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US5021422A
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Method and composition for treating hyperproliferative skin diseases using 6-aminopurine cytokinins
Assignee: Senetek PLC
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Filing: 1989-06-08
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Granted: 1991-06-04
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Expires: 2009-06-08
Abstract
Abstract It has been discovered that 6-(substituted amino)purine cytokinins, such as kinetin, induce differentiation, and consequently reduce or eliminate the abnormally high rate of proliferation, of hyperproliferating cells associated with hyperproliferative skin diseases, such as psoriasis. Thus, the present invention provides methods and compositions for treating hyperproliferative skin diseases in mammals, particularly such diseases associated with hyperproliferating epidermal cells in humans, by administering to the hyperproliferating cells associated with such a disease, in the skin of a mammal suffering therefrom, a differentiation-inducing effective amount of a 6-(substituted amino)purine cytokinin.
Inventors
- 👤 Lars Bolund
- 👤 Peter K. A. Jensen
- 👤 Peter Bjerring
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K31/519; A61K31/52; A61P; A61P17/00; A61P43/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
36 words
A method of treating psoriasis in a human suffering therefrom which method comprises administering to the hyperproliferating cells, associated with said disease, of the skin of said human a differentiation-inducing-effective amount of a 6-(substituted amino)purine cytokinin.
Claim 2
Independent Claim
36 words
A method of treating psoriasis in a human suffering therefrom which method comprises administering to the hyperproliferating cells, associated with said disease, of the skin of said human a differentiation-inducing-effective amount of a 6-(substituted amino)purine cytokinin.
Claim 3
Dependent Claim
41 words
A method according to claim 1, wherein the 6-(substituted amino)purine cytokinin is of formula I: ##STR3## wherein R 1 is selected from the group consisting of furfuryl, phenyl, benzyl, n-alkyl of 4, 5 or 6 carbon atoms, (cyclohexyl)methyl, (3-hydroxymethyl-3-methyl)allyl, and 3,3-dimethylallyl.
Claim 4
Independent Claim
12 words
A method according to claim 2wherein the 6-(substituted amino)purine cytokinin is kinetin.
References Cited (Backward Citations)
EP0103878A2
Cited
JPS6019709A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-06-03 | 1994-12-03 | 1995-06-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-06-03 | 1998-12-03 | 1999-06-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-06-03 | 2002-12-03 | 2003-06-04 | $7700.00 | Window Closed / Lapsed |