US5017229A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Water insoluble derivatives of hyaluronic acid
Assignee: Genzyme Corp
•
Filing: 1990-06-25
•
Granted: 1991-05-21
•
Expires: 2010-06-25
Abstract
Abstract A water insoluble, biocompatible gel that includes the reaction product of hyaluronic acid, a polyanionic polysaccharide, and an activating agent.
Inventors
- 👤 James W. Burns
- 👤 Steven Cox
- 👤 Alan E. Walts
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:20
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K47/00; A61K47/30; A61K47/36; A61L; A61L31/00; A61L31/04; A61L31/041; A61L31/042; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0072; C08L; C08L5/00; C08L5/08
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
43 words
A method for making a water insoluble biocompatible gel, said method comprising combining an aqueous solution of HA at a concentration in the range between 0.4% and 2.6% w/w, a polyanionic polysaccharide, and an activating agent under conditions sufficient to form said gel.
Claim 2
Independent Claim
43 words
A method for making a water insoluble biocompatible gel, said method comprising combining an aqueous solution of HA at a concentration in the range between 0.4% and 2.6% w/w, a polyanionic polysaccharide, and an activating agent under conditions sufficient to form said gel.
Claim 3
Dependent Claim
25 words
The method of claim 1 wherein said polyanionic polysaccharide is chosen from the group consisting of carboxymethylcellulose, carboxymethylamylose, chondroitin-6-sulfate, dermatin sulfate, heparin, and heparin sulfate.
Claim 4
Dependent Claim
11 words
The method of claim 2 wherein said polyanionic polysaccharide is carboxymethylcellulose.
Claim 5
Dependent Claim
11 words
The method of claim 2 wherein said polyanionic polysaccharide is carboxymethylamylose.
Claim 6
Dependent Claim
22 words
The method of claim 1 wherein said HA and said polyanionic polysaccharide are added together, followed by addition of said activating agent.
Claim 7
Dependent Claim
20 words
The method of claim 1 wherein said polyanionic polysaccharide is combined with said activating agent, followed by addition of HA.
Claim 8
Dependent Claim
21 words
The method of claim 1 wherein said HA is combined with said activating agent, followed by addition of said polyanionic polysaccharide.
Claim 9
Dependent Claim
12 words
The method of claim 1 wherein said activating agent comprises a carbodiimide.
Claim 10
Dependent Claim
15 words
The method of claim 8 wherein said carbodiimide comprises 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide, or 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide methiodide.
Claim 11
Dependent Claim
15 words
The method of claim 1 wherein polyanionic polysaccharide is present in a concentration of 0.005-0.1M.
Claim 12
Dependent Claim
16 words
The method of claim 10 wherein said polyanionic polysaccharide is present in a concentration of 0.01-0.02M.
Claim 13
Dependent Claim
18 words
The method of claim 1 wherein said method is carried out at a pH of 4.0 to 5.0.
Claim 14
Dependent Claim
21 words
The method of claim 1 wherein the molar ratio of said polyanionic polysaccharide to said activating agent is at least 1:1.
Claim 15
Dependent Claim
20 words
The method of claim 13 wherein the molar ratio of said polyanionic polysaccharide to said activating agent is about 1:4.
Claim 16
Dependent Claim
13 words
A water insoluble biocompatible gel prepared according to the method of claim 1.
Claim 17
Dependent Claim
18 words
A water insoluble, biocompatible gel comprising the reaction product of HA, a polyanionic polysaccharide, and an activating agent.
Claim 18
Dependent Claim
18 words
A water insoluble, biocompatible gel comprising the reaction product of HA, a polyanionic polysaccharide, and an activating agent.
Claim 19
Dependent Claim
12 words
The gel of claim 16 wherein said activating agent comprises a carbodiimide.
Claim 20
Dependent Claim
15 words
The gel of claim 17 wherein said carbodiimide comprises 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide, or 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide methiodide.
Claim 21
Dependent Claim
15 words
The gel of claim 16, further comprising a pharmaceutically active substance dipsersed within said gel.
Claim 22
Dependent Claim
27 words
The gel of claim 19 wherein said pharmaceutically active substance is chosen from the group consisting of growth factors, enzymes, drugs, biopolymers, and biologically compatible synthetic polymers.
Claim 23
Dependent Claim
25 words
The gel of claim 16 wherein said polyanionic polysaccharide is chosen from the group consisting of carboxymethylcellulose, carboxymethylamylose, chondroitin-6-sulfate, dermatin sulfate, heparin, and heparin sulfate.
Claim 24
Dependent Claim
11 words
The gel of claim 21 wherein said polyanionic polysaccharide is carboxymethylcellulose.
Claim 25
Dependent Claim
11 words
The gel of claim 21 wherein said polyanionic polysaccharide is carboxymethylamylose.
Claim 26
Dependent Claim
17 words
The gel of claim 16 wherein said gel is in the form of an adhesion prevention composition.
Claim 27
Dependent Claim
15 words
The gel of claim 24 wherein said composition is in the form of a membrane.
References Cited (Backward Citations)
GB2151244A
Cited
WO1986000079A1
Cited
WO1986000912A1
Cited
US4582865A
Cited
EP0193510B1
Cited
US4774093A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-20 | 1994-11-19 | 1995-05-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-20 | 1998-11-19 | 1999-05-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-20 | 2002-11-19 | 2003-05-21 | $7700.00 | Window Closed / Lapsed |