Patent US5015478A successfully refreshed from Google Patents.
US5015478A
Expired / Lapsed
US
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Porphycene anti-cancer agents and treatment methods
Assignee: Cytopharm Inc
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Filing: 1989-11-22
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Granted: 1991-05-14
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Expires: 2009-11-22
Abstract
Abstract The therapeutic compositions of this invention comprise one or more porphycene compounds incorporated within liposomes. The method of this invention for treating cancer comprises administering a therapeutically effective amount of a porphycene derivative to a patient, and exposing an affected body area of the patient to a therapeutically sufficient amount of light having a wavelength of from 600 to 950 nm.
Inventors
- 👤 Giulio Jori
- 👤 Matthias Kocher
- 👤 Emanuel Vogel
- 👤 Alexander D. Cross
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:13
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K9/00; A61K9/10; A61K9/127
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
107 words
A method for treating cancer comprising (a) administering a therapeutically effective amount of at least one porphycene compound of Formula I or Formula II to a patient; and (b) exposing the body area of the patient having the cancer to a therapeutically sufficient amount of light having a wavelength of from 600 to 950 nm; ##STR5## wherein R 1 , R 2 , R 3 , and R 4 are hydrogen or a lower alkyl having from 1 to 6 carbons; ##STR6## wherein R 5 , R 6 , R 7 , and R 8 are hydrogen or a lower alkyl having from 1 to 6 carbons.
Claim 2
Independent Claim
107 words
A method for treating cancer comprising (a) administering a therapeutically effective amount of at least one porphycene compound of Formula I or Formula II to a patient; and (b) exposing the body area of the patient having the cancer to a therapeutically sufficient amount of light having a wavelength of from 600 to 950 nm; ##STR5## wherein R 1 , R 2 , R 3 , and R 4 are hydrogen or a lower alkyl having from 1 to 6 carbons; ##STR6## wherein R 5 , R 6 , R 7 , and R 8 are hydrogen or a lower alkyl having from 1 to 6 carbons.
Claim 3
Dependent Claim
21 words
A method according to claim 1 wherein therapeutically sufficient amount of light has a wavelength of from 600 to 950 nm.
Claim 4
Dependent Claim
13 words
A method according to claim 1 including a porphycene compound of Formula I.
Claim 5
Dependent Claim
25 words
A method according to claim 3 including a porphycene compound selected from the group consisting of 2,7,12,17-tetramethylporphycene, 2,7,12,17-tetraethylporphycene, 2,7,12,17-tetra-n-propylporphycene, 2,7,12,17-tetra-n-butylporphycene, 2,7,12,17-tetra-n-pentylporphycene, 2,7,12,17-tetra-n-hexylporphycene, and mixtures thereof.
Claim 6
Dependent Claim
17 words
A method according to claim 1 wherein the porphycene compound is a porphycene compound of Formula II.
Claim 7
Dependent Claim
25 words
A method according to claim 5 including a porphycene compound selected from the group consisting of 9,10,19,20-tetramethylporphycene, 9,10,19,20-tetraethylporphycene, 9,10,19,20-tetra-n-propylporphycene, 9,10,19,20-tetra-n-butylporphycene, 9,10,19,20-tetra-n-pentylporphycene, 9,10,19,20-tetra-n-hexylporphycene, and mixtures thereof.
Claim 8
Dependent Claim
12 words
A method according to claim 1 wherein the porphycene compound is porphycene.
Claim 9
Dependent Claim
15 words
A method according to claim 1 wherein the porphycene is incorporated into a unilamellar liposome.
Claim 10
Dependent Claim
15 words
A method according to claim 1 wherein the porphycene is incorporated into a multilamellar liposome.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-13 | 1994-11-12 | 1995-05-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-13 | 1998-11-12 | 1999-05-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-13 | 2002-11-12 | 2003-05-14 | $7700.00 | Window Closed / Lapsed |