Patent US5023262A successfully refreshed from Google Patents.
US5023262A
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Hydrogenated rapamycin derivatives
Assignee: Wyeth LLC
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Filing: 1990-08-14
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Granted: 1991-06-11
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Expires: 2010-08-14
Abstract
Abstract A derivative of rapamycin where one, two, or three of the double bonds at the 1-,3-, or 5-positions of rapamycin have been reduced to the corresponding alkane, or a pharmaceutically acceptable salt thereof, which by virtue of its antifungal activity is useful in treating fungal infections. ##STR1##
Inventors
- 👤 Craig E. Caufield
- 👤 John H. Musser
- 👤 James M. Rinker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 11:34
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/12; C07D498/18; A; A61; A61P; A61P31/00; A61P31/04; A61P31/10; C07H; C07H19/00; C07H19/01
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
34 words
A derivative of rapamycin where one, two, or three of the double bonds at the 1-, 3-, or 5-positions of rapamycin have been reduced to the corresponding alkane or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
34 words
A derivative of rapamycin where one, two, or three of the double bonds at the 1-, 3-, or 5-positions of rapamycin have been reduced to the corresponding alkane or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
14 words
A compound of claim 1 which is 1,2-dihydrorapamycin or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
14 words
A compound of claim 1 which is 1,2,3,4-tetrahydrorapamycin or a pharmaceutically acceptable salt thereof.
Claim 5
Independent Claim
49 words
A method of treating fungal infections by administering an effective amount of a compound which is a derivative of rapamycin in which one, two, or three of the double bonds at the 1-, 3-, or 5-positions have been reduced to the corresponding alkane or a pharmaceutically acceptable salt thereof.
Claim 6
Independent Claim
49 words
A method of treating fungal infections by administering an effective amount of a compound which is a derivative of rapamycin in which one, two, or three of the double bonds at the 1-, 3-, or 5-positions have been reduced to the corresponding alkane or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
20 words
A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
11 words
A composition as claimed in claim 5, in unit dosage form.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-06-10 | 1994-12-10 | 1995-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-06-10 | 1998-12-10 | 1999-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-06-10 | 2002-12-10 | 2003-06-11 | $7700.00 | Window Closed / Lapsed |