Patent US5021452A successfully refreshed from Google Patents.
US5021452A
Expired / Lapsed
US
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Process for enhancing wound healing
Assignee: University of Washington
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Filing: 1990-03-28
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Granted: 1991-06-04
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Expires: 2010-03-28
Abstract
Abstract There is disclosed a process for improving wound healing, comprising administering ascorbate or derivatives thereof to a wound site at a concentration of at least 20 μmol/L and irradiating the wound site with a low-power laser at a wave length of about 600 nm to about 1100 nm. The process for improving wound healing can be used for the healing of deep, interior wounds with longer wave length radiation and higher energy output radiation. The process can further be used for improving the healing of superficial skin wounds with shorter wave lengths and lower energy output of the low-power laser.
Inventors
- 👤 Robert F. Labbe
- 👤 Rebecca L. Rettmer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 10:31
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/06; A61N5/0613; A61N5/0616; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/365; A61K31/375; A61N5/067; A61N2005/0658; A61N2005/0659
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
68 words
A process for enhancing cellular uptake of ascorbate, ascorbic acid or dehydroascorbic acid at a wound site of a mammal, comprising administering to the wound site ascorbate, ascorbic acid or dehydroascorbic acid at an extracellular concentration measured at the wound site of at least 20μmol/L and also irradiating the wound site with a low-power laser at a wave length of from about 600 nm to about 1100 nm.
Claim 2
Dependent Claim
68 words
A process for enhancing cellular uptake of ascorbate, ascorbic acid or dehydroascorbic acid at a wound site of a mammal, comprising administering to the wound site ascorbate, ascorbic acid or dehydroascorbic acid at an extracellular concentration measured at the wound site of at least 20μmol/L and also irradiating the wound site with a low-power laser at a wave length of from about 600 nm to about 1100 nm.
Claim 3
Dependent Claim
35 words
The process of claim 1, further comprising administering a therapeutically effective amount of a nutrient or nutrients to the wound site, wherein the nutrient or nutrients do not contain ascorbate, ascorbic acid or dehydroascorbic acid.
Claim 4
Dependent Claim
92 words
A process for enhancing cellular uptake of ascorbate, ascorbic acid or dehydroascorbic acid at an interior wound site of a mammal comprising internally administering ascorbate, ascorbic acid or dehydroascorbic acid to increase the concentration of circulating ascorbate, ascorbic acid or dehydroascorbic acid to an extracellular concentration at the wound site of at least 20μmol/L and also externally irradiating the wound site with a low-power laser at a wave length of from about 600 nm to about 1100 nm and energy delivery from about 1.0 mJoules/cm 2 to about 1000 mJoules/cm 2 .
Claim 5
Dependent Claim
92 words
A process for enhancing cellular uptake of ascorbate, ascorbic acid or dehydroascorbic acid at an interior wound site of a mammal comprising internally administering ascorbate, ascorbic acid or dehydroascorbic acid to increase the concentration of circulating ascorbate, ascorbic acid or dehydroascorbic acid to an extracellular concentration at the wound site of at least 20μmol/L and also externally irradiating the wound site with a low-power laser at a wave length of from about 600 nm to about 1100 nm and energy delivery from about 1.0 mJoules/cm 2 to about 1000 mJoules/cm 2 .
Claim 6
Dependent Claim
35 words
The process of claim 3, further comprising administering a therapeutically effective amount of a nutrient or nutrients to the wound site, wherein the nutrient or nutrients do not contain ascorbate, ascorbic acid or dehydroascorbic acid.
Claim 7
Dependent Claim
32 words
The process of claim 3 wherein the extracellular concentration of ascorbate, ascorbic acid or dehydroascorbic acid at the wound site after oral or systemic administration is from about 20μmol/L to about 142μmol/L.
Claim 8
Dependent Claim
85 words
A process for enhancing cellular uptake of ascorbate, ascorbic acid or dehydroascorbic acid at a surface wound site of a mammal, comprising administering directly to the wound site ascorbate, ascorbic acid or dehydroascorbic acid to increase the extracellular concentration measured at the wound site to at least 20μmol/L and also irradiating the wound site with a low-power laser at a wave length from about 600 nm to about 1100 nm and an energy delivery from about 1.0 mJoules/cm 2 to about 1000 mJoules/cm 2 .
Claim 9
Dependent Claim
85 words
A process for enhancing cellular uptake of ascorbate, ascorbic acid or dehydroascorbic acid at a surface wound site of a mammal, comprising administering directly to the wound site ascorbate, ascorbic acid or dehydroascorbic acid to increase the extracellular concentration measured at the wound site to at least 20μmol/L and also irradiating the wound site with a low-power laser at a wave length from about 600 nm to about 1100 nm and an energy delivery from about 1.0 mJoules/cm 2 to about 1000 mJoules/cm 2 .
Claim 10
Dependent Claim
35 words
The process of claim 6, further comprising administering a therapeutically effective amount of a nutrient or nutrients to the wound site, wherein the nutrient or nutrients do not contain ascorbate, ascorbic acid or dehydroascorbic acid.
Claim 11
Dependent Claim
21 words
The process of claim 7 wherein the nutrient is an amino acid, a trace element, a vitamin, or a combination thereof.
Claim 12
Dependent Claim
27 words
The process of claim 7 wherein the nutrient or nutrients are selected from the group consisting of proline, lysine, protein hydrolysate, zinc, calcium, pyridoxin and combinations thereof.
Claim 13
Dependent Claim
12 words
The process of claim 41 wherein the nutrient is proline or lysine.
Claim 14
Dependent Claim
39 words
The process of claim 10 wherein the extracellular proline concentration measured at the wound site is from about 90μmol/L to about 300μmol/L and the extracellular lysine concentration measured at the wound site is from about 100μmol/L to about 250μmol/L.
Claim 15
Dependent Claim
18 words
The process of claim 6 wherein the laser has an energy output in either pulsed or continuous mode.
Claim 16
Dependent Claim
38 words
The process of claim 6 wherein the extracellular concentration of ascorbate, ascorbic acid or dehydroascorbic acid at the wound site after direct injection or topical application to the wound site is from about 100μmol/L to about 5000 μmol/L.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-06-03 | 1994-12-03 | 1995-06-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-06-03 | 1998-12-03 | 1999-06-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-06-03 | 2002-12-03 | 2003-06-04 | $7700.00 | Window Closed / Lapsed |