Water-dispersible polymeric compositions

Claim 2

A polymeric composition comprising (A) about 42.5 to about 98 weight % of at least one water insoluble polymer, (B) about 0.5 to about 30 weight % of at least one oil-in-water emulsifier which is polymeric, water soluble or water dispersible and nonionic. (C) about 1 to about 27.5 weight % of at least one water-in-oil emulsifier which is water insoluble; anionic or amphoteric; more hydrophobic than said oil-in-water emulsifier; substantially dispersible in a low molecular weight, more volatile than water, and substantially water immiscible organic solvent; and compatible with said oil-in-water emulsifier, said polymeric composition being in the form of particles having an average particle size of about 0.1-0.8 μm.

Claim 3

The composition of claim 1 wherein said water insoluble polymer is a pH-dependent acidic enteric cellulose polymer, a neutral cellulose ester, a pH-dependent basic cellulosic polymer, a pH-dependent polyvinylpyridine derivative, a pH-dependent polystyrene derivative, a pH-dependent styrene/vinylpyridine copolymer, a maleic anhydride copolymer, an acrylic/acrylate copolymer, an acrylic ester, a lactic/glycolic acid copolymer, a polyester or a polypeptide.

Claim 4

The composition of claim 1 wherein said oil-in-water emulsifier has a HLB value of greater than or equal to about 10.

Claim 5

The composition of claim 1 wherein said oil-in-water emulsifier is a poloxamer, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan monostearate, or a mixture thereof; said water-in-oil emulsifier is a phosphated monoglyceride, a phosphated diglyceride, a citric acid ester of a monoglyceride, a sodium stearoyl lactylate, a calcium stearoyl lactylate, glycerol monooleate, a diacetylated tartaric acid ester of a monoglyceride, a sulfonated ester, alpha-tocopherol hemisuccinate, a soy phosphatide, a phospholipid, a lysophospholipid, or a mixture thereof; and wherein said water insoluble polymer is cellulose acetate phthalate, cellulose acetate trimellitate, cellulose acetate succinate, cellulose acetate propionate phthalate, hydroxypropyl methyl cellulose phthalate, cellulose acetate butyrate, cellulose acetate propionate, ethyl cellulose, cellulose propionate morpholinobutyrate, cellulose acetate diethylaminohydroxypropyl ether, diethylaminomethyl cellulose, 1-piperidyl-ethyl-hydroxyethylcellulose, benzylamino-ethylhydroxy-ethylcellulose, cellulose acetate, diethylaminoacetate, poly(2-vinylpyridine), poly(4-vinylpyridine), poly(2-vinyl-5-ethylpyridine), copoly(2-vinylpyridine/styrene), copoly(2-methyl-5-vinylpyridine/styrene) imidazoline modified copoly(styrene-acrylonitrile), dimethylaminoethyl modified polystyrene, poly(methyl vinyl ether/maleic anhydride), poly(ethylene maleic anhydride), poly(styrene/maleic anhydride), a ethylacrylate/methyl methacrylate copolymer, poly(ethylene terephthalate) or a mixture thereof.

Claim 6

The composition of claim 3 wherein said oil-in-water emulsifier is a block copolymer of the formula: ##STR2## wherein x and y are positive integers and said copolymer has about 50 to 80 weight % polyethylene and has an average molecular weight of greater than 3,000, or a polyalkylene glycol ether of the formula: C.sub.4 H.sub.9 O--(CH.sub.2 --CH--CH.sub.3 --O).sub.x --(CH.sub.2 --CH.sub.2 --O).sub.y --CH.sub.2 --CH.sub.2 --OH wherein x and y are positive integers and said glycol ether has a molecular weight of about 3,500; and said water-in-oil emulsifier is lecithin or a mixture of phosphated mono- and di-glycerides.

