Patent US5015388A successfully refreshed from Google Patents.
US5015388A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Integrated device for the biospecific purification of a liquid containing cellular elements
Assignee: Gambro Industries SAS
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Filing: 1989-03-24
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Granted: 1991-05-14
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Expires: 2009-03-24
Abstract
Abstract A device for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the device comprising a casing, a duct for conducting the liquid into the casing, a filter disposed within the casing for tangentially filtering the liquid to separate first portion from the second portion, a filter disposed within the casing for transversely filtering the separated second portion to biospecifically purify the liquid after the separation of the cellular elements, ducts for evacuating the first portion and second portion from the casing.
Inventors
- 👤 Christian Pusineri
- 👤 Michel Cronenberger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 16:54
CPC Classifications
B; B01; B01D; B01D63/00; B01D63/08; B01D63/087; A; A61; A61M; A61M1/00; A61M1/34; A61M1/3472; A61M1/3475; A61M1/3486; A61M1/3489; B01D61/00; B01D61/14; B01D61/18; A61M1/36; A61M1/3687
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
99 words
A device for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the device comprising: a casing; means for conducting said liquid into said casing; means disposed within said casing for tangentially filtering said liquid to separate said first portion from said second portion; at least one microporous membrane sheet for transversely filtering the second portion, said microporous membrane sheet including purifying molecules grafted thereto to biospecifically purify the liquid after the separation of said cellular elements; and means for evacuating said first portion and second portion from said casing.
Claim 2
Independent Claim
99 words
A device for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the device comprising: a casing; means for conducting said liquid into said casing; means disposed within said casing for tangentially filtering said liquid to separate said first portion from said second portion; at least one microporous membrane sheet for transversely filtering the second portion, said microporous membrane sheet including purifying molecules grafted thereto to biospecifically purify the liquid after the separation of said cellular elements; and means for evacuating said first portion and second portion from said casing.
Claim 3
Dependent Claim
14 words
The device of claim 1, wherein said conducting means comprises at least one duct.
Claim 4
Dependent Claim
15 words
The device of claim 1, wherein said tangential filtration means comprises at least one membrane.
Claim 5
Dependent Claim
19 words
The device of claim 1, wherein said evacuation means includes at least one outlet duct for each filtered portion.
Claim 6
Dependent Claim
32 words
The device according to claim 1, wherein said casing includes an upper plate and a lower plate for enclosing both said tangential filtration means and said at least one microporous membrane sheet.
Claim 7
Dependent Claim
47 words
The device according to claim 5, wherein the casing further comprises an intermediate plate having a first main face and a second main face opposite the first main face, said intermediate plate being disposed between said tangential filtration means and said at least one microporous membrane sheet.
Claim 8
Dependent Claim
25 words
The device according to claim 6, wherein each main face of said intermediate plate includes a network of grooves for circulating said tangentially filtered liquid.
Claim 9
Independent Claim
126 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising: a tubular casing; inlet means for flowing the liquid in an axial direction in the tubular casing; tangential filtration means for separating said first portion of the axially flowing liquid from said second portion, said tangential filtration means including a bundle of hollow fibers; and transverse filtration means disposed in the casing, for conducting the separated second portion in a radial direction in the casing and for biospecifically purifying the second portion of the liquid through flow of said liquid in the radial direction of said casing, said transverse filtration means including a sheet membrane wrapped around said bundle of hollow fibers.
Claim 10
Independent Claim
126 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising: a tubular casing; inlet means for flowing the liquid in an axial direction in the tubular casing; tangential filtration means for separating said first portion of the axially flowing liquid from said second portion, said tangential filtration means including a bundle of hollow fibers; and transverse filtration means disposed in the casing, for conducting the separated second portion in a radial direction in the casing and for biospecifically purifying the second portion of the liquid through flow of said liquid in the radial direction of said casing, said transverse filtration means including a sheet membrane wrapped around said bundle of hollow fibers.
