US5019350A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fluorescent polymers
Assignee: Pfizer Inc
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Filing: 1986-02-13
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Granted: 1991-05-28
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Expires: 2006-02-13
Abstract
Abstract A sensor for the determination of the concentration of a dissolved substance in an aqueous medium comprising an optical fiber having on the distal end thereof an adherent, water-insoluble organic polymer having a plurality of fluorescent organic substituents, which may be the same or different, covalently bonded to said polymer through ester or amide linkages.
Inventors
- 👤 David Rhum
- 👤 Richard S. Matthews
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 11:15
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/84; C; C09; C09K; C09K11/00; C09K11/06; G01N33/53; G01N33/531; G01N33/532; G01N33/533
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
161 words
A sensor for the determination of the concentration of a dissolved substance in an aqueous medium comprising an optical fiber having a distal end to which is stably bonded an adherent, water-insoluble, stable, rapid response fluorescent polymeric indicator comprising an organic polymeric portion to which is covalently bonded, through ester or amide linkages, a plurality of fluorescent organic substituents, which may be the same or different, said polymeric portion being derived from an organic polymer having functionality consisting of hydroxyl or amine groups depending from the polymer chain and said fluorescent organic substituents being derived from fluorescent indicator molecules having, in addition to the desired fluorescent and indicating properties, linking functionality suitable for forming ester or amide linkages with said polymer functionality, said linking functionality being located sufficiently remote from the fluorescent portion of the indicator molecules so that it does not adversely affect the fluorescent indicating capability of the indicator molecule when the said amide or ester linkages are formed.
Claim 2
Dependent Claim
161 words
A sensor for the determination of the concentration of a dissolved substance in an aqueous medium comprising an optical fiber having a distal end to which is stably bonded an adherent, water-insoluble, stable, rapid response fluorescent polymeric indicator comprising an organic polymeric portion to which is covalently bonded, through ester or amide linkages, a plurality of fluorescent organic substituents, which may be the same or different, said polymeric portion being derived from an organic polymer having functionality consisting of hydroxyl or amine groups depending from the polymer chain and said fluorescent organic substituents being derived from fluorescent indicator molecules having, in addition to the desired fluorescent and indicating properties, linking functionality suitable for forming ester or amide linkages with said polymer functionality, said linking functionality being located sufficiently remote from the fluorescent portion of the indicator molecules so that it does not adversely affect the fluorescent indicating capability of the indicator molecule when the said amide or ester linkages are formed.
Claim 3
Dependent Claim
28 words
A sensor according to claim 1, wherein said polymer contains pendant hydroxyl groups, a proportion of said groups being esterified with one or more fluorescent organic carboxylic acids.
Claim 4
Dependent Claim
14 words
A sensor according to claim 2, wherein said polymer is a hydroxyethyl methacrylate polymer.
Claim 5
Dependent Claim
15 words
A sensor according to claim 3 wherein said polymer is a copolymer with methyl methacrylate.
Claim 6
Dependent Claim
12 words
A sensor according to claim 2, wherein said polymer is poly(vinyl alcohol).
Claim 7
Dependent Claim
14 words
An oxygen sensor according to claim 2 wherein said fluorescent acid is 4-(1-pyrene)-butanoic acid.
Claim 8
Dependent Claim
13 words
A pH-sensor according to claim 2 wherein said fluorescent acid is 4-umbelliferonylacetic acid.
Claim 9
Dependent Claim
36 words
A sensor according to claim 7 adapted for carbon dioxide analysis wherein said fluorescent polymer is in contact with a bicarbonate electrolyte enveloped by a carbon-dioxide-permeable, water-impervious membrane mounted on the distal end of said fiber.
Claim 10
Dependent Claim
14 words
A sensor according to claim 8, wherein said membrane is composed of silicone rubber.
Claim 11
Dependent Claim
29 words
A combination pH and pO 2 sensor according to claim 2, wherein said pendant hydroxyl groups are esterified in part with 4-umbelliferonylacetic acid and in part with 4-(1-pyrene)butanoic acid.
Claim 12
Dependent Claim
26 words
A sensor according to claim 2, wherein said polymer is bonded to said fiber distal end with a curing agent reactive with said pendant hydroxyl groups.
Claim 13
Dependent Claim
20 words
A sensor according to claim 10, wherein said curing agent is polyacrylic acid, glutaraldehyde, tetraethyl orthosilicate, gamma-glycidoxypropyltrimethoxysilane or boric acid.
Claim 14
Dependent Claim
146 words
A stable, rapid response fluorescent polymeric indicator for the determination of the concentration of a dissolved substance in an aqueous medium, said indicator comprising an organic polymeric portion to which is covalently bonded, through ester or amide linkages, a plurality of fluorescent organic substituents, which may be the same or different, said polymeric portion being derived from an organic polymer having functionality consisting of hydroxyl or amine groups, depending from the polymer chain and said fluorescent organic substituents being derived from fluorescent indicator molecules having, in addition to the desired fluorescent and indicating properties, linking functionality suitable for forming ester or amide linkages with said polymer functionality, said linking functionality being located sufficiently remote from the fluorescent portion of the indicator molecule so that it does not adversely affect the fluorescent indicating capability of the indicator molecule when the said amide or ester linkages are formed.
Claim 15
Dependent Claim
146 words
A stable, rapid response fluorescent polymeric indicator for the determination of the concentration of a dissolved substance in an aqueous medium, said indicator comprising an organic polymeric portion to which is covalently bonded, through ester or amide linkages, a plurality of fluorescent organic substituents, which may be the same or different, said polymeric portion being derived from an organic polymer having functionality consisting of hydroxyl or amine groups, depending from the polymer chain and said fluorescent organic substituents being derived from fluorescent indicator molecules having, in addition to the desired fluorescent and indicating properties, linking functionality suitable for forming ester or amide linkages with said polymer functionality, said linking functionality being located sufficiently remote from the fluorescent portion of the indicator molecule so that it does not adversely affect the fluorescent indicating capability of the indicator molecule when the said amide or ester linkages are formed.
Claim 16
Dependent Claim
28 words
An indicator according to claim 13, wherein said polymer contains pendant hydroxyl groups, a proportion of said groups being esterified with one or more fluorescent organic carboxylic acids.
Claim 17
Dependent Claim
12 words
An indicator according to claim 14, wherein said polymer is poly(vinyl alcohol).
Claim 18
Dependent Claim
14 words
An indicator according to claim 14, wherein said polymer is a hydroxyethyl methacrylate polymer.
Claim 19
Dependent Claim
15 words
An indicator according to claim 16, wherein said polymer is a copolymer with methyl methacrylate.
Claim 20
Dependent Claim
14 words
An oxygen indicator according to claim 14, wherein said carboxylic acid is 4-(1-pyrene)-butanoic acid.
Claim 21
Dependent Claim
14 words
A pH indicator according to claim 14, wherein said carboxylic acid is 4-umbelliferonylacetic acid.
Claim 22
Dependent Claim
22 words
A combination pH and pO 2 indicator according to claim 14, wherein said carboxylic acids, are, respectively, 4-umbelliferonylacetic acid and 4-(1-pyrene)-butanoic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-27 | 1994-11-26 | 1995-05-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-27 | 1998-11-26 | 1999-05-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-27 | 2002-11-26 | 2003-05-28 | $7700.00 | Window Closed / Lapsed |