Claim 7

A product of a process comprising: (I) contacting (A) an organic solvent system comprising: (a) at least one water insoluble polymer, and (b) at least one low molecular weight, more volatile than water, and substantially water-immiscible organic solvent, with (B) a combination of surfactants comprising: (i) at least one oil-in-water emulsifier which is polymeric, water soluble or water dispersible, and nonionic, and (ii) at least one water-in-oil emulsifier which is water insoluble, anionic or amphoteric, more hydrophobic than said oil-in-water emulsifier, substantially dispersible in said organic solvent system, and compatible with said oil-in-water emulsifier, to result in an organic phase, (II) emulsifying said organic phase by adding sufficient water to said organic phase while subjecting the resulting mixture to comminuting force to form a water-in-polymer solution emulsion; and adding to said water-in-polymer solution emulsion an additional amount of water effective to result in a phase inversion to form a polymer solution-in-water emulsion, (III) passing the polymer solution-in-water emulsion through a microfluidizer such that the water insoluble polymer is in the form of droplets having an average size in range of about 0.1 to 0.8 μm, (IV) removing the organic solvent from the polymer-in-water solution emulsion to form an aqueous colloidal dispersion of polymer, and (V) drying the aqueous colloidal dispersion of polymer to form a water-dispersible powder, wherein, Component (A) comprises about 5 to about 35 weight % of Component (A)(a) and about 95 to about 65 weight % of Component (A)(b), based on the total weight of (A)(a) plus (A)(b); and Component (B)(i) is present in an amount of about 0.5% to about 70% of the weight of Component (A)(a), and Component (B)(ii) is present in an amount of about 1% to about 65% of the weight of Component (A)(a).

Claim 8

A product of a process comprising: (I) contacting (A) an organic solvent system comprising: (a) at least one water insoluble polymer, and (b) at least one low molecular weight, more volatile than water, and substantially water-immiscible organic solvent, with (B) a combination of surfactants comprising: (i) at least one oil-in-water emulsifier which is polymeric, water soluble or water dispersible, and nonionic, and (ii) at least one water-in-oil emulsifier which is water insoluble, anionic or amphoteric, more hydrophobic than said oil-in-water emulsifier, substantially dispersible in said organic solvent system, and compatible with said oil-in-water emulsifier, to result in an organic phase, (II) emulsifying said organic phase by adding sufficient water to said organic phase while subjecting the resulting mixture to comminuting force to form a water-in-polymer solution emulsion; and adding to said water-in-polymer solution emulsion an additional amount of water effective to result in a phase inversion to form a polymer solution-in-water emulsion, (III) passing the polymer solution-in-water emulsion through a microfluidizer such that the water insoluble polymer is in the form of droplets having an average size in range of about 0.1 to 0.8 μm, (IV) removing the organic solvent from the polymer-in-water solution emulsion to form an aqueous colloidal dispersion of polymer, and (V) drying the aqueous colloidal dispersion of polymer to form a water-dispersible powder, wherein, Component (A) comprises about 5 to about 35 weight % of Component (A)(a) and about 95 to about 65 weight % of Component (A)(b), based on the total weight of (A)(a) plus (A)(b); and Component (B)(i) is present in an amount of about 0.5% to about 70% of the weight of Component (A)(a), and Component (B)(ii) is present in an amount of about 1% to about 65% of the weight of Component (A)(a).