Claim 11
Independent Claim
83 words
A method of biospecifically purifying a liquid containing a portion having cellular elements, the method comprising the steps of: tangentially flowing the liquid over a membrane to separate the portion having cellular elements from the portion without cellular elements; transversely flowing the portion of liquid without cellular elements through at least one microporous membrane sheet having purifying molecules grafted thereto to remove selected biospecific impurities; and recombining the portion of liquid without cellular elements with the portion of the liquid having cellular elements.
Claim 12
Independent Claim
83 words
A method of biospecifically purifying a liquid containing a portion having cellular elements, the method comprising the steps of: tangentially flowing the liquid over a membrane to separate the portion having cellular elements from the portion without cellular elements; transversely flowing the portion of liquid without cellular elements through at least one microporous membrane sheet having purifying molecules grafted thereto to remove selected biospecific impurities; and recombining the portion of liquid without cellular elements with the portion of the liquid having cellular elements.
Claim 13
Independent Claim
105 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising: a casing; means for conducting said liquid into said casing; means disposed within said casing for tangentially filtering said liquid to separate said first portion from said second portion, said tangential filtering means including a bundle of hollow fibers; a sheet membrane wrapped around said bundle of hollow fibers for transversely filtering said separated second portion to biospecifically purify the liquid after the separation of said cellular elements; and means for evacuating said first portion and second portion from said casing.
Claim 14
Independent Claim
105 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising: a casing; means for conducting said liquid into said casing; means disposed within said casing for tangentially filtering said liquid to separate said first portion from said second portion, said tangential filtering means including a bundle of hollow fibers; a sheet membrane wrapped around said bundle of hollow fibers for transversely filtering said separated second portion to biospecifically purify the liquid after the separation of said cellular elements; and means for evacuating said first portion and second portion from said casing.
Claim 15
Independent Claim
103 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising: a casing; means for conducting said liquid into said casing; a bundle of hollow fibers disposed within said casing for tangentially filtering said liquid to separate said first portion from said second portion; a sheet membrane wrapped around itself and disposed within said bundle of hollow fibers, for transversely filtering said separated second portion to biospecifically purify the liquid after the separation of said cellular elements; and means for evacuating said first portion and second portion from said casing.
Claim 16
Independent Claim
103 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising: a casing; means for conducting said liquid into said casing; a bundle of hollow fibers disposed within said casing for tangentially filtering said liquid to separate said first portion from said second portion; a sheet membrane wrapped around itself and disposed within said bundle of hollow fibers, for transversely filtering said separated second portion to biospecifically purify the liquid after the separation of said cellular elements; and means for evacuating said first portion and second portion from said casing.
Claim 17
Independent Claim
116 words
A device for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, said device comprising: a casing; means for conducting said liquid into said casing; means disposed within said casing for tangentially filtering said liquid to separate said first portion from said second portion, said tangential filtering means including an inner bundle of hollow fibers; means disposed within said casing for transversely filtering said separated second portion to biospecifically purify the liquid after the separation of said cellular elements, said transverse filtering means including an annular bundle of hollow fibers surrounding said inner bundle; and means for evacuating said first portion and second portion from said casing.
Claim 18
Independent Claim
116 words
A device for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, said device comprising: a casing; means for conducting said liquid into said casing; means disposed within said casing for tangentially filtering said liquid to separate said first portion from said second portion, said tangential filtering means including an inner bundle of hollow fibers; means disposed within said casing for transversely filtering said separated second portion to biospecifically purify the liquid after the separation of said cellular elements, said transverse filtering means including an annular bundle of hollow fibers surrounding said inner bundle; and means for evacuating said first portion and second portion from said casing.
Claim 19
Independent Claim
117 words
A device for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, said device comprising: a casing; means for conducting said liquid into said casing; means disposed within said casing for transversely filtering the second portion of the liquid to biospecifically purify the liquid after separation of said cellular elements, said transverse filtering means including an inner bundle of hollow fibers; means disposed within said casing for tangentially filtering said liquid to separate said first portion from said second portion, said tangential filtering means including an annular bundle of hollow fibers surrounding said inner bundle; and means for evacuating said first portion and second portion from said casing.
