US5013540A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Using NMDA receptor antagonists to reduce damage due to laser treatment
Assignee: The University of Texas System
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Filing: 1989-11-30
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Granted: 1991-05-07
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Expires: 2009-11-30
Abstract
Abstract A method is disclosed for preventing the spread of damage in neuronal tissue that has been selectively burned by surgical laser treatment. Administration of an NMDA receptor blocker, such as dextrorphan, in conjunction with the laser treatment permits the site of the laser burn to be confined more precisely to the desired area, and prevents the spread of damage to surrounding tissue that would normally occur in the days after the laser treatment.
Inventors
- 👤 Dianna A. Redburn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 16:50
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/485
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
42 words
A method of reducing the damaging effects of laser treatment on neuronal tissue, including the step of administering to a living subject an effective amount of a NMDA receptor blocker compound in conjunction with laser treatment of neuronal tissue in that subject.
Claim 2
Independent Claim
42 words
A method of reducing the damaging effects of laser treatment on neuronal tissue, including the step of administering to a living subject an effective amount of a NMDA receptor blocker compound in conjunction with laser treatment of neuronal tissue in that subject.
Claim 3
Dependent Claim
15 words
The method of claim 1, where the NMDA receptor blocker compound is an opioid compound.
Claim 4
Dependent Claim
24 words
The method of claim 1, where the NMDA receptor blocker compound is selected from the group consisting of dextrorphan and pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim
21 words
The method of claim 1, where the NMDA receptor blocker compound is administered to the subject prior to the laser treatment.
Claim 6
Dependent Claim
22 words
The method of claim 1, where the NMDA receptor blocker compound is administered to the subject approximately concurrently with the laser treatment.
Claim 7
Dependent Claim
26 words
The method of claim 1, where the NMDA receptor blocker compound is administered to the subject both prior to and approximately concurrently with the laser treatment.
Claim 8
Independent Claim
42 words
A method of reducing the damaging effects of laser treatment on retinal tissue, including the step of administering to a living subject an effective amount of an NMDA receptor blocker compound in conjunction with laser treatment of retinal tissue in that subject.
Claim 9
Independent Claim
42 words
A method of reducing the damaging effects of laser treatment on retinal tissue, including the step of administering to a living subject an effective amount of an NMDA receptor blocker compound in conjunction with laser treatment of retinal tissue in that subject.
Claim 10
Dependent Claim
15 words
The method of claim 7, where the NMDA receptor blocker compound is an opioid compound.
Claim 11
Dependent Claim
21 words
The method of claim 7, where the NMDA receptor blocker compound is administered to the subject prior to the laser treatment.
Claim 12
Dependent Claim
22 words
The method of claim 7, where the NMDA receptor blocker compound is administered to the subject approximately concurrently with the laser treatment.
Claim 13
Dependent Claim
25 words
The method of claim 7, where the NMDA receptor blocker is administered to the subject both prior to and approximately concurrently with the laser treatment.
Claim 14
Dependent Claim
24 words
The method of claim 7, where the NMDA receptor blocker compound is selected from the group consisting of dextrorphan and pharmaceutically acceptable salts thereof.
References Cited (Backward Citations)
US4806543A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-06 | 1994-11-05 | 1995-05-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-06 | 1998-11-05 | 1999-05-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-06 | 2002-11-05 | 2003-05-07 | $7700.00 | Window Closed / Lapsed |