Claim 9

The product of claim 6 wherein for said process Component (A) comprises about 10 to about 30 weight % of Component (A)(a) and about 90 to about 70 weight % of Component (A)(b), based on the total weight of (A)(a) plus (A)(b); and Component (B)(i) is present in an amount of about 10% to about 50% of the weight of Component (A)(a), and Component (B)(ii) is present in an amount of about 2% to about 40% of the weight of Component (A)(a); said organic solvent is methylene chloride, ethylene dichloride, chloroform, or isopropanol plus ethyl acetate; said water insoluble polymer is cellulose acetate phthalate, cellulose acetate trimellitate, cellulose acetate succinate, cellulose acetate propionate phthalate, hydroxypropyl methyl cellulose phthalate, cellulose acetate, cellulose acetate butyrate, cellulose acetate propionate, ethyl cellulose, cellulose propionate morpholinobutyrate, cellulose acetate diethylaminohydroxypropyl ether, diethylaminomethyl cellulose, 1-piperidyl-ethyl-hydroxyethylcellulose, benzylaminoethylhydroxy-ethylcellulose, acetate diethylaminoacetate, cellulose poly(2-vinylpyridine), poly(4-vinylpyridine), poly(2-vinyl-5-ethylpyridine), copoly(2-vinylpyridine/styrene), copoly(2-methyl-5-vinylpyridine/styrene) imidazoline modified copoly(styrene-acrylonitrile), dimethylaminoethyl modified polystyrene, poly(methyl vinyl ether/maleic anhydride), poly(ethylene/maleic anhydride), poly(styrene/maleic anhydride), a ethylacrylate/methyl methacrylate copolymer, poly(ethylene terephthalate) or a mixture thereof; said oil-in-water emulsifier is a poloxamer, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan monostearate, or a mixture thereof; said water-in-oil emulsifier is a phosphated monoglyceride, a phosphated diglyceride, a citric acid ester of a monoglyceride, a sodium stearoyl lactylate, a calcium stearoyl lactylate, glycerol monooleate, a diacetylated tartaric acid ester of a monoglyceride, a sulfonated ester, alpha-tocopherol hemisuccinate, a soy phosphatide, a phospholipid, a lysophospholipid, or a mixture thereof; and the powder is in the form of particles having an average size of about 15 to 30 μm.

Claim 10

A product of a process comprising: (I) contacting (A) an organic solvent system comprising: (a) at least one water insoluble polymer, and (b) at least one low molecular weight, more volatile than water, and substantially water-immiscible organic solvent, with (B) at least one water-in-oil emulsifier which is water insoluble, anionic or amphoteric, and substantially dispersible in said organic solvent system, to result in an organic phase, and (II) emulsifying said organic phase by adding sufficient water to said organic phase while subjecting the resulting mixture to a comminnuting force to form a water-in-polymer solution emulsion; and adding to said water-in-polymer solution emulsion an additional amount of water effective to result in a phase conversion to form a polymer solution-in-water emulsion, wherein, said water contains at least one oil-in-water emulsifier which is polymeric, water soluble or water dispersible, nonionic, less hydrophobic than said water-in-oil emulsifier, and compatible with said water-in-oil emulsifier, (III) passing the polymer solution-in-water emulsion through a particle size reduction means such that the water insoluble polymer is in the form of droplets having an average size in the range of about 0.1 to 0.8 μm, (IV) removing the organic solvent from the polymer solution-in-water emulsion to form an aqueous colloidal dispersion of polymer, and (V) drying the aqueous colloidal dispersion of polymer to form a water-dispersible powder, wherein, Component (A) comprises about 5 to about 35 weight % of Component (A)(a) and about 95 to about 65 weight % of Component (A)(b), based on the total weight of (A)(a) plus (A)(b); and said oil-in-water emulsifier is present in an amount of about 0.5% to about 70% of the weight of Component (A)(a), and said water-in-oil emulsifier is present in an amount of about 1% to about 65% of the weight of Component (A)(a).

Claim 11

A product of a process comprising: (I) contacting (A) an organic solvent system comprising: (a) at least one water insoluble polymer, and (b) at least one low molecular weight, more volatile than water, and substantially water-immiscible organic solvent, with (B) at least one water-in-oil emulsifier which is water insoluble, anionic or amphoteric, and substantially dispersible in said organic solvent system, to result in an organic phase, and (II) emulsifying said organic phase by adding sufficient water to said organic phase while subjecting the resulting mixture to a comminnuting force to form a water-in-polymer solution emulsion; and adding to said water-in-polymer solution emulsion an additional amount of water effective to result in a phase conversion to form a polymer solution-in-water emulsion, wherein, said water contains at least one oil-in-water emulsifier which is polymeric, water soluble or water dispersible, nonionic, less hydrophobic than said water-in-oil emulsifier, and compatible with said water-in-oil emulsifier, (III) passing the polymer solution-in-water emulsion through a particle size reduction means such that the water insoluble polymer is in the form of droplets having an average size in the range of about 0.1 to 0.8 μm, (IV) removing the organic solvent from the polymer solution-in-water emulsion to form an aqueous colloidal dispersion of polymer, and (V) drying the aqueous colloidal dispersion of polymer to form a water-dispersible powder, wherein, Component (A) comprises about 5 to about 35 weight % of Component (A)(a) and about 95 to about 65 weight % of Component (A)(b), based on the total weight of (A)(a) plus (A)(b); and said oil-in-water emulsifier is present in an amount of about 0.5% to about 70% of the weight of Component (A)(a), and said water-in-oil emulsifier is present in an amount of about 1% to about 65% of the weight of Component (A)(a).