Claim 20
Independent Claim
117 words
A device for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, said device comprising: a casing; means for conducting said liquid into said casing; means disposed within said casing for transversely filtering the second portion of the liquid to biospecifically purify the liquid after separation of said cellular elements, said transverse filtering means including an inner bundle of hollow fibers; means disposed within said casing for tangentially filtering said liquid to separate said first portion from said second portion, said tangential filtering means including an annular bundle of hollow fibers surrounding said inner bundle; and means for evacuating said first portion and second portion from said casing.
Claim 21
Independent Claim
130 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising; a tubular casing; inlet means for flowing the liquid in an axial direction in the tubular casing; tangential filtration means for separating said first portion of the axially flowing liquid from said second portion, said tangential filtration means including a bundle of hollow fibers; and transverse filtration means disposed in the casing, for conducting the separated second portion in a radial direction in the casing and for biospecifically purifying the second portion of the liquid through flow of said liquid in the radial direction of said casing, said transverse filtration means including a sheet membrane wrapped around itself and disposed within said bundle of hollow fibers.
Claim 22
Independent Claim
130 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising; a tubular casing; inlet means for flowing the liquid in an axial direction in the tubular casing; tangential filtration means for separating said first portion of the axially flowing liquid from said second portion, said tangential filtration means including a bundle of hollow fibers; and transverse filtration means disposed in the casing, for conducting the separated second portion in a radial direction in the casing and for biospecifically purifying the second portion of the liquid through flow of said liquid in the radial direction of said casing, said transverse filtration means including a sheet membrane wrapped around itself and disposed within said bundle of hollow fibers.
Claim 23
Independent Claim
127 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising: a tubular casing; inlet means for flowing the liquid in an axial direction in the tubular casing; tangential filtration means for separating said first portion of the axially flowing liquid from said second portion, said tangential filtration means including an inner bundle of hollow fibers; and transverse filtration means disposed in the casing, for conducting the separated second portion in a radial direction in the casing and for biospecifically purifying the second portion of the liquid through flow of said liquid in the radial direction of said casing, said transverse filtration means including an annular bundle of hollow fibers surrounding said inner bundle.
Claim 24
Independent Claim
127 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising: a tubular casing; inlet means for flowing the liquid in an axial direction in the tubular casing; tangential filtration means for separating said first portion of the axially flowing liquid from said second portion, said tangential filtration means including an inner bundle of hollow fibers; and transverse filtration means disposed in the casing, for conducting the separated second portion in a radial direction in the casing and for biospecifically purifying the second portion of the liquid through flow of said liquid in the radial direction of said casing, said transverse filtration means including an annular bundle of hollow fibers surrounding said inner bundle.
Claim 25
Independent Claim
129 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising: a tubular casing; inlet means for flowing the liquid in an axial direction in the tubular casing; transverse filtration means disposed in the casing, for conducting the second portion of the liquid in a radial direction in the casing and for biospecifically purifying the second portion of the liquid through flow of said liquid in the radial direction of said casing, said transverse filtration means including an inner bundle of hollow fibers; and tangential filtration means for separating said first portion of the axially flowing liquid from said second portion, said tangential filtration means including an annular bundle of hollow fibers surrounding said inner bundle.
Claim 26
Independent Claim
129 words
An apparatus for biospecifically purifying a liquid having a first portion containing cellular elements and a second portion without cellular elements, the apparatus comprising: a tubular casing; inlet means for flowing the liquid in an axial direction in the tubular casing; transverse filtration means disposed in the casing, for conducting the second portion of the liquid in a radial direction in the casing and for biospecifically purifying the second portion of the liquid through flow of said liquid in the radial direction of said casing, said transverse filtration means including an inner bundle of hollow fibers; and tangential filtration means for separating said first portion of the axially flowing liquid from said second portion, said tangential filtration means including an annular bundle of hollow fibers surrounding said inner bundle.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-13 | 1994-11-12 | 1995-05-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-13 | 1998-11-12 | 1999-05-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-13 | 2002-11-12 | 2003-05-14 | $7700.00 | Window Closed / Lapsed |