EP0193510B1
Expired / Lapsed
EP
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Shaped article of hyaluronic acid and processes for its preparation
Assignee: Seagull Merger Corp
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Filing: 1986-02-25
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Granted: 1988-11-23
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Expires: 2006-02-25
Abstract
Abstract A shaped article based upon cross-linked, possibly derivatized hyaluronic acid or a salt thereof is characterized in that it has a dry matter content of at least 65 percent by weight and a tensile strength of at least 2 N/cm<sup>2</sup>. The shaped article may be prepared by pressure-drying or freeze-drying a corresponding hyaluronic acid gel.
Inventors
- 👤 Tomas Mälson
- 👤 Leif Ahrgren
- 👤 Anthony Norman De Belder
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 19:40
CPC Classifications
C; C08; C08L; C08L5/00; C08L5/08; A; A61; A61L; A61L27/00; A61L27/14; A61L27/20; A61L27/50; A61L27/58; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0072
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
46 words
A shaped article based upon cross-linked, possibly derivatized hyaluronic acid or a salt thereof, characterized in that it in a substantially unswollen state has a dry matter content of at least 65 percent by weight and a tensile strength of at least 2 N/cm 2 .
Claim 2
Dependent Claim
46 words
A shaped article based upon cross-linked, possibly derivatized hyaluronic acid or a salt thereof, characterized in that it in a substantially unswollen state has a dry matter content of at least 65 percent by weight and a tensile strength of at least 2 N/cm 2 .
Claim 3
Dependent Claim
18 words
The article according to claim 1, characterized in that the dry matter content is 85-98 percent by weight.
Claim 4
Dependent Claim
28 words
The article according to claim 1 or 2, characterized in that the tensile strength is greater than 50 N/cm 2 , preferably greater than 100 N/cm 2 .
Claim 5
Dependent Claim
17 words
The article according to any one of claims 1-3, characterized in that it is plate- or sheet-shaped.
Claim 6
Dependent Claim
33 words
A process of preparing a shaped article according to any one of claims 1-4, characterized by compressing a gel of cross-linked, possibly derivatized hyaluronic acid or a salt thereof between two pressure surfaces.
Claim 7
Dependent Claim
33 words
The process according to claim 5, characterized in that at least one pressure surface has a sufficient porosity to permit passage of the fluid squeezed out from the gel through the pressure surface.
Claim 8
Dependent Claim
25 words
The process according to claim 5 or 6, characterized in that the compression is effected with a pressure of 10-10 5 kPa, preferably 200-1000 kPa.
Claim 9
Dependent Claim
35 words
A process of preparing a shaped article according to any one of claims 1-4, characterized by subjecting a gel of a cross-linked, possibly derivatized hyaluronic acid or a salt thereof to a vacuum permitting freeze-drying.
Claim 10
Dependent Claim
30 words
The process according to claim 8, characterized in that the gel material is supported on a porous support to be subjected to said vacuum over substantially the entire gel surface.
Claim 11
Dependent Claim
25 words
The process according to claim 8 or 9, characterized in that the dried product obtained is compressed, preferably at a pressure of 10-10 5 kPa.
Claim 12
Dependent Claim
28 words
The process according to any one of claims 5-10, characterized in that the dried product obtained is heat treated at a temperature of about 50 to about 150°C.
References Cited (Backward Citations)
No citation records indexed.
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