Claim 12

The product of claim 8 wherein for said process Component (A) comprises about 10 to about 30 weight % of Component (A)(a) and about 90 to about 70 weight % of Component (A)(b), based on the total weight of (A)(a) plus (A)(b); and said oil-in-water emulsifier is present in an amount of about 10% to about 50% of the weight of Component (A)(a), and said water-in-oil emulsifier is present in an amount of about 2% to about 40% of the weight of Component (A)(a); said organic solvent is methylene chloride, ethylene dichloride, chloroform, or isopropanol plus ethyl acetate; said water insoluble polymer is cellulose acetate phthalate, cellulose acetate trimellitate, cellulose acetate succinate, cellulose acetate propionate phthalate, hydroxypropyl methyl cellulose phthalate, cellulose acetate, cellulose acetate butyrate, cellulose acetate propionate, ethyl cellulose, cellulose propionate morpholinobutyrate, cellulose acetate diethylaminohydroxypropyl ether, diethylaminomethyl cellulose, 1-piperidyl-ethyl-hydroxyethylcellulose, benzylamino-ethyl-hydroxy-ethylcellulose, cellulose acetate, diethylaminoacetate, poly(2-vinylpyridine), poly(4-vinylpyridine), poly(2-vinyl-5-ethylpyridine), copoly(2-vinylpyridine/styrene), copoly(2-methyl-5-vinylpyridine/styrene) imidazoline modified copoly(styrene-acrylonitrile), dimethylaminoethyl modified polystyrene, poly(methyl vinyl ether/maleic anhydride), poly(ethylene/maleic anhydride), poly(styrene/maleic anhydride), a ethylacrylate/methyl methacrylate copolymer, poly(ethylene terephthalate) or a mixture thereof; said oil-in-water emulsifier is a poloxamer, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan monostearate, or a mixture thereof; said water-in-oil emulsifier is a phosphated monoglyceride, a phosphated diglyceride, a citric acid ester of a monoglyceride, a sodium stearoyl lactylate, a calcium stearoyl lactylate, glycerol monooleate, a diacetylated tartaric acid ester of a monoglyceride, a sulfonated ester, alpha-tocopherol hemisuccinate, a soy phosphatide, a phospholipid, a lysophosopholipid, or a mixture thereof; and the powder is in the form of particles having an average size of about 15-30 μm.

Claim 13

A process for preparing a solid dosage form comprising: (A) dispersing the polymeric composition of claim 1 in an aqueous solution which comprises at least about 85 weight % water to prepare a coating dope, and (B) coating a solid medicament core with the coating dope of step (A).

Claim 14

The process of claim 10 wherein said aqueous solution further comprises up to about 40 weight % of at least one coating additive.

Claim 15

The process of claim 11 wherein said coating additive is a plasticizer selected from the group consisting of dimethyl phthalate, diethyl phthalate, triacetin, and a mixture thereof.

Claim 16

The process of claim 11 wherein said coating additive is a surfactant.

Claim 17

The process of claim 11 wherein said coating additive is dimethyl phthalate, triacetin, diethyl phthalate, dioctyl phthalate, or a monoglyceride.

Claim 18

The process of claim 10 wherein said coating is carried out by spraying said cores with said coating dope in a pan coater.

Claim 19

A process for preparing a solid dosage form comprising: (A) dispersing the polymeric composition of claim 2 in an aqueous solution which comprises at least about 85 weight % water to prepare a coating dope, and (B) coating a solid medicament core with the coating dope of step (A).

