeled monoclonal antibodies that are specific for activated platelets or activated endothelial cells. The method is capable of determining the site of endothelial injury. This method involves the administration of a platelet-specific labeled monoclonal antibody or antibody fragment to a patient. The antibody is allowed to accumulate at the plaque site and the plaque is then scanned with a photoscanner. The detected signals are then converted into an image of the plaque.
Inventors
- 👤 Peter E. Daddona
- 👤 Harvey J. Berger
- 👤 Rodger P. McEver
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 14:23
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1018; A61K2123/00; Y; Y10; Y10S; Y10S424/00; Y10S424/809; Y10S530/00; Y10S530/866
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
82 words
A method of imaging an atherosclerotic plaque, comprising the steps of: a. administering to an individual suspected of having an atherosclerotic plaque, an effective amount of a radiolabeled monoclonal antibody or fragment thereof, specific for activated platelet or endothelial cell membrane protein GMP-140; b. allowing the radiolabeled monoclonal antibody or antibody-fragment to accumulate at the plaque site; c. detecting the signal generated by the radiolabel by means of a photoscanning device; d. converting the detected signal into an image of the plaque.
Claim 2
Independent Claim
82 words
A method of imaging an atherosclerotic plaque, comprising the steps of: a. administering to an individual suspected of having an atherosclerotic plaque, an effective amount of a radiolabeled monoclonal antibody or fragment thereof, specific for activated platelet or endothelial cell membrane protein GMP-140; b. allowing the radiolabeled monoclonal antibody or antibody-fragment to accumulate at the plaque site; c. detecting the signal generated by the radiolabel by means of a photoscanning device; d. converting the detected signal into an image of the plaque.
Claim 3
Dependent Claim
26 words
A method of claim 1, wherein the monoclonal antibody fragment is selected from the group consisting of Fab, Fab', F(ab') 2 , and F v fragments.
Claim 4
Dependent Claim
24 words
A method of claim 1, wherein the monoclonal antibody is labeled with a radioactive material selected from the group consisting of Technetium-99m and Indium-111.
Claim 5
Dependent Claim
11 words
A method of claim 1, wherein the monoclonal antibody is S12.
Claim 6
Dependent Claim
13 words
A method of claim 1, wherein the atherosclerotic plaque is ulcerated or ruptured.
Claim 7
Independent Claim
67 words
A method of imaging an atherosclerotic plaque. comprising the steps of: administering to an individual suspected of having atherosclerotic plaque, an effective amount of a 99m Tc-labeled Fab fragment of monoclonal antibody S12; b. allowing the radiolabeled antibody fragment to accumulate at the plaque site; c. detecting the signal generated by means of a gamma camera; d. converting the detected signal into an image of the plaque.
Claim 8
Independent Claim
67 words
A method of imaging an atherosclerotic plaque. comprising the steps of: administering to an individual suspected of having atherosclerotic plaque, an effective amount of a 99m Tc-labeled Fab fragment of monoclonal antibody S12; b. allowing the radiolabeled antibody fragment to accumulate at the plaque site; c. detecting the signal generated by means of a gamma camera; d. converting the detected signal into an image of the plaque.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-06-24 | 1994-12-24 | 1995-06-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-06-24 | 1998-12-24 | 1999-06-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-06-24 | 2002-12-24 | 2003-06-25 | $7700.00 | Window Closed / Lapsed |