Claim 20

A process for preparing a solid dosage form comprising: (A) dispersing the polymeric composition of claim 3 in an aqueous solution which comprises at least about 85 weight % water to prepare a coating dope, and (B) coating a solid medicament core with the coating dope of step (A).

Claim 21

A process for preparing a solid dosage form comprising: (A) dispersing the polymeric composition of claim 4 in an aqueous solution which comprises at least about 85 weight % water to prepare a coating dope, and (B) coating a solid medicament core with the coating dope of step (A).

Claim 22

A process for preparing a solid dosage form comprising: (A) dispersing the polymeric composition of claim 5 in an aqueous solution which comprises at least about 85 weight % water to prepare a coating dope, and (B) coating a solid medicament core with the coating dope of step (A).

Claim 23

A process for preparing a solid dosage form comprising: (A) dispersing the polymeric composition of claim 6 in an aqueous solution which comprises at least about 85 weight % water to prepare a coating dope, and (B) coating a solid medicament core with the coating dope of step (A).

Claim 24

A process for preparing a solid dosage form comprising: (A) dispersing the polymeric composition of claim 7 in an aqueous solution which comprises at least about 85 weight % water to prepare a coating dope, and (B) coating a solid medicament core with the coating dope of step (A).

Claim 25

A process for preparing a solid dosage form comprising: (A) dispersing the polymeric composition of claim 8 in an aqueous solution which comprises at least about 85 weight % water to prepare a coating dope, and (B) coating a solid medicament core with the coating dope of step (A).

Claim 26

A process for preparing a solid dosage form comprising: (A) dispersing the polymeric composition of claim 9 in an aqueous solution which comprises at least about 85 weight % water to prepare a coating dope, and (B) coating a solid medicament core with the coating dope of step (A).

Claim 27

A solid dosage form comprises an effective amount of a medicament coated with the polymeric composition of claim 1.

Claim 28

The solid dosage form of claim 24 wherein said medicament is present in an amount of about 96 to about 75 weight %; and said polymeric composition is present in an amount of about 4 to about 25 weight %.

Claim 29

A solid dosage form comprising an effective amount of a medicament coated with the polymeric composition of claim 2.

Claim 30

A solid dosage form comprising an effective amount of a medicament coated with the polymeric composition of claim 3.

Claim 31

A solid dosage form comprising an effective amount of a medicament coated with the polymeric composition of claim 4.

Claim 32

A solid dosage form comprising an effective amount of a medicament coated with the polymeric composition of claim 5.

Claim 33

A solid dosage form comprising an effective amount of a medicament coated with the polymeric composition of claim 6.

Claim 34

A solid dosage form comprising an effective amount of a medicament coated with the polymeric composition of claim 7.

Claim 35

A solid dosage form comprising an effective amount of a medicament coated with the polymeric composition of claim 8.

Claim 36

A solid dosage form comprising an effective amount of a medicament coated with the polymeric composition of claim 9.

Claim 37

The solid dosage form of claim 24 wherein said medicament is aspirin, ibuprofen, erythromycin, theophylline, propanolol, endomethacin sucrose or a mixture thereof.

Claim 38

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 24, wherein the effective amount of medicament is an amount to render said treatment.

Claim 39

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 25, wherein the effective amount of medicament is an amount to render said treatment.

Claim 40

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 26, wherein the effective amount of medicament is an amount to render said treatment.

Claim 41

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 27, wherein the effective amount of medicament is an amount to render said treatment.

Claim 42

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 28, wherein the effective amount of medicament is an amount to render said treatment.

Claim 43

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 29, wherein the effective amount of medicament is an amount to render said treatment.

Claim 44

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 30, wherein the effective amount of medicament is an amount to render said treatment.

Claim 45

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 31, wherein the effective amount of medicament is an amount to render said treatment.

Claim 46

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 32, wherein the effective amount of medicament is an amount to render said treatment.

Claim 47

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 33, wherein the effective amount of medicament is an amount to render said treatment.

Claim 48

A method for treating animals in need of treatment comprising orally administering to said animals the solid dosage form of claim 34, wherein the effective amount of medicament is an amount to render said